Antipyretic and Analgesic Activities of Sphenoceutrum Jollyanum

Muko, K.N.; Ohiri, PC; Ezugwu, CO

doi:10.4314/njnpm.v2i1.11785

Cited by 7 publications

(9 citation statements)

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“…The plant is also documented for the treatment of different human diseases including chronic coughs, worms, and other inflammatory conditions as well as tumour 8,9 . It is also believed to be an emetic and purgative; the sap is believed to relieve stomach ache and constipation, and to boost appetite and sexual drive 10 . In Cote d' Ivoire, pounded roots are taken against high blood pressure, while the boiled roots are given against epileptic fits.…”

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confidence: 99%

Histological Studies of Pancreatic Β-Cells of Streptozotocin-Induced Diabetic Wistar Rats Treated With Methanolic Extract of Sphenocentrum Jollyanum

Margaret¹,

Stephen²,

Meshack³

et al. 2013

J Pharm Sci Innov

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Diabetes mellitus is characterized by hyperglycaemia and destruction in the microarchitecture of the β-cells of the pancreatic islets of Langerhans. The search for drugs with low cost, more potential and with less adverse effects is continuous. This study investigated the effects of methanolic extract of Sphenocentrum jollyanum on hyperglycemia and the morphological changes on pancreatic β-cells in streptozotocin-induced diabetic rats and compared the extract efficacy with glibenclamide, a known antidiabetic drug. Twenty four adult Wistar rats randomly divided into four groups were used. Group A was the control, diabetes mellitus was induced in groups B, C and D by a single intraperitoneal injection of streptozotocin (80mg/kg body weight) dissolved in 0.1 M citrate buffer. Group B diabetic rats were untreated while groups C and D received extracts of S. jollyanum (200mg/kg) and glibenclamide (5mg/kg) once daily for two weeks respectively. The result showed a significant fall in blood glucose level with the extract and glibenclamide administration. Histological examination showed recovery of β-cells of the S. jollyanum and glibenclamide treated rats when compared with the diabetic group. There was no significant difference between the effects of the crude extract and the reference drug, glibenclamide.

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confidence: 99%

Histological Studies of Pancreatic Β-Cells of Streptozotocin-Induced Diabetic Wistar Rats Treated With Methanolic Extract of Sphenocentrum Jollyanum

Margaret¹,

Stephen²,

Meshack³

et al. 2013

J Pharm Sci Innov

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“…Studies have associated these compounds with antipyretic activity. According to [30], globulol has antipyretic potential in animal models. The GC-MS results revealed the presence of terpineols which are components of essential oils.…”

Section: Discussionmentioning

confidence: 99%

Antipyretic potential of dichloromethane leaf extract of Eucalyptus globulus (Labill) and Senna didymobotrya (Fresenius) in rats models

Mworia

Kibiti

Ngugi

2019

Heliyon

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IntroductionFever is managed using synthetic drugs such as aspirin, paracetamol among others. Synthetic drugs are associated with many side effects. Herbal medicines form alternative therapy since they possess fewer side effects and are readily available. This study aimed to determine antipyretic potential of DCM extracts of E. globulus and S. didymobotrya in Swiss albino rats.Materials and methodsThe plant leaves samples were obtained from Embu County, Kenya. Dichloromethane solvent was used to extract bioactive constituents from the plant samples. Three grams of DCM leaf extracts of Eucalyptus globulus (Labill) and Senna didymobotrya (Fresenius) samples were obtained and analyzed to determine quantitative phytochemical composition at ICIPE laboratory using GC-MS. Albino rats were used in the antipyretic activity study. Nine groups of five experimental animals were used in each test: Positive control, normal control, negative control and experimental (25, 50, 100, 150, 200 and 250 mg/kg body weight extracts) groups. Pyrexia was induced by injection of turpentine in albino rats intraperitoneally. One hour later, the pyretic animals received the leaf extracts at various dose levels, reference drug (aspirin100 mg/kg body) or the vehicle (DMSO).ResultsResults of antipyretic in vivo bioscreening revealed that E. globulus and S. didymobotrya possess potent antipyretic activity which was comparable to that of the reference drug aspirin. Both extracts exhibited highest antipyretic activity at a dose of 250 mg/kg bw. Results of the GC-MS revealed that these plants possess bio-compounds such as Terpinolene, Alpha-pinene, Borneol, Globulol and Terpineols that are associated with antipyretic activity.ConclusionsIn conclusion, this study revealed that these plants are endowed with bioactive compounds such as terpenoids, and flavonoids that possess antipyretic activity in rats.

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“…Studies have also shown that the metabolic stem bark extract of the plant possesses significant hepatoprotective and antioxidant properties against carbon tetrachloride-induced stress in rats [27]. Petroleum ether and methanol extracts of S. Jollyanum leaves has been reported in previous studies to possess significant in-vitro analgesic and antipyretic properties [28]. This study aims at assessing for analgesic activity of ethanolic leaf extract of Sphenocentrum jollyanum in-vivo in experimental mice.…”

Section: Sphenocentrum Jollyanum Belongs To the Family Menispermaceaementioning

confidence: 96%

In-vivo analgesic activity of ethanol leaf extract of Sphenocentrum Jollyanum in albino mice

Uka¹,

Ndem²,

Iberi³

et al. 2020

IJRP

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Antipyretic and Analgesic Activities of Sphenoceutrum Jollyanum

Cited by 7 publications

References 0 publications

Histological Studies of Pancreatic Β-Cells of Streptozotocin-Induced Diabetic Wistar Rats Treated With Methanolic Extract of Sphenocentrum Jollyanum

Histological Studies of Pancreatic Β-Cells of Streptozotocin-Induced Diabetic Wistar Rats Treated With Methanolic Extract of Sphenocentrum Jollyanum

Antipyretic potential of dichloromethane leaf extract of Eucalyptus globulus (Labill) and Senna didymobotrya (Fresenius) in rats models

In-vivo analgesic activity of ethanol leaf extract of Sphenocentrum Jollyanum in albino mice

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