Antiretroviral Therapy Initiation and Changes in Self-Reported Depression

Eaton, Ellen; Gravett, Ronnie M; Tamhane, Ashutosh; Mugavero, Michael J.

doi:10.1093/cid/cix217

Cited by 10 publications

(14 citation statements)

References 14 publications

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“…In studies using the same measurements as in our study, the prevalence of depression was 39.3% among newly diagnosed PLWH [47], and the prevalence of anxiety was 64.3% among those who had newly initiated ART [48]. Similar to previous longitudinal studies [24,49], our study showed a signi cant decline in the prevalence of mental health problems at Month 12 compared to pre-treatment. Our study also showed that PLWH who had probable depression when starting ART were more likely to drop out.…”

Section: Discussionsupporting

confidence: 87%

“…The scale contains nine items regarding the frequency of certain negative feelings over the past two weeks (response categories: 0 = never, 1 = sometimes, 2 = often, 3 = almost every day). A score of ≥ 10 was used to de ne probable depression [24,29].…”

Section: Mental Health Problems Measured At Baseline and Month 12mentioning

confidence: 99%

“…A growing body of literature has demonstrated improved mental health status among PLWH after ART initiation. A longitudinal study in the United States showed that, compared to pre-treatment levels, the prevalence of depression decreased from 30-21% after one year on ART [24]. It is possible that the bene ts of ART are mediated via a reduction in in ammatory pathways that affect the risk of depression, such as the kynurenine pathway or tryptophan catabolism [25].…”

mentioning

confidence: 99%

“…ART may also indirectly affect mental health status among PLWH by reducing internalized stigma, increasing community support and access to primary care and psychological support services, and enhancing control of other comorbidities (e.g., tuberculosis and diabetes) [26,27]. Previous studies have identi ed a number of factors that are associated with mental health problems among PLWH on ART, including gender [28], age [22], personal income level [29], marital status [22,28], living arrangements [30], insurance [24], comorbidities [28], sleep quality [23], perceived stigma and discrimination [23,28], and family support [23]. However, most of these studies were cross-sectional and could not identify the predictors of mental health problems after PLWH start taking ART.…”

mentioning

confidence: 99%

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Antiretroviral Therapy–Related Experiences Predict Mental Health Status Among People Living with HIV in China: A Prospective Observational Cohort Study

Xie

Wang

et al. 2020

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Background: Antiretroviral therapy (ART) coverage has increased sharply. This prospective observational cohort study investigated the association between experiences related to ART and mental health problems among a sample of people living with HIV in China.Methods: The participants were 400 people living with HIV who had started ART for the first time in Guangzhou city. They were followed-up one-year after ART initiation. Probable depression and moderate/severe anxiety were measured at baseline and Month 12, while experiences related to ART were measured at Month 6. Univariate and multivariate logistic regressions were used to explore the predictors of mental health status.Results: Among the 300 participants (75.0%) who completed all three surveys, a significant decline in prevalence of probable depression (23.0% at baseline vs. 14.0% at Month 12, P = 0.002) and moderate/severe anxiety (14.7% at baseline vs. 8.7% at Month 12, P = 0.023) was observed during the follow-up period. After adjustment for mental health status and potential confounders at baseline, a number of ART-related experiences at Month 6 were associated with probable depression and/or moderate/severe anxiety measured at Month 12. Improved physical health, relationships with sexual partners, and self-confidence were associated with decreased mental health issues, while the side effects of ART, AIDS-related symptoms, and inconvenience in daily life due to ART use were associated with increased mental health issues.Conclusions: ART-related experiences were predictors of mental health problems, tailored mental health promotion interventions targeting these experiences are needed.

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Section: Discussionsupporting

confidence: 87%

Section: Mental Health Problems Measured At Baseline and Month 12mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Antiretroviral Therapy–Related Experiences Predict Mental Health Status Among People Living with HIV in China: A Prospective Observational Cohort Study

Xie

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…A growing body of literature has demonstrated improved mental health status among PLWH after ART initiation. A longitudinal study in the United States showed that, compared to pre-treatment levels, the prevalence of depression decreased from 30% to 21% after one year on ART [22]. It is possible that the bene ts of ART are mediated via a reduction in in ammatory pathways that affect the risk of depression, such as the kynurenine pathway or tryptophan catabolism [23].…”

Section: Introductionmentioning

confidence: 99%

Associations between antiretroviral therapy–related experiences and mental health status among people living with HIV in China: A prospective observational cohort study

Xie¹,

Wang²,

Li³

et al. 2021

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Background: Mental health problems (e.g., depression and anxiety) are among the most commonly reported comorbidities of HIV. Antiretroviral therapy (ART) coverage has increased sharply. The purposes of this prospective cohort study were to investigate the ART-related experiences and whether they were associated with mental health problems among a sample of people living with HIV undergoing ART in China.Methods: The participants were 400 people living with HIV who had started ART for the first time in Guangzhou city. They were followed-up one-year after ART initiation. Probable depression and moderate/severe anxiety were measured at baseline and Month 12, while experiences related to ART (e.g., side effects and regained self-confidence) were measured at Month 6. Univariate and multivariate logistic regressions were used to explore the associations between baseline characteristics, ART-related experiences and mental health status.Results: Among the 300 participants (75.0%) who completed all three surveys, a significant decline in prevalence of probable depression (23.0% at baseline vs. 14.0% at Month 12, P = 0.002) and moderate/severe anxiety (14.7% at baseline vs. 8.7% at Month 12, P = 0.023) was observed during the follow-up period. After adjustment for mental health status and potential confounders at baseline, a number of ART-related experiences at Month 6 were associated with probable depression and/or moderate/severe anxiety measured at Month 12. Improved physical health, relationships with sexual partners, and self-confidence were associated with decreased mental health issues, while the side effects of ART, AIDS-related symptoms, and inconvenience in daily life due to ART use were associated with increased mental health issues.Conclusions: ART-related experiences were associated with mental health problems, tailored mental health promotion interventions targeting these experiences are needed.

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Depressive Symptoms Before and After Antiretroviral Therapy Initiation Among Older-Aged Individuals in Rural Uganda

et al. 2018

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This study aims to characterize associations between depression symptom severity and HIV infection, both prior to and in years after ART initiation, among older adults. The Ugandan Non-Communicable Diseases & Aging Cohort Study (UGANDAC) is a study of 154 PLWH on ART and 142 community-based, HIV-negative controls. The Hopkins Checklist (HSCL), a 15-item depression scale, was used to screen for depression. We estimate differences in depressive symptoms by HIV and ART status and use multivariable log binomial regression to quantify differences in probable depression between PLWH on ART. HIV-infected and HIV-uninfected participants had a similar age (mean 52.0 vs. 51.9, p = 0.854) and sex distribution (47.4 vs. 47.9% female, p = 0.934). PLWH on ART had lower depression symptom severity than HIV-uninfected controls (mean score: 1.50 vs. 1.60, p = 0.006) and a lower prevalence of probable depression (21.4 vs. 33.8%, p = 0.017). Among 102 PLWH with pre-ART depression screening scores available, their mean depression symptom severity was similar to HIV-uninfected participants (mean 1.56 vs. 1.60, p = 0.512). In adjusted models, PLWH on ART had a lower prevalence of probable depression than HIV-negative controls [adjusted prevalence ratio: 0.68 (95% CI 0.47-0.99)]. In an observational cohort of PLWH over 40 on long-term ART and matched, community-based HIV-uninfected controls in rural Uganda, we found a lower prevalence of self-reported depression among aging PLWH on ART.

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Antiretroviral Therapy Initiation and Changes in Self-Reported Depression

Cited by 10 publications

References 14 publications

Antiretroviral Therapy–Related Experiences Predict Mental Health Status Among People Living with HIV in China: A Prospective Observational Cohort Study

Antiretroviral Therapy–Related Experiences Predict Mental Health Status Among People Living with HIV in China: A Prospective Observational Cohort Study

Associations between antiretroviral therapy–related experiences and mental health status among people living with HIV in China: A prospective observational cohort study

Depressive Symptoms Before and After Antiretroviral Therapy Initiation Among Older-Aged Individuals in Rural Uganda

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