Antiradical Activity of Porphyrins with a Diisobornylphenol Fragment at the Macrocycle Periphery

Abstract

This article focuses on the antiradical activity of a number of 2,6-diisobornylphenol-porphyrin conjugates with various spacers between the porphyrin and phenolic fragments in the model reaction of ethylbenzene oxidation initiated by azoisobutyric acid dinitrile. The study has shown that the electronic effects of the groups directly related to the 2,6-diisobornylphenol fragment exert the predominant influence both on the reactivity of the phenolic hydroxyl group in interaction with free radicals and on the antiradical activity of the molecule as a whole. The antiradical activity of the molecule is generally less affected by the nature of the substituents in the porphyrin macrocycle, mainly due to a change in the stoichiometric inhibition coefficient in the presence of relatively easily oxidizable groups. It was found that the length of the spacer between the porphyrin and phenolic fragments does not affect the antiradical activity of the conjugate.

Synthesis and Antioxidant Ability of Novel Derivatives Based on para‐Coumaric Acid Containing Isobornyl Groups

“…During the experiments on laboratory animals, compound 1 showed rheologic activity in ischemia/reperfusion conditions and cardioprotective properties . There have also been earlier cases of using 2,6‐diisobornyl‐4‐methylphenol ( 1 ) in the synthesis of new derivatives . In addition, it is known from literature that phenol‐based drugs with an isobornyl substituent are being developed …”

1H NMR Quantitative Determination of Chlorophyll a in the Spirulina Biomass

“…В качестве объекта исследования выбрана воздушносухая биомасса спирулины (производство «Frontier co-op», Норвегия), использованная нами ранее в качестве сырья для получения феофитина а (1) [35] и метилфеофорбида а (2). [6,[45][46][47][48][49][50][51] Спектры ЯМР 1 Н записывали на спектрометре «Bruker Avance II 300» (300. Определение массовой доли хлорофилла а в биомассе спирулины.…”