Antiretroviral Effects of Nonderivatizcd C<sub>6o</sub><i>In Vitro</i>

Nacsa, János; Segesdi, Judit; Gyuris, Ágnes; Braun, Tibor; Rausch, H.; Buvári-Barcza, Ágnes; Barcza, Lajos; Minárovits, János; Molnár, Joséph

doi:10.1080/15363839708013310

Cited by 13 publications

(11 citation statements)

References 7 publications

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“…Non-derivatized C 60 has been found to inhibit the replication of simian immunodeciency virus (SIV) and the activity of Moloney Murine Leukemia virus (M-MuLV) reverse transcriptase. 77 The 50% inhibitory concentration (EC 50 ) of non-derivatized C 60 was 3 mM, but an explanation of the mechanism has not been reported.…”

Section: Antiviral Activity Of Non-derivatized Fullerenesmentioning

confidence: 99%

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Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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Section: Antiviral Activity Of Non-derivatized Fullerenesmentioning

confidence: 99%

“…Different antiviral effects have been observed depending on the fullerene functionalization. [68][69][70][71][72][73][74][75][76][77] A comparative table with the main results can be found in ref. 78.…”

Section: Fullerenes As Anti-hiv Agentsmentioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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“…In 1997, nonderivatized fullerene (buckminsterfullerene) showed in vitro antiviral activity against another two enveloped positive-sense single-stranded RNA viruses similar to SARS-CoV-2: the Moloney murine leukemia virus (M-MuLV) and the simian immunodeficiency virus (SIV). 139 However, a study performed in 2003 tested a series of fullerene derivatives (13 in total, compounds 1–13) against HIV-1 and HIV-2. The results of that study showed that some of these CBNs (6 ( trans -2), 7 ( trans -3), 8 ( trans -4), 9 ( equatorial ), 12 ( trans -2)) exhibited potent antiviral activity against HIV-1 but not HIV-2 in the low micromolar concentration range.…”

Section: Antiviral Properties Of Carbon-based Materialsmentioning

confidence: 99%

Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era

et al. 2021

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Therapeutic options for the highly pathogenic human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the current pandemic coronavirus disease (COVID-19) are urgently needed. COVID-19 is associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. The proposed treatments for COVID-19 have shown little or no effect in the clinic so far. Additionally, bacterial and fungal pathogens contribute to the SARS-CoV-2-mediated pneumonia disease complex. The antibiotic resistance in pneumonia treatment is increasing at an alarming rate. Therefore, carbon-based nanomaterials (CBNs), such as fullerene, carbon dots, graphene, and their derivatives constitute a promising alternative due to their wide-spectrum antimicrobial activity, biocompatibility, biodegradability, and capacity to induce tissue regeneration. Furthermore, the antimicrobial mode of action is mainly physical ( e.g. , membrane distortion), characterized by a low risk of antimicrobial resistance. In this Review, we evaluated the literature on the antiviral activity and broad-spectrum antimicrobial properties of CBNs. CBNs had antiviral activity against 13 enveloped positive-sense single-stranded RNA viruses, including SARS-CoV-2. CBNs with low or no toxicity to humans are promising therapeutics against the COVID-19 pneumonia complex with other viruses, bacteria, and fungi, including those that are multidrug-resistant.

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“…Functionalized tetrapodlike ZnO nanostructures and single-walled carbon nanotubes were found to increase PCR yield [5][6]. C60 nanometre spheres and their derivatives were able to inhibit the replication of simian immunodeficiency virus (SIV) in vitro and the activity of Moloney murine leukaemia virus (M-MuLV) reverse transcriptase [7]. Our previous works showed carbon nanopowder (CNP) improved the amplification efficiency for long PCR reactions [8].…”

Section: Introduction (Heading 1)mentioning

confidence: 99%

Carbon Nanopowder Binds with DNA and May Induce DNA Aggregation

Guo

Liu

et al. 2010

2010 4th International Conference on Bioinformatics and Biomedical Engineering

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The interaction between nanomaterials and genomes is getting more and more attention. Such studies are getting involved into several fields: environment safety, food safety, nanobiotechnology and drug development. Direct interaction between nanoparticles and DNA in vitro has been reported in several studies, but data for in vivo binding between genomic DNA and nanoparticles are rare. In this study, we presented that carbon nanopowder (CNP) is able to bind with DNA both in vitro and in vivo. Interestingly, CNP binds to DNA with a relatively high density and may induce DNA aggregation.

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Antiretroviral Effects of Nonderivatizcd C_6oIn Vitro

Cited by 13 publications

References 7 publications

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era

Carbon Nanopowder Binds with DNA and May Induce DNA Aggregation

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Antiretroviral Effects of Nonderivatizcd C6oIn Vitro

Cited by 13 publications

References 7 publications

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era

Carbon Nanopowder Binds with DNA and May Induce DNA Aggregation

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Antiretroviral Effects of Nonderivatizcd C_6oIn Vitro