Antiretinal antibodies in central serous chorioretinopathy: prevalence and clinical implications

Berge, J; Dijk, Elon H. C. van; Schreurs, Marco W. J.; Vermeer, Jacolien; Boon, Camiel J F; Rothová, Aniki

doi:10.1111/aos.13445

Cited by 8 publications

(6 citation statements)

References 48 publications

(38 reference statements)

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“…One recent suggestion was that damage to the RPE outer-retinal blood barrier in CSC results in the secondary formation of anti-retinal antibodies, which may affect the clinical course of CSC. Anti-retinal antibodies were found in 54% of CSC patients, versus 17% of healthy controls, but no association between clinical characteristics and the presence of anti-retinal antibodies was found (Ten Berge et al 2018). Consequently, although it remains controversial whether retinal epitheliopathy precedes choroidopathy or vice versa, the fact remains that RPE integrity has a vital defensive role to play against the elevated choroidal hydrostatic pressure seen in this disease.…”

Section: Rpe Dysfunctionmentioning

confidence: 97%

Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities

Kaye

Chandra

Sheth

et al. 2020

Progress in Retinal and Eye Research

139

196

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Section: Rpe Dysfunctionmentioning

confidence: 97%

Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities

Kaye

Chandra

Sheth

et al. 2020

Progress in Retinal and Eye Research

139

196

View full text Add to dashboard Cite

show abstract

“…The RPE can be damaged by ischaemia from the compression of choriocapillaris, but direct injury can also be caused by dysregulation of the complement or adrenergic pathway, which could then lead to disruption of ion channels such as aquaporins, PEDs, RPE micro‐rips, or atrophy 58 . Damage to the RPE may result in secondary formation of anti‐retinal antibodies, which have been found in 54% of CSC patients versus 17% of healthy controls, but the clinical significance of this is not clear 59 …”

Section: Pathogenesismentioning

confidence: 99%

“…58 Damage to the RPE may result in secondary formation of anti-retinal antibodies, which have been found in 54% of CSC patients versus 17% of healthy controls, but the clinical significance of this is not clear. 59…”

Section: Rpe Dysfunctionmentioning

confidence: 99%

Central serous chorioretinopathy: A review

Fung

Yang

Kam

2023

Clinical Exper Ophthalmology

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Central serous chorioretinopathy (CSC) is the fourth most common nonsurgical retinopathy associated with fluid leakage. The pathogenesis is not yet completely understood, but changes in the choroid, sclera and RPE have been described associated with venous congestion of choroidal outflow. CSC can be categorised into acute, chronic, and recurrent subtypes with recent classifications of simple and complex based on the area of RPE change seen on fundus autofluorescence. A multimodal imaging approach is helpful in the diagnosis and management of CSC and secondary complications such as type 1 neovascularisation. Although spontaneous resolution with relatively good visual outcomes is common, treatment should be considered in patients with persistent or recurrent SRF. Treatment options include laser, systemic medications, intravitreal therapy, and surgery. Of these, argon laser for focal extramacular fluid leaks and photodynamic therapy of leakage identified by indocyanine-green angiography currently have the greatest supportive evidence.

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“…Autoimmunity has been implicated in the pathogenesis of CSC. [ 58 59 ] Ten Berge et al . considered the presence of anti-retinal antibodies an epiphenomenon resulting from induction of autoimmunity following the exposure of otherwise sequestered antigens or molecular mimicry.…”

Section: Immune Mechanisms In Central Serous Chorioretinopathymentioning

confidence: 99%

“…considered the presence of anti-retinal antibodies an epiphenomenon resulting from induction of autoimmunity following the exposure of otherwise sequestered antigens or molecular mimicry. [ 58 ] The reported risk (odds ratio: 6.2) of CSC with previous antibiotic use could signify the presence of infectious agents exhibiting molecular mimicry. [ 60 ] The presence of anti-endothelial cell antibodies possibly signifies endothelial dysfunction and hyperpermeability in CSC.…”

Section: Immune Mechanisms In Central Serous Chorioretinopathymentioning

confidence: 99%

Central serous chorioretinopathy: Pathophysiology, systemic associations, and a novel etiological classification

Jain¹,

Mohan

Dijk

2022

Taiwan J Ophthalmol

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Central serous chorioretinopathy (CSC) has remained an enigmatic disease since its initial description by Von Graefe. Over the years, multiple risk factors have been recognized: these include psychological stress, behavioral traits, and corticosteroids. The basic pathophysiology of CSC involves choroidal thickening, vascular congestion, altered choroidal blood flow (ChBF), and choroidal hyperpermeability, leading to retinal pigment epithelium decompensation and subsequent neurosensory detachment. Multiple organ systems, mainly the nervous, cardiovascular, endocrinal, and renal systems participate in the control of the vascular tone and the ChBF via hypothalamus–pituitary–adrenal axis and renin–angiotensin–aldosterone system, while others such as the hepatic system regulate the enzymatic degradation of corticosteroids. Many vasoactive and psychotropic drugs also modulate the ocular perfusion. In addition, there are anatomical and genetic predispositions that determine its progression to the chronic or recurrent form, through cellular response and angiogenesis. We herein review the basic pathophysiology and immunogenetics in CSC along with the role of multiple organ systems. With this background, we propose an etiological classification that should provide a framework for customized therapeutic interventions.

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Antiretinal antibodies in central serous chorioretinopathy: prevalence and clinical implications

Cited by 8 publications

References 48 publications

Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities

Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities

Central serous chorioretinopathy: A review

Central serous chorioretinopathy: Pathophysiology, systemic associations, and a novel etiological classification

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