Antiretroviral use and other risks for HIV-associated neuropathies in an international cohort

Abstract

Exposure to stavudine and didanosine was significantly associated with a heightened risk for symptomatic sensory neuropathy. Reduced vibration thresholds and epidermal nerve fiber densities had the highest diagnostic efficiency of the laboratory indicators of neuropathy examined, but were relatively insensitive in isolation.

Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

“…This ADR was very troublesome for HIV-infected patients. Our results confirm those of several authors on the frequency of neuropathies and risk factors during antiretroviral treatment [31,33,38,39]. This observation indicates that the ADR, however frequent and inconvenient, were supported by patients.…”

“…Antiretroviral therapy in accordance with national guidelines in Mali. Our results confirm those of several authors on the frequency of neuropathies and risk factors during antiretroviral treatment [31][32][33]. In other publications, it is the digestive (gastrointestinal) ADR that predominate, observed in 61.1% of patients in Tunis [34].…”

Hepatitis C seropositivity is not a risk factor for sensory neuropathy among patients with HIV

“…[1][2][3][4] Hepatitis C (HCV) can also be complicated by peripheral neuropathy, with and possibly without cryoglobulinemia. [5][6][7] Since HCV and HIV infection share risk factors and frequently coexist, 8 concerns of possible synergistic effects of these viruses on the peripheral nervous system have been raised.…”

HIV Associated Neuropathies

“…Early epidemiological studies conducted during the pre HAART-era describe an annual incidence of 36% for HIV-SN compared to 21% in the HAART-era [11,13]. The increasing life expectancy of HIV-infected individuals and the high cumulative dosage of neurotoxic antiretroviral substances, in particular ddC, ddl and d4T, represent the causes for the increasing prevalence [14]. Markers of advanced HIV disease such as low CD4 cell count (especially a CD4 nadir below 50 cells/µl), a high HIV viral load (> 10.000 cop./ ml) as well as a diabetes and demographic factors such as age are associated with increased risk of HIV-SN [15,16].…”