Antipsychotics During Pregnancy

Littrell, Kimberley H.; Johnson, Craig; Peabody, Carol D.; Hilligoss, Nicole M.

doi:10.1176/appi.ajp.157.8.1342

Cited by 43 publications

(31 citation statements)

References 4 publications

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“…It has been reported that the most commonly prescribed atypical antipsychotic in pregnancy is olanzapine [45], which has been described to be successful in a number of case studies [51][52][53]. There has been no general increase in malformations associated with this medication, except for a concern regarding a potential increase in the risk of neural tube defects [39].…”

Section: The Effects Of Antipsychotic Medications On Fetal Morphologymentioning

confidence: 99%

“…Clozapine and quetiapine have also been taken in pregnancy, and > 200 cases on each have been reported [53]. Although some cases of congenital defects have been identified in these reports, no specific pattern of malformation has been shown and the rate has not exceeded the baseline malformation rate of the general population [34,39,54].…”

Section: The Effects Of Antipsychotic Medications On Fetal Morphologymentioning

confidence: 99%

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Antipsychotic use in pregnancy

Kulkarni¹,

Storch

Baraniuk

et al. 2015

Expert Opinion on Pharmacotherapy

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Given the potential harm of not treating severe psychiatric illnesses during pregnancy, careful administration of antipsychotics is recommended for pregnant women who suffer from severe mental disorders. The most frequently used antipsychotics in pregnancy are olanzapine, risperidone and quetiapine, and do not appear to cause consistent, congenital harm to the fetus. No specific patterns of fetal limb or organ malformation related to these drugs have been reported. There is some evidence suggesting an association between antipsychotic use in pregnancy and the development of gestational diabetes. Also there appears to be an association between antipsychotic medication use in pregnancy and increased neonatal respiratory distress and withdrawal symptoms. Further studies are needed for clinicians to balance good maternal mental health, healthy pregnancies and good infant health outcomes.

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Section: The Effects Of Antipsychotic Medications On Fetal Morphologymentioning

confidence: 99%

Section: The Effects Of Antipsychotic Medications On Fetal Morphologymentioning

confidence: 99%

Antipsychotic use in pregnancy

Kulkarni¹,

Storch

Baraniuk

et al. 2015

Expert Opinion on Pharmacotherapy

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“…Only a few case reports dealing with olanzapine treatment during pregnancy are present in the literature. One case ended with a therapeutic abortion performed at the patient's request, and no fetal abnormalities were observed (Dickson and Dawson, 1998), whereas in two others no adverse effects were found in the newborns (Kirchheiner et al, 2000;Littrell et al, 2000). Finally, a study in which 23 pregnancies were followed suggested a favorable risk-to-benefit ratio for the fetus and infant following olanzapine exposure, since spontaneous abortion, prematurity, or major malformation in offspring did not occur (Goldstein et al, 2000).…”

Section: A Antipsychotic Drugsmentioning

confidence: 99%

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

2004

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“…2004). Exposure to antipsychotic medication during pregnancy is associated with potential obstetric, teratogenic, neurobehavioural and neonatal risks of toxicity (Littrell et al. 2000, McKenna et al.…”

Section: Introductionmentioning

confidence: 99%

Antipsychotics in pregnancy

McCauley-Elsom

Gurvich²,

Elsom

et al. 2010

Journal of Psychiatric and Mental Health Nursing

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Women who are pregnant and who have a history of psychosis are commonly managed with antipsychotic medications. The evidence regarding the use of antipsychotics in pregnancy has been insufficient to provide adequate support for this practice and is a concern for clinicians and women alike. This review presents literature surrounding the use of antipsychotic medications in pregnancy, providing an overview of the historical and contemporary perspectives which influence clinicians prescribing practices. Data were sourced from Medline, CINAHL, PsycINFo, using the terms antipsychotics with pregnancy and psychosis or schizophrenia. This was expanded to include the most common atypical antipsychotics: olanzapine, risperidone, clozapine, quetiapine, ziprasidone and aripiprazole. Literature was found reporting the use of antipsychotic medications in pregnancy since the introduction of antipsychotics in the 1950s, comprising mainly of authors' reviews of the literature, case studies, retrospective reports, drug company registries and more recently a prospective comparative study. This review identifies that the literature provides no clear answer for clinicians as to the risk associated with the use of antipsychotics in pregnancy. To this effect, recently in Australia, the National Register of Antipsychotic Medications in Pregnancy was established to prospectively collect information regarding outcomes for mother and baby, when antipsychotic medications have been used during pregnancy.

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Antipsychotics During Pregnancy

Cited by 43 publications

References 4 publications

Antipsychotic use in pregnancy

Antipsychotic use in pregnancy

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

Antipsychotics in pregnancy

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