Antiretroviral therapy-induced lipodystrophy

Behera, Vineet; Randive, Makarand; Sundaray, Sambit; Murty, M. S. N.

doi:10.1136/bcr-2014-207090

Cited by 3 publications

(1 citation statement)

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“…ART-induced lipodystrophy which is characterized by peripheral and/or central fat loss or accumulation is described in patients on zidovudine, stavudine, didanosine and most protease inhibitors (19). The management of ART induced lipodystrophy is difficult and complex that includes switching of drug regimen to non lipodystrophic regimen, lifestyle modification, statins, metformin, fibrates, growth hormone and thiazolidinediones (20).…”

Section: Discussionmentioning

confidence: 99%

Antiretroviral therapy associated lipodystrophy; learning from the past

Sereke

Berhe

Bongomin

2021

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BackgroundWith the introduction of effective antiretroviral therapy (ART), descriptions of body shape abnormalities, such as central fat accumulation and peripheral fat loss emerged among persons living with human immunodeficiency virus (HIV). We aimed to determine the prevalence of lipodystrophy and associated risk factors among patients on ART at Orotta National Referral Hospital (ONRH), Asmara, Eritrea.MethodsA single center, retrospective study was conducted at the ONRH, reviewing records of HIV-infected patients commenced on ART between January 2007 and December 2012.ResultsRecords of 250 eligible patients were reviewed. Most were female (59.2%, n=148) with a median age of 35 (IQR-20-63) years. Forty-three (17.2%) participants had body fat abnormalities. 42 (97.6%) had lipoatrophy and 1 (2.4%) buffalo hump. Of the 43 patients with lipodystrophy 34 (79%) were on Stavudine (d4T)/Lamivudine (3TC)/Nevirapine (NVP) regimen, 6 (14%) on Zidovudine (AZT)/3TC/NVP, 2 (4.7%) on d4T/3TC/Efavirenz (EFV) and 1(2.3%) on AZT, 3TC, EFV. EFV-based regimen was significantly associated with lipodystrophy (p< 0.01).ConclusionWe report a high prevalence of lipodystrophy. Four drug regimens were incriminated in the development of lipodystrophy. EFV-based regimen was significantly associated with the lipodystrophy.

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Section: Discussionmentioning

confidence: 99%

Antiretroviral therapy associated lipodystrophy; learning from the past

Sereke

Berhe

Bongomin

2021

Preprint

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Zidovudine/lopinavir/ritonavir

2015

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Isolated collagenoma in an HIV-positive patient on ART: a case report

Wu,

Movassaghi,

DeClerck

et al. 2023

BMC Infect Dis

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Background Collagenomas are rare connective tissue hamartomas composed of dermal collagen. Patients infected with human immunodeficiency virus (HIV) can present with HIV-related lipodystrophy or lipomas. There are no known associations between HIV and collagenomas. Case presentation Here we describe a case of an isolated collagenoma in an HIV patient on ART. The lesion was a seven by four-centimeter subcutaneous nodule with no epidermal changes located on the occipital scalp. This lesion was excised, and histopathology showed thick and randomly arranged collagen bundles, consistent with a collagenoma. Conclusion This case represents an isolated collagenoma presenting in a patient with HIV. It is unclear whether HIV or ART contributed to the development of this collagenoma. Treatment of collagenomas include surgical excision and intralesional corticosteroids. In addition to lipoma or lipodystrophy, it is important to keep collagenoma in the differential diagnosis in a patient presenting with an isolated large indurated subcutaneous nodule.

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Antiretroviral therapy-induced lipodystrophy

Cited by 3 publications

References 3 publications

Antiretroviral therapy associated lipodystrophy; learning from the past

Antiretroviral therapy associated lipodystrophy; learning from the past

Zidovudine/lopinavir/ritonavir

Isolated collagenoma in an HIV-positive patient on ART: a case report

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