Antipsychotic Treatment Duration in Children and Adolescents: A Register-Based Nationwide Study

Varimo, Eveliina; Aronen, Eeva T.; Mogk, Hannu; Rättö, Hanna; Saastamoinen, Leena

doi:10.1089/cap.2020.0095

Cited by 9 publications

(4 citation statements)

References 38 publications

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“…Psychotropic drugs have side effects that may affect many patients, but considering that the pediatric population is more susceptible to side effects (12,13). In our study, the researchers examined how side effects impact medication adherence in pediatric patients and found that patients who experienced side effects (28.13%) had lower adherence to medication (p<0.05) and were more likely to have concerns about their medication and negative attitudes towards treatment (p<0.05).…”

Section: Discussionmentioning

confidence: 93%

“…Additionally, the signi cant effects of antidepressant selection on medication discontinuation was detected not in the rst month but in the second month of the treatment (19). In another study, starting treatment with quetiapine was found to be associated with early treatment discontinuation (12). The analysis revealed that there was no signi cant relationship between psychotropic drug groups and adherence.…”

Section: Discussionmentioning

confidence: 96%

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Insights Into Adherence and Attitudes toward Medication In Child And Adolescent Psychiatry: The Influence Of Patient And Medication-Related Factors

Bayraktar,

Yalçın,

Nalbant

et al. 2024

Preprint

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This study aimed to investigate the impact of perception on adherence and determine the influence of patient- and medication-related factors on both adherence and attitudes toward medication in adolescents with psychiatric disorders receiving medication. The Pediatric Medication Adherence Scale (PMAS)- 9 questions and the Pediatric Attitude toward Medication Scale (PAMS)- 18 questions, two reliable self-report scales designed for this population, were used to assess negative adherence behaviors and patients' perceptions of medication. Data were collected from a sample of adolescents (12-18 years) undergoing psychotropics for 2 months. Statistical analysis was conducted to examine correlations between adherence, attitudes, and patient characteristics. The scales were administered to 288 patients (67% female) and significant correlations were found between anxiety scores and attitudes toward medication (p<0.05). Patients receiving monotherapy showed lower anxiety scores and more positive attitudes (p<0.05). Side effects were associated with reduced adherence and negative attitudes. Patients diagnosed with an eating disorder had more negative attitudes, while those using antidepressant-antipsychotic combinations had more negative attitudes compared to stimulants. This study highlights the importance of considering influential factors in medication adherence and attitudes in clinical practice for adolescents with psychiatric disorders. Addressing anxiety perception, managing side effects, and evaluating polypharmacy were found important for pharmacotherapy optimization.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Insights Into Adherence and Attitudes toward Medication In Child And Adolescent Psychiatry: The Influence Of Patient And Medication-Related Factors

Bayraktar,

Yalçın,

Nalbant

et al. 2024

Preprint

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show abstract

“…In addition, side effects were mentioned as additional disadvantages of treatment and were also described as potential barriers to medication intake and adherence. Although it is well known that psychotropic medications have common side effects, it is often overlooked that young people are more susceptible to them than adults [ 22 , 23 ]. The systematic review by McMillan et al [ 8 ] reaffirms our findings, documenting 18 studies describing experiences with side effects and how, in some cases, this can lead to medication aversion.…”

Section: Discussionmentioning

confidence: 99%

Perceptions and Experiences of Adolescents with Mental Disorders and Their Parents about Psychotropic Medications in Turkey: A Qualitative Study

Dіkeç

Kardelen

González

et al. 2022

IJERPH

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This descriptive phenomenological study aimed to evaluate the perception and experiences of adolescents with mental disorders and their parents about the use of and adherence to psychotropic medications. A total of 12 semi-structured interviews with adolescents between the ages of 12 to 18 who were attending an outpatient psychiatric clinic for children and adolescents and 12 interviews with parents were conducted between October 2021 and January 2022 in Manisa, Turkey. Colaizzi’s phenomenological interpretation method was used for the analysis of the participants’ statements. Our study highlights the main positive effects of psychotropic medication and barriers to medication intake and adherence. Positive effects included symptom management and health improvement. Barriers varied from those directly linked to medication effects (e.g., negative side effects or lack of perceived effect) to personal barriers (e.g., forgetting to take medication or feelings of not being oneself due to medication intake) and societal barriers. In general, the barriers were reflected in concerns related to long-term consequences, such as medication dependence, and in concerns about diminished life prospects. Possible recommendations to improve the use of and adherence to psychotropic medication among adolescents include educating adolescents and parents not only about treatment options but also about mental disorders.

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“…Although risperidone is only licensed for the treatment of persistent aggression in conduct disorder in children and adolescents with subaverage intellectual functioning for a period of up to 6 weeks, the typical treatment duration in clinical practice is much longer. Finnish Prescription Registry data of all subjects aged 1-17 years who had started a second-generation antipsychotic drug (risperidone, quetiapine, aripiprazole, or olanzapine) between January 2008 and December 2016 revealed a mean and median treatment duration of 509 and 317 days, respectively [9]. The duration was shorter in girls than in boys (p < 0.001).…”

mentioning

confidence: 98%

First do no harm: use off-label antipsychotic medication in children and adolescents with great caution

Hoekstra

Dietrich

2022

Eur Child Adolesc Psychiatry

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Antipsychotic Treatment Duration in Children and Adolescents: A Register-Based Nationwide Study

Cited by 9 publications

References 38 publications

Insights Into Adherence and Attitudes toward Medication In Child And Adolescent Psychiatry: The Influence Of Patient And Medication-Related Factors

Insights Into Adherence and Attitudes toward Medication In Child And Adolescent Psychiatry: The Influence Of Patient And Medication-Related Factors

Perceptions and Experiences of Adolescents with Mental Disorders and Their Parents about Psychotropic Medications in Turkey: A Qualitative Study

First do no harm: use off-label antipsychotic medication in children and adolescents with great caution

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