Antipsychotics Medication Use and its Metabolic Challenges for Autism Spectrum Disorders

García, Georgina

doi:10.7156/v5i3p162

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…These adverse events are also frequent in children, given the sensory difficulties, food selectivity, and rigidity in eating behaviors, which can lead to an increased risk for weight gain and poor nutritional habits [ 68 , 69 , 70 , 71 ]. For this reason, the correct management of pharmacological treatment should try to prevent the onset of side effects, through reviewing and identifying the risk factors, monitoring metabolic markers, and promoting potential modifiers of the course of metabolic syndrome (i.e., lifestyle, polypharmacy) [ 72 ]. For example, patients with a history of weight or diabetes might avoid medications that are known to increase the risk of these side effects, such as risperidone and olanzapine [ 73 , 74 ].…”

Section: Discussionmentioning

confidence: 99%

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

et al. 2020

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The etiopathogenesis of autism spectrum disorder (ASD) remains largely unclear. Among other biological hypotheses, researchers have evidenced an imbalance in the endocannabinoid (eCB) system, which regulates some functions typically impaired in ASD, such as emotional responses and social interaction. Additionally, cannabidiol (CBD), the non-intoxicating component of Cannabis sativa, was recently approved for treatment-resistant epilepsy. Epilepsy represents a common medical condition in people with ASD. Additionally, the two conditions share some neuropathological mechanisms, particularly GABAergic dysfunctions. Hence, it was hypothesized that cannabinoids could be useful in improving ASD symptoms. Our systematic review was conducted according to the PRISMA guidelines and aimed to summarize the literature regarding the use of cannabinoids in ASD. After searching in Web of KnowledgeTM, PsycINFO, and Embase, we included ten studies (eight papers and two abstracts). Four ongoing trials were retrieved in ClinicalTrials.gov. The findings were promising, as cannabinoids appeared to improve some ASD-associated symptoms, such as problem behaviors, sleep problems, and hyperactivity, with limited cardiac and metabolic side effects. Conversely, the knowledge of their effects on ASD core symptoms is scarce. Interestingly, cannabinoids generally allowed to reduce the number of prescribed medications and decreased the frequency of seizures in patients with comorbid epilepsy. Mechanisms of action could be linked to the excitatory/inhibitory imbalance found in people with ASD. However, further trials with better characterization and homogenization of samples, and well-defined outcomes should be implemented.

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Section: Discussionmentioning

confidence: 99%

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

et al. 2020

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show abstract

“…For this reason, the correct management of pharmacological treatment should try to prevent the onset of side effects, through reviewing and identifying the risk factors, monitoring metabolic markers, promoting potential modifiers of the course of metabolic syndrome (i.e. lifestyle, polypharmacy) [68]. For example, patients with a history of weight gain and/or diabetes may avoid medications known to increase the risk of these side effects such as risperidone and olanzapine [69,70].…”

Section: Efficacy and Safety Of Cannabinoids In Asdmentioning

confidence: 99%

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

Fusar-Poli

Cavone

Tinacci

et al. 2020

Preprint

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The etiopathogenesis of autism spectrum disorder (ASD) remains largely unclear. Among other biological hypotheses, researchers have evidenced an imbalance in the endocannabinoid (eCB) system, which regulates some functions typically impaired in ASD, such as emotional responses and social interaction. Also, cannabidiol (CBD), the non-intoxicating component of Cannabis sativa, has been recently approved for treatment-resistant epilepsy. Seizures represent frequent medical comorbidities of ASD and could be responsible for the onset or worsening of behavioral problems. Thus, it has been hypothesized that cannabinoids could be useful in improving some ASD symptoms. Our systematic review was conducted according to the PRISMA guidelines and aimed to summarize the literature regarding the use of cannabinoids in ASD. After searching in Web of KnowledgeTM, PsycINFO, and Embase, we included ten studies (eight papers and two abstracts). Four ongoing trials were retrieved in ClinicalTrials.gov. Findings are promising, as cannabinoids appeared to improve problem behaviors, sleep, hyperactivity, and communication deficits, with limited cardiac and metabolic side effects. Interestingly, they generally allowed to reduce the number of prescribed medications and decreased the frequency of seizures in epileptic patients. Mechanisms of action could be linked to the excitatory/inhibitory imbalance found in people with ASD. However, further trials need to be implemented with better characterization and homogenization of samples, and well-defined outcomes.

show abstract

Antipsychotics Medication Use and its Metabolic Challenges for Autism Spectrum Disorders

Cited by 2 publications

References 30 publications

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

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