Antipyretic and anti-asthmatic activities of traditional Chinese herb-pairs, Ephedra and Gypsum

Mei, Fen; Xing, Xuefeng; Tang, Qinglian; Chen, Feilong; Guo, Yang; Song, Shuai; Tan, Xiaomei; Jia-bo, Luo

doi:10.1007/s11655-014-1952-x

Cited by 35 publications

(21 citation statements)

References 16 publications

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“…12 In this case, we chose HerbaEphedrae (Ma Huang), Gypsum Fibrosum (Shi Gao) and Radix Glycyrrhizae (Gan Cao) as the major components of our mixture because of their antipyretic and anti-asthmatic effects. 13 We added Yu Xing Cao (Houttuyniacordata), Huang Qin (Radix Scutellariae), Mu Dan Pi (Cortex Mountan), Sang Bai Pi (Cortex Mori), and Gua Lou Shi (Fructus Trichosanthis) to increase the antipyretic and antiinflammatory effects. We added Ting Li Zi (SemenLepidii) and Fu Ling (Poria Cocos) to improve the edema status of this patient and Huang Qin (Scutellariae Radix) and Mu Dan Pi (Moutan Cortex) to ameliorate lung inflammation, based on the results of previous investigations.…”

Section: Discussionmentioning

confidence: 99%

Adjuvant therapy with traditional Chinese medicine in a heart failure patient complicated by hospital-acquired pneumonia: A case report

Chen

Chuang

Huang

et al. 2019

Complementary Therapies in Medicine

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Objective: We report a case of congestive heart failure complicated by hospital-acquired pneumonia that was successfully treated with traditional Chinese medicine (TCM) and antibiotics. Clinical features and outcome: A 33-year-old man with a history of heart failure developed pneumonia during hospitalization. After the standard antibiotic therapy for 3 days, he continued to experience persistent fever and progressive cough with purulent sputum. Broad spectrum antibiotics did not relieve the fever or the purulent sputum; therefore, the patient requested TCM for integrated therapy, and was subsequently treated with a regiment of "clearing heat and damp excreting" decoction according to TCM theory. After three days of TCM combination therapy, the pneumonia patches significantly improved on chest X-ray. His sputum was obviously decreased in amount and the fever was complete remission in the 5 th day of TCM adjuvant therapy. Conclusion: Integrated therapy with a "clearing heat and damp excreting" decoction may have improved hospital-acquired pneumonia in a patient comorbid with congestive heart failure. The anti-pyretic, anti-inflammatory, antitussive and diuretic effects of TCM may be responsible for the observed improvement. Further experimental studies are warranted to confirm the efficacy and mechanism of TCM action in the treatment of pneumonia.

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Section: Discussionmentioning

confidence: 99%

Adjuvant therapy with traditional Chinese medicine in a heart failure patient complicated by hospital-acquired pneumonia: A case report

Chen

Chuang

Huang

et al. 2019

Complementary Therapies in Medicine

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“…Glycyrrhetic acid, a major ingredient of licorice, possesses anti-pyretic effects in Brewer’s yeast-induced fever in rats via the pituitary adrenal axis [35]. The herb pairs, Ephedrae and Gypsum, significantly attenuated Brewer’s yeast-induced fever in rats [36]. Therefore, it can be suggested that MXGST possesses anti-pyretic effects via the synergic effects of its medicinal components, especially Gypsum and Ephedrae [8, 36], and this effect might be mediated through the modulation of prostaglandin E 2 synthesis in the hypothalamus adrenal gland axis from glycyrrhizic acid and Gypsum [34, 35].…”

Section: Discussionmentioning

confidence: 99%

Antitussive, anti-pyretic and toxicological evaluation of Ma-Xing-Gan-Shi-Tang in rodents

Lin

Chang

2016

BMC Complement Altern Med

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BackgroundMa-Xing-Gan-Shi-Tang (abbreviated as MXGST), an important Chinese herbal prescribed for cough, bronchial inflammation and fever from pneumonia, consists of four medicinal herbs, including Ephedrae herb, Semen Pruni Armeniacae, licorice and Gypsum. These components, especially Ephedrae and Semen Pruni Armeniacae, possess antitussive activities, but they have severe adverse effects.MethodsThe pharmacological activities of MXGST extract in clinical use were investigated with citric acid-induced cough, acetylcholine/histamine-induced bronchial contraction and lipopolysaccharide (LPS)-induced fever in rodents. The subacute toxicology of MXGST extract was evaluated after a 28-day repeated oral administration in rats.ResultsEach gram of MXGST extract contained 60 ± 8 μg of ephedrine, 480 ± 40 μg of glycyrrhizic acid and 440 ± 8 μg of amygdalin according to high performance liquid chromatography and a photodiode array detector. MXGST extract produced pronounced, dose-dependent antitussive effects in guinea pigs and reduced hyperthermic syndrome induced by LPS in rats. MXGST extract blocked the bronchial contraction induced by acetylcholine/histamine. Oral administration of MXGST extract for 28 days did not cause any hematological, biochemical or histological changes in rats.ConclusionsMXGST extract is a safer, more effective Chinese prescription with antitussive and anti-pyretic effects. The antitussive mechanism of MXGST is related to partially relaxing the bronchial smooth muscle by blocking acetylcholinergic and histaminergic receptors.

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Section: 13mentioning

confidence: 96%

“…22 It has been found that the ephedra extract has anti-pyretic and anti-asthmatic activity in Wistar rats and it decreased ulcer healing time in rats. 23 Antibacterial inhibition was also noted as an effect of EA on B. subtilis, M. catarrhalis and methicillinresistant and non-resistant S. aureus bacteria. 24,25 Ephedra decreased NF-κB p65 activity leading to alleviation of lung damage and regulation of the cytokine production (IL-2 elevation and IL-1β, IFN-γ and TNF-α mRNA inhibition in lung tissues).…”

Section: Introductionmentioning

confidence: 96%

In vitro evaluation of anti-inflammatory and antioxidant effects of Asparagus aphyllus L., Crataegus azarolus L., and Ephedra alata Decne.in monocultures and co-cultures of HepG2 and THP-1-derived macrophages

Kmail¹,

Lyoussi²,

Zaid³

et al. 2017

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Introduction: Asparagus aphyllus L.,Crataegus azarolus L., and Ephedra alata Decne.have been used in traditional Greco-Arab herbal medicine to treat various metabolic and inflammatory diseases. However, to our knowledge, no scientific evidences regarding their anti-inflammatory effects have been published yet.This study aimedto evaluate the antioxidant and anti-inflammatory properties of Asparagus aphyllus L., Crataegus azarolus L., and Ephedra alata Decne.extracts using in vitro mono and co-culture systems. Methods: In the first phase of the current study we measured the total phenol, flavones and flavonol contents as well as the antioxidant activity using the DPPH scavenging assay, ABTS assay, and reducing power of the three plant extracts. In second phase, we used THP-1-derived macrophages as a monoculture and co-culture with hepatic cell line (HepG2) to assess the effects of the three plant extracts on the production of LPSinduced pro-inflammatory (IL-6 and TNF -) and anti-inflammatory (IL-10) cytokines.Results: All three extracts exhibit relatively high levels of phenolics, flavones and flavonols, which correlate with their antioxidant capacities.All three extracts were found to modulate the secretion levels of TNF -, IL-6 and IL-10 at non-toxic concentrations as measured with MTT and LDH assays. Conclusion: Taken together, our results suggest that the traditional uses of these extracts as anti-inflammatory remedies may be mediated by their significant antioxidant capacity, inhibition of pro-inflammatory cytokines secretion concomitant with enhancement of anti-inflammatory cytokines secretion.Key words: Anti-inflammatory, Antioxidant; Asparagus aphyllus L.; Crataegus azarolus L.;Ephedra alata Decne. INTRODUCTIONInflammation is the first response of the immune system to infection, irritation, as well as to various other diseases such as cancer, cardiovascular diseases, obesity, hypertension, diabetes, autoimmune, and neurodegenerative disorders.1 it involves directed migration and activation of leukocytes (neutrophils, monocytes and eosinophils) to the site of damage. Inflammation is linked to oxidant/antioxidant imbalance (an elevation in the reactive oxygen speciesin parallel to low levels of antioxidants). High levels of inflammatory markers and low level of antioxidants are observed in many inflammatory diseases 2,3 as well as in many pathological conditions such as malignancy, cardiovascular disease, diabetes type 2, kidney malfunction, gastrointestinal disorders, microbial infection, fibrogenesis, and neurological diseases. The imbalance between production of antioxidants versus getting rid of free radical species leads to oxidative stress. [4][5][6] Inflammation is driven by the release of a wide range of pro-inflammatory mediators, such as the pro-inflammatory cytokines IL-1β, IL-TNF-α, IL-6, IL 8, and IFN-γ. Anti-inflammatory cytokines that includes IL-1 receptor antagonist, IL-4, IL-6, IL-10, IL-11, and IL-13 down regulate the inflammatory response. Chemo-therapeutic anti-inflammatory dr...

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Antipyretic and anti-asthmatic activities of traditional Chinese herb-pairs, Ephedra and Gypsum

Abstract: These findings indicate that the Ephedra-Gypsum extract has antipyretic and anti-asthmatic properties. Hence, the results support additional scientific evidence in prescriptions.

Cited by 35 publications

References 16 publications

Adjuvant therapy with traditional Chinese medicine in a heart failure patient complicated by hospital-acquired pneumonia: A case report

Adjuvant therapy with traditional Chinese medicine in a heart failure patient complicated by hospital-acquired pneumonia: A case report

Antitussive, anti-pyretic and toxicological evaluation of Ma-Xing-Gan-Shi-Tang in rodents

In vitro evaluation of anti-inflammatory and antioxidant effects of Asparagus aphyllus L., Crataegus azarolus L., and Ephedra alata Decne.in monocultures and co-cultures of HepG2 and THP-1-derived macrophages

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