1969
DOI: 10.5925/jnsv1954.15.78
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Antirachitic Potency of Vitamin D Sulfate in Human Milk

Abstract: In the forgoing papers, the authors have reported the relation between vitamin D and active sulfate metabolism (1-4), and the isolation of vitamin D sulfate from mammalian milk (5). Further tests for the antirachitic potency of human milk (containing 780I.U. of total vitamin D in 2ml as determined by the authors) by prophyrachitic and curative methods using rats previously fed on a vitamin D -defficient diet showed the positive results both in X-ray and AOAC ash test .

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Cited by 31 publications
(9 citation statements)
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“…Human colostrum has twice the activity of mature milk and the concentration depends on the maternal diet (Macy, 1949;Macy & Kelly, 1961). The major contributor to vitamin D activity, which varies greatly, is vitamin D 3 (cholecalciferol) (DHSS, 1980), but there have been reports of a water-soluble vitamin D sulphate in both cow's and human milk (Sahashi et al 1967;Le Boulch el al. 1974;Lakdawala & Widdowson, 1977).…”
Section: Vitaminsmentioning
confidence: 99%
“…Human colostrum has twice the activity of mature milk and the concentration depends on the maternal diet (Macy, 1949;Macy & Kelly, 1961). The major contributor to vitamin D activity, which varies greatly, is vitamin D 3 (cholecalciferol) (DHSS, 1980), but there have been reports of a water-soluble vitamin D sulphate in both cow's and human milk (Sahashi et al 1967;Le Boulch el al. 1974;Lakdawala & Widdowson, 1977).…”
Section: Vitaminsmentioning
confidence: 99%
“…The figures are based on single determinations for each sample. Owing to the low levels of vitamin D 3 in milk and the difficulties in quantifying the peak (after HPLC analysis) with confidence, the concentrations may be subject to a similar error of up to 0015 fig/100 g. The presence of water soluble vitamin D sulphate has been reported by various workers (Sahashi et al 1969;Le Boulch et al 1974), but recently it has been shown that this water soluble fraction of cow's milk does not possess significant antirachitic activity (Leerbeck & Sondergaard, 1980;DeLuca, 1980). For the analysis reported here, any water soluble vitamin D was therefore removed from the sample before analysis.…”
Section: Resultsmentioning
confidence: 99%
“…Turton et al27 reported that nonpregnant white women had a mean 25-OHCC level of 9 ng/ml; 24 nmol/l (7-11 ng/ml (18 -7-29-4 nmol/l) ± 1 SEM after log transformation), and while at 20-30 weeks of pregnancy the mean value was 7 ng/ml; 18 7 nmol/l (6-9 ng/ml (16-24 nmol/l) ), by 30-40 weeks it had returned to 9 ng/ml (6)(7)(8)(9)(10)(11)(12). All values were performed in February, so seasonal effects were excluded.…”
Section: -Hydroxycholecalciferol Serum Levels In Breast-fed Infantsmentioning
confidence: 95%