Antipsychotics and Sexual Functioning Questionnaire©

Knegtering, Henderikus; Castelein, Stynke; Boer, Marrit K. de

doi:10.1037/t27043-000

Cited by 6 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reports available suggest that patients using these antipsychotics may have comparatively lower rates of sexual dysfunction. 1,[5][6][7][41][42][43]74 Besides having affinity for the dopamine receptor, antipsychotics interact with many neurotransmitter systems in the brain and other parts of the body. Affinity for the serotonergic, noradrenergic, histaminic, and cholinergic/muscarinic neurotransmitter systems differs among the various groups of antipsychotics.…”

Section: Pharmacological Mechanisms In Antipsychotic-induced Sexual Dmentioning

confidence: 99%

The Facts About Sexual (Dys)function in Schizophrenia: An Overview of Clinically Relevant Findings

Boer

Castelein

Wiersma

et al. 2015

Schizophrenia Bulletin

138

115

View full text Add to dashboard Cite

A limited number of studies have evaluated sexual functioning in patients with schizophrenia. Most patients show an interest in sex that differs little from the general population. By contrast, psychiatric symptoms, institutionalization, and psychotropic medication contribute to frequently occurring impairments in sexual functioning. Women with schizophrenia have a better social outcome, longer lasting (sexual) relationships, and more offspring than men with schizophrenia. Still, in both sexes social and interpersonal impairments limit the development of stable sexual relationships. Although patients consider sexual problems to be highly relevant, patients and clinicians not easily discuss these spontaneously, leading to an underestimation of their prevalence and contributing to decreased adherence to treatment. Studies using structured interviews or questionnaires result in many more patients reporting sexual dysfunctions. Although sexual functioning can be impaired by different factors, the use of antipsychotic medication seems to be an important factor. A comparison of different antipsychotics showed high frequencies of sexual dysfunction for risperidone and classical antipsychotics, and lower frequencies for clozapine, olanzapine, quetiapine, and aripiprazole. Postsynaptic dopamine antagonism, prolactin elevation, and α 1 -receptor blockade may be the most relevant factors in the pathogenesis of antipsychotic-induced sexual dysfunction. Psychosocial strategies to treat antipsychotic-induced sexual dysfunction include psychoeducation and relationship counseling. Pharmacological strategies include lowering the dose or switching to a prolactin sparing antipsychotic. Also, the addition of a dopamine agonist, aripiprazole, or a phosphodiesterase-5 inhibitor has shown some promising results, but evidence is currently scarce.

show abstract

Section: Pharmacological Mechanisms In Antipsychotic-induced Sexual Dmentioning

confidence: 99%

The Facts About Sexual (Dys)function in Schizophrenia: An Overview of Clinically Relevant Findings

Boer

Castelein

Wiersma

et al. 2015

Schizophrenia Bulletin

138

115

View full text Add to dashboard Cite

show abstract

“…Overall, risperidone [ 66 , 67 ] and other classical APS [ 62 , 68 , 69 , 70 , 71 , 72 , 73 ] have a higher incidence of TESD when compared with other atypical neuroleptics such as clozapine [ 73 , 74 , 75 ], olanzapine [ 62 , 68 , 71 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ], quetiapine [ 62 , 66 , 71 , 72 , 83 , 84 , 85 , 86 ], or aripiprazole [ 87 , 88 , 89 ]. When analyzing TESD by each sexual dimension comparing different APS, this becomes even more obvious, given how SD rates are so different for each antipsychotic [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…With one exception [ 72 ], most of the studies agree that, when dosing below 400 mg/day, sexual function is mostly preserved [ 62 , 82 , 84 ], but when dosing at around 500 mg/day and above, SD may appear with a severity in proportion to dosage [ 66 , 120 ], although usually less so than the previously mentioned antipsychotics [ 53 , 121 ]. Quetiapine has also been described as particularly helpful in preserving sexual arousal [ 52 , 66 , 72 ].…”

Section: Resultsmentioning

confidence: 99%

“…These data are gathered from either clinical trials or post-commercialization observations, which mainly aim to measure clinical efficacy, not SD incidence. However, when specific interviews are used to measure SD, the incidence rates are consistently higher, at 40–50% [ 52 , 53 ]. Old samples of chronic schizophrenic patients in outpatient monitoring suggest up to 60% of SD in this population after years of treatment [ 54 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Management Strategies for Antipsychotic-Related Sexual Dysfunction: A Clinical Approach

Montejo

Alarcón

Prieto

et al. 2021

JCM

View full text Add to dashboard Cite

Antipsychotic medication can be often associated with sexual dysfunction (SD). Given its intimate nature, treatment emergent sexual dysfunction (TESD) remains underestimated in clinical practice. However, psychotic patients consider sexual issues as important as first rank psychotic symptoms, and their disenchantment with TESD can lead to important patient distress and treatment drop-out. In this paper, we detail some management strategies for TESD from a clinical perspective, ranging from prevention (carefully choosing an antipsychotic with a low rate of TESD) to possible pharmacological interventions aimed at improving patients’ tolerability when TESD is present. The suggested recommendations include the following: prescribing either aripiprazole or another dopaminergic agonist as a first option antipsychotic or switching to it whenever possible. Whenever this is not possible, adjunctive treatment with aripiprazole seems to also be beneficial for reducing TESD. Some antipsychotics, like olanzapine, quetiapine, or ziprasidone, have less impact on sexual function than others, so they are an optimal second choice. Finally, a variety of useful strategies (such as the addition of sildenafil) are also described where the previous ones cannot be applied, although they may not yield as optimal results.

show abstract

“…In order to ensure consistency in the structure of the ASFQ, each item is scored as 0 (unknown), 1 (significantly decreased), 2 (mildly decreased), 3 (unchanged), 4 (mildly increased), and finally, 5 (significantly increased). 19 , 20 …”

Section: Methodsmentioning

confidence: 99%

Translation and Validation of the Greek Version of the Antipsychotics and Sexual Functioning Questionnaire (ASFQ)

et al. 2021

View full text Add to dashboard Cite

Introduction: Sexual dysfunction in patients with psychoses may be associated with the psychiatric illness itself (negative symptoms, such as apathy, and avolition), comorbid somatic health, psychosocial factors (stigmatization, discrimination), and the use of psychotropic drugs. In Greece, research into the study of antipsychoticinduced sexual dysfunction is not sufficient. Aim: This study was conducted to translate and validate the Greek version of the Antipsychotics and Sexual Functioning Questionnaire (ASFQ) in a sample of patients receiving antipsychotic treatment. Methods: A "forward-backward translation" method was applied. A pilot study was conducted with 15 outpatients with schizophrenia and bipolar disorder under antipsychotics treatment. Patients also completed the "Subjects' Response to Antipsychotics (SRA)" questionnaire in order to assess the validity of the ASFQ. The ASFQ and the SRA questionnaire were completed twice within 2 weeks. Main outcome measures: Reliability (internal consistency and test-retest) and validity were assessed. Results: The Greek translation of ASFQ was reliable, with excellent internal consistency (Cronbach's a = 0.90 for men and 0.95 for women in both measurements). In addition, the Spearman correlation coefficient was 1 (P< .001) in all Likert-type questions in both assessments. Finally, Spearman correlation coefficients between ASFQ and SRA were moderately positive to strongly positive (between 0.25 and 1) in both assessments, demonstrating moderate to high validity. Conclusions: The Greek version of the ASFQ has proved to be a reliable and valid clinical instrument, hence it can be used in further studies in the Greek population. M Angelaki, P Galanis, A Igoumenou, et al. Translation and Validation of the Greek Version of the Antipsychotics and Sexual Functioning Questionnaire (ASFQ). J Sex Med 2021;XX:XXX−XXX.

show abstract

Antipsychotics and Sexual Functioning Questionnaire©

Cited by 6 publications

References 0 publications

The Facts About Sexual (Dys)function in Schizophrenia: An Overview of Clinically Relevant Findings

The Facts About Sexual (Dys)function in Schizophrenia: An Overview of Clinically Relevant Findings

Management Strategies for Antipsychotic-Related Sexual Dysfunction: A Clinical Approach

Translation and Validation of the Greek Version of the Antipsychotics and Sexual Functioning Questionnaire (ASFQ)

Contact Info

Product

Resources

About