Antiradical and antioxidative effect of arginine and its influence on lipid peroxidation activity during hypoxia

Milyutina, N. P.; Ananyan, A. A.; Shchugalei, V. S.

doi:10.1007/bf00840280

Cited by 7 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, this antioxidant effect may be due to their arginine (Arg) content (180–310 g kg −1 ) (Table ). Arginine has shown antioxidant properties due to its guanidine group . On the other hand, F1F (275 g Arg kg −1 ) showed capability to inhibit copper‐mediated oxidation only in the LDL system.…”

Section: Discussionmentioning

confidence: 99%

“…Arginine has shown antioxidant properties due to its guanidine group. 30 -32 On the other hand, F1F (275 g Arg kg −1 ) showed capability to inhibit copper-mediated oxidation only in the LDL system. This may be due to the small molecular size of this fraction, approximately in the free amino acid range, 20 which does not favor hydrogen donation from the guanidine group with the same efficiency as peptides with three to four amino acids.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chickpea chelating peptides inhibit copper‐mediated lipid peroxidation

2014

View full text Add to dashboard Cite

BACKGROUND Transition metals produce radical oxygen species promoting lipid peroxidation processes that favor the development of cardiovascular and neurodegenerative diseases. In addition, the oxidation of lipids present in food may affect the quality of food products. Therefore antioxidants counteracting these metal pro‐oxidant effects may have high potential for the pharmacology and food industries. This study investigated the capability of peptide fractions purified from chickpea protein hydrolysate to inhibit copper‐mediated lipid peroxidation in three different lipid substrates: β‐carotene, unsaturated fatty acid mixture and low‐density lipoprotein. RESULTS Peptide fractions with the highest histidine content were the most antioxidant. This antioxidant effect is mainly due to the capability of histidine to bind copper and act as a hydrogen donor through its imidazole ring. CONCLUSION The results suggest that chickpea proteins are a potential source of antioxidant peptides that may be included as ingredients in functional foods with beneficial health effects. In addition, these antioxidant peptides may be useful to protect food products from lipid peroxidation processes and thus increase their quality and shelf life. © 2014 Society of Chemical Industry

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chickpea chelating peptides inhibit copper‐mediated lipid peroxidation

2014

View full text Add to dashboard Cite

show abstract

“…Its cationic nature contributes to the unique protonative properties and ability to react directly with the superoxide anion radical (84). Thus, arginine and its derivatives regulate membrane peroxidation processes (85). Although the human cells are capable of synthesizing arginine, its external supplementation is necessary for infants and the elderly, making arginine conditionally essential (86).…”

Section: A Contribution Of the Urea Cycle And Polyamine Metabolic Patmentioning

confidence: 99%

A New Perspective on Alzheimer’s Disease as a Brain Expression of a Complex Metabolic Disorder

Polis

Samson

2019

Alzheimer’s Disease

View full text Add to dashboard Cite

Alzheimer' s disease (AD) is an irredeemable chronic neurodegenerative disorder and the predominant cause of dementia. The disease progression is associated with the deposition of amyloid plaques and formation of neurofibrillary tangles in the brain, yet clinical dementia is the end and culminating stage of the enduring pathology. Recent evidence suggests that AD is characterized by distinctive abnormalities apparent on systemic, histological, macromolecular, and biochemical levels. Besides the well-described characteristic profuse neurofibrillary tangles, dystrophic neurites, and Aβ deposits, the AD pathology includes substantial neuronal loss, inflammation, extensive DNA damage, considerable mitochondrial malfunction, impaired energy metabolism, and chronic oxidative stress. Moreover, severe metabolic dysfunction leading to oxidative stress is a possible cause and hallmark of AD that is apparent decades before the disease manifestation. State-of-the-art metabolomics studies have proved that arginine and branched-chain amino acids metabolism disturbances accompany AD and contribute to its pathogenesis. Repetitive failures to find an efficient anti-amyloid or anti-Tau treatment, which would face the challenges of the complex AD pathology, led to the hypothesis that hyperphosphorylated Tau and deposited

show abstract

“…Pretreatment by L-Arg prevented TBARS accumulation induced by hemin while SNP did not affect this parameter. The antioxidant and antiradical properties of L-Arg were shown in model systems both in vitro and in vivo wherein L-Arg was able to limit superoxide formation and lipid peroxidation (Milutina et al, 1990). On the other hand, L-Arg can be utilized for synthesis of NO that has dual antioxidant role.…”

Section: Resultsmentioning

confidence: 99%

In vivo effects of hemin and nitric oxide donors on parameters of heme metabolism in rat liver and serum

2018

The Journal of v. N. Karazin Kharkiv National University, Series "Biology"

View full text Add to dashboard Cite

In vivo effects of hemin chloride (15 mg/kg body weight) and donors of nitrogen monoxide (NO) – sodium nitroprusside (SNP, 1 mg/kg) and substrate of NO-synthase L-arginine (L-Arg, 600 mg/kg) on the activity of key enzymes of heme synthesis (5-aminolevulinate synthase, ALAS) and heme degradation (heme oxygenase, HO), on the free heme level in liver and on the content of heme in blood serum of rats were studied. NO donors were administered alone or 30 min before hemin chloride injection. The level of free heme in liver was estimated by the ratio of holoenzyme and total tryptophan 2,3-dioxygenase (TDO) activities. Two hours after hemin chloride administration a significant increase in the level of heme-containing products and lipid peroxidation products (TBARS) was found in blood serum. These changes were accompanied by decrease in ALAS activity and by increase in holoenzyme activity and heme saturation of TDO, which was the result of free heme accumulation in liver. 24 hrs after administration of hemin chloride the content of heme in serum returned to normal level, while level of TBARS remained elevated. 24 hrs after hemin action a significant increase in the activities of HO and ALAS was observed in liver, while the degree of TDO heme saturation decreased, indicating the prevalence of heme degradation over its synthesis. Both NO donors did not affect the accumulation of heme in serum and liver first hours after hemin action. However, the specific features of SNP and L-Arg effects on the key enzyme of heme synthesis in liver and the TBARS level in serum were revealed. L-Arg, unlike SNP, prevented the accumulation of TBARS in serum, but did not prevent a decrease in ALAS activity 2 hrs after hemin chloride injection. The treatment by SNP itself caused an increase in TBARS level in serum, an increase in TDO activity and a decrease in ALAS activity in liver 2 hrs after action. Heme content in serum positively correlated with holoenzyme activity and heme saturation of TDO in liver. The pretreatment with NO donors did not affect the increase in HO activity, however, it blocked the induction of ALAS, a decrease in holoenzyme activity and heme saturation of TDO 24 hrs after the administration of hemin chloride. Thus, both SNP and Arg prevented a decrease in free heme level in liver, which might be due to heme nitrosylation in the presence of NO donors and, as a result, its slower degradation in the heme oxygenase reaction.

show abstract

Antiradical and antioxidative effect of arginine and its influence on lipid peroxidation activity during hypoxia

Cited by 7 publications

References 6 publications

Chickpea chelating peptides inhibit copper‐mediated lipid peroxidation

Chickpea chelating peptides inhibit copper‐mediated lipid peroxidation

A New Perspective on Alzheimer’s Disease as a Brain Expression of a Complex Metabolic Disorder

In vivo effects of hemin and nitric oxide donors on parameters of heme metabolism in rat liver and serum

Contact Info

Product

Resources

About