Antipyretic Potential of Swertia chirata Buch Ham. Root Extract

Bhargava, Sushil; Rao, P. Sailaja; Bhargava, Paridhi; Shukla, Shiv Shankar

doi:10.3797/scipharm.0812-10

Cited by 45 publications

(19 citation statements)

References 8 publications

(6 reference statements)

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“…Likewise, Rheum australe, used to treat diarrhea/dysentery in the Humla district has been reported to be purgative, astringent and antiamoebic in nature by Reynolds (1982). Swertia chirayita, used to cure cough, cold, fever, malaria and headache in the Humla district, is mentioned as antipyretic or anti-inflammatory and antibacterial or antifungal in other studies (Chowdhury et al, 1995;Devkota et al, 1999;Bharyava et al, 2009). …”

Section: Reliability Of Reported Usesmentioning

confidence: 98%

Ethnobotanical study of medicinal plants from the Humla district of western Nepal

Rokaya

Münzbergová

Timsina³

2010

Journal of Ethnopharmacology

280

140

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Section: Reliability Of Reported Usesmentioning

confidence: 98%

Ethnobotanical study of medicinal plants from the Humla district of western Nepal

Rokaya

Münzbergová

Timsina³

2010

Journal of Ethnopharmacology

280

140

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“…1,2 S. chirata is used as antipyretic, anthelmintic, hypoglycemic, febrifuge, laxative, stomachic, tonic and in asthma and leucorrhoea. 2 The plant is also used in the treatment of hepatic disorders. 3,4 However, populations of S. chirata are diminishing and the plant has been considered as critically endangered.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Nag

Das²,

Das³

et al. 2015

Phcog J

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Aim:The aim of the study was to analyze the antioxidant, anti-amylase, anti-glucosidase and antiacetylcholinesterase (anti-AChE) properties of the leafy shoots of three Indian species of Swertia e.g. Swertia chirata and its substitutes Swertia bimaculata, and Swertia decussata, their xanthones and amarogentin. Methods: Antioxidant activity of the methanolic extracts of leafy shoots was measured in terms of DPPH, superoxide and nitric oxide radical scavenging activities as well as metal chelating properties. Enzyme inhibitory properties were measured using AChE, α-amylase and α-glucosidase respectively. Five xanthones bellidifolin (1), swerchirin (2), decussatin (3), mangiferin (4) and 1-hydroxy-3,5,8-trimethoxy xanthone (6) and one iridoid, amarogentin (5) were isolated from Swertia chirata. The activities of the isolated components were compared. Results: Swertia chirata exhibited best antioxidant and antiAChE properties than the other two species. The plants also possessed α-glucosidase inhibitory properties but weak α-amylase inhibitory activity. Highest activities were observed in Swertia chirata. We report here, for the first time, the antioxidant, anti-AChE and anti-glycosidase activity of 1-hydroxy-3,5,8-trimethoxy xanthone. This xanthone had strongest DPPH radical scavenging activity and anti-AChE property. Conclusion: The results suggest the beneficial effects of the xanthones of Swertia chirata. But further study should be carried out to prove the efficacy in vivo.

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“…A large proportion of the world's population, around 80% use traditional medicines for their health care needs [7]. The plant S. chiraita has been prized in mountainous country like Nepal and China as a tonic medicine and has been reported to possess anticarcinogenic [8]; hypoglycemic [9]; antihepatoxic [10]; antihelmintic [11]; anti-inflam-imatory [12], antipyretic [13] and antiviral [14] properties. Due to its medicinal importance and trade value the plant S. chiraita already has been vulnerable and endangered in Nepal [15] as people harvest indiscriminately from its wild habitat.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Antimicrobial Screening of Native Plant Swertia chirayita (Roxb. ex Fleming) Karst from Rasuwa district of Nepal

Subedi¹,

Karki

2018

J.Trop.Life.Science

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Swertia chirayita is one of the highly traded medicinal plants of Nepal. This plant was chosen for investigation as folk medicines and then collected from the diverse habitats of Rasuwa district of Nepal and specimens have been checked and identified at National Herbarium and Plant Laboratories (NHPL), Godavari, Lalitpur. The identified plant was subjected to study physiochemical and biological activity. The stem, root and leaves of the plant were dried, made powder and mixed at the ratio of 1 : 1 : 1 and then extracted using methanol solvent by cold and warm method. The percentage yield from the plant was highest in warm methanol with 3.73%, followed by cold methanol with 2.28%. Plant extract showed the presence of phytochemicals like basic alkaloids, coumarin, glycosides, steroids, quinones, flavonoid and terpenoids. The antibacterial activity of the extract showed significant bioactive by inhibiting the growth of selected pathogenic microbial species for the test. The zone of inhibition (ZOI) shown by the extracts was comparable to the standard antibiotics. Similarly, proximate composition was also carried out. The antioxidant activity of the sample was found to be 62.54% at 500 µg/mL and 15.32% at 100 µg/mL by radical scavenging method and showed significant antioxidants potential.

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Antipyretic Potential of Swertia chirata Buch Ham. Root Extract

Cited by 45 publications

References 8 publications

Ethnobotanical study of medicinal plants from the Humla district of western Nepal

Ethnobotanical study of medicinal plants from the Humla district of western Nepal

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Phytochemical and Antimicrobial Screening of Native Plant Swertia chirayita (Roxb. ex Fleming) Karst from Rasuwa district of Nepal

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