Antiradical activity of cinnamic acid derivatives

Avanesyan, A. A.; Пашков, А. Н.; Simonyan, N. A.; Simonyan, A. V.; Myachina, Olga

doi:10.1007/s11094-009-0285-0

Cited by 11 publications

(7 citation statements)

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“…Specifically, the compound correlated significantly with the FRAP assay (0.907; p < 0.05), anti-glycation activities (0.90–0.96; p < 0.05), CAA (0.94–0.98; p < 0.05), as well as isoprostane levels (0.88–0.89; p < 0.05). The present data were supported by previous findings that reported moderate radical quenching activities of cinnamic acid owing to the absence of the hydroxyl group on the aromatic ring [42,43]. The ability of cinnamic acid to undergo a reduction mechanism, nevertheless, afforded the strong positive correlations between the compound with the FRAP assay and anti-glycation activities [44].…”

Section: Resultssupporting

confidence: 90%

Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent

et al. 2016

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Increasing evidence from both experimental and clinical studies depicts the involvement of oxidative stress in the pathogenesis of various diseases. Specifically, disruption of homeostatic redox balance in accumulated body fat mass leads to obesity-associated metabolic syndrome. Strategies for the restoration of redox balance, potentially by exploring potent plant bioactives, have thus become the focus of therapeutic intervention. The present study aimed to bioprospect the potential use of the curculigoside-cinnamic acid-rich fraction from Molineria latifolia rhizome as an antioxidant therapeutic agent. The ethyl acetate fraction (EAF) isolated from M. latifolia rhizome methanolic extract (RME) contained the highest amount of phenolic compounds, particularly curculigoside and cinnamic acid. EAF demonstrated glycation inhibitory activities in both glucose-and fructose-mediated glycation models. In addition, in vitro chemical-based and cellular-based antioxidant assays showed that EAF exhibited high antioxidant activities and a protective effect against oxidative damage in 3T3-L1 preadipocytes. Although the efficacies of individual phenolics differed depending on the structure and concentration, a correlational study revealed strong correlations between total phenolic contents and antioxidant capacities. The results concluded that enriched phenolic contents in EAF (curculigoside-cinnamic acid-rich fraction) contributed to the overall better reactivity. Our data suggest that this bioactive-rich fraction warrants therapeutic potential against oxidative stress-related disorders.

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Section: Resultssupporting

confidence: 90%

Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent

et al. 2016

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“…The production of flavors and fragrances through natural substances by an esterification process is a subject of scientific and industrial interest . Owing to the fact that lipases (triacylglycerol ester hydrolasesE.C.…”

Section: Introductionmentioning

confidence: 99%

“…Cinnamic acid derivatives typically have a broad spectrum of biological activity including antioxidant, cerebroprotective, hepatoprotective, cholegogic, anti‐inflammatory, cytostatic, antihypoxic, hypolipidemic, anticoagulant, anti‐allergic, antimicrobial, etc . and are widely used in food additives .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of geranyl cinnamate by lipase‐catalyzed reaction and its evaluation as an antimicrobial agent

Zanetti

Carniel

Valério³

et al. 2016

J of Chemical Tech & Biotech

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“…Cinnamic acid derivatives typically have a broad spectrum of biological activity including antioxidant, cerebro-protective, hepato-protective, cholegogic, antiinflammatory, cytostatic, anti-hypoxic, hypolipidemic, anti-coagulant, anti-allergic, antimicrobial, etc. [18] and are widely used in food additives [19]. Cinnamic acid is the main constituent of clove oil composing approximately (70 to 80%) followed by the composition of eugenol (4 to 7%) [20].…”

Section: Introductionmentioning

confidence: 99%

Microbiological Characterization of Pure Geraniol and Comparison with Bactericidal Activity of the Cinnamic Acid in Gram-Positive and Gram-Negative Bacteria

ZR¹

2015

J Microb Biochem Technol

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Geraniol is a terpene alcohol and the principal constituent compound of many essential oils of the aromatic plants. This molecule is very important for the flavors and fragrance industries due to its pleasant odor. The geraniol has the insecticidal properties and is an efficiently repellent agent and its toxicity is low. So, its antimicrobial ability can be explored to obtaining important additives for especial products applied in the food industry. The cinnamic acid is a molecule present in cinnamon oils and in coca leaves. This molecule also exhibits low toxicity and has a broad biological application spectrum for many microorganisms. This work evaluated the antimicrobial activity of the essential oil of geraniol and of the cinnamic acid against different microorganisms and compared their bactericidal activity for future applications as an additive for food packages. The bacteria studied were: Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Salmonella enterica. The Minimum Inhibitory Concentration test (MIC) and the Agar Diffusion Method were applied to available the antimicrobial susceptibility. The geraniol showed a large bactericidal activity and greater than the cinnamic acid for the bacteria studied. The geraniol showed the better bactericidal action and high application potential for use as an additive for treatment of the food or to produce active food packaging.

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Antiradical activity of cinnamic acid derivatives

Cited by 11 publications

References 0 publications

Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent

Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent

Synthesis of geranyl cinnamate by lipase‐catalyzed reaction and its evaluation as an antimicrobial agent

Microbiological Characterization of Pure Geraniol and Comparison with Bactericidal Activity of the Cinnamic Acid in Gram-Positive and Gram-Negative Bacteria

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