Antipyretic Effect of Rauwolfia Vomitoria in Rabbits

Amole, O.O.; Onabanjo, A. O.

doi:10.4314/njnpm.v3i1.11768

Cited by 8 publications

(5 citation statements)

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“…The sedative property is attributed to its ability to balance body response to stress and anxiety and to increase oxygen delivery to the brain [8]. Constituents like alkaloid, and alstonine, find in the root and leaves of R. vomitoria have anticancer properties [9] and antipyretic effect is known [10]. The roots and leaves of the plant are used for treatment cholera and liver diseases [11].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective and Antioxidant Effects of Aqueous Extract of Rauwolfia vomitoria (Apocynaceae) Stem Bark in Wistar Rats

Djanche

Sanda

Fotsing

et al. 2021

J. Pharm. Med. Res.

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Rauwolfia vomitoria is used in Cameroon in indigenous medicine to treat liver diseases. The present study was carried out on the hepatoprotective and antioxidant effects of the plant aqueous extract. Liver toxicity was induced by oral route administration of CCl4 two times per week for four weeks. Rats were given concomitantly by oral route, aqueous extract at the doses of 100, 200 and 300 mg/kg or silymarin four days a week for four weeks. By the end, bloods were collected for liver functional parameters analyses. Liver tissues were removed, to assess to oxidative stress parameters and histological analyses. The extract (300 mg/kg) decreased enzyme activity of ALT, AST and the level of TG with the percentage 54.23%, 49.63% and 28.74% respectively while it increased the enzyme activity of SOD, CAT and level of MDA at about 67.16%, 71.42% and 43.80% respectively compared to control animals. These results suggested that aqueous extract has strong hepatoprotective effect on CCl4-induced liver damage and increase antioxidant defense system activity.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective and Antioxidant Effects of Aqueous Extract of Rauwolfia vomitoria (Apocynaceae) Stem Bark in Wistar Rats

Djanche

Sanda

Fotsing

et al. 2021

J. Pharm. Med. Res.

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“…vomitoria is commonly used locally in the treatment of snake and insect bites, and is reported to protect the body generally (Obembe, 2001;Amoateng et al, 2018). Reported researches on RV shows that it promotes body weight loss, lowers blood pressure, sedates and detoxifies, as well as being antipyrexic among others (Amole and Onabanjo, 1999;Eluwa et al, 2008;Ekong et al, 2015a). Previous studies have also showed that RV ameliorated neurotoxicity caused by chlorpromazine and Sida acuta leaf extract (Ajao et al, 2015;Okon et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Hippocampal Histomorphology Following R. vomitoria Root Extract Treatment

Ekong

Ekpene

Nwakanma

et al. 2020

IJMSS

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Rauwolfia vomitoria Afzel. is an antipsychotic plant used by several African communities in the management of psychiatric conditions with good outcomes. Concerns about its dosages on brain activity lead to this investigation of its action on the hippocampal microstructure. Twenty-four adult male Wistar rats of average weight 200 g, were assigned into four groups (n = 6): control; 200, 300 and 400 mg/kg body weight of RV root bark extract, respectively. The administration was once daily, and orally for seven days. Daily observation of the animals was done till on day eight when they were sacrificed after deep anaesthesia. Each brain was processed for histology and immunohistochemical studies. Animals in the 200, 300 and 400 mg/kg RV groups appeared generally dull and drowsy, and barely fed. Their hippocampal histology showed neuronal atrophy and karyorrhexis, with no difference in cell count, although the pyramidal cell numbers decreased in the 300 and 400 mg/kg RV groups. Neuron-specific enolase decreased in the 400 mg/kg RV group, while neurofilament decreased in all test groups. Glial fibrillary acidic protein expression and density increased in the 200 and 300 mg/kg RV groups, but not the 400 mg/kg RV group, all compared with the control group. The given doses of RV root bark extract in adult Wistar rats showed sedative activities with hippocampal histopathological changes, which may not be reversible, thereby leading to the hippocampal functional deficit.

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“…Extensive studies carried out on its chemical properties showed that this plant contains more than 50 active indole alkaloids, each possessing remarkable physiological and pharmacological activities [4]. A bioactive ß-carboline alkaloid, alstonine, present in the root and leaf were shown to have anti-cancer activity [5,6] while the antipyretic effect of leaf extract has also been demonstrated [7]. The pharmaceutical derivatives are used mainly as antihypertensive and sedatives.…”

Section: Introductionmentioning

confidence: 99%

Acute and sub-acute toxicity of the aqueous extract of the stem bark of Rauwolfia vomitoria (Apocynaceae) in Wistar rats.

Bonheur¹,

Désiré²,

Antoine³

et al. 2020

World J. Adv. Res. Rev.

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The present study investigated the toxicological potential of the oral administration of the stem bark aqueous extract of R. vomitoria on the liver and kidney in rats. Acute oral toxicity study of the extract to a single dose of 2000 mg/kg was studied in 10 rats of both sexes. Sub –acute oral toxicity of aqueous extract of was carried out on 60 rats. We constituted 4 groups of 10 rats each (5 males and 5 females) which were orally administered 300, 600, and 900 mg/kg of aqueous extract and control group received water. 2 group satellites (SAT) of 10 rats each (5 males and 5 females) in which one group (SAT 900 mg/kg) was received orally 900 mg/kg of aqueous extract and another (SAT control) water. Serum blood was collected for biochemical and haematological parameters. The liver and kidney served for histological examination. No deaths of acute oral toxicity were recorded. In female rats, Aspartate Aminotransferase (ASAT) activity increased by 31.20 % and Alamine Aminotransferase (ALAT) increased by 37.20 %. In male rats, only ALAT activity increased significantly by 35.37 % compared to control. Haematological analysis revealed in male rats treated at the dose of 900 mg/kg an increase significant (p<0.001) level of white blood cells with 52.20 %, compared to control group. Histological examination of liver and kidney showed normal architecture. Aqueous extract has untoward effect on liver and kidney, could be considered non-toxic.

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Antipyretic Effect of Rauwolfia Vomitoria in Rabbits

Cited by 8 publications

References 0 publications

Hepatoprotective and Antioxidant Effects of Aqueous Extract of Rauwolfia vomitoria (Apocynaceae) Stem Bark in Wistar Rats

Hepatoprotective and Antioxidant Effects of Aqueous Extract of Rauwolfia vomitoria (Apocynaceae) Stem Bark in Wistar Rats

Characterization of Hippocampal Histomorphology Following R. vomitoria Root Extract Treatment

Acute and sub-acute toxicity of the aqueous extract of the stem bark of Rauwolfia vomitoria (Apocynaceae) in Wistar rats.

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