Antipsychotic treatment and changes in health related quality of life in patients with schizophrenia using EQ-5D

Badia, X; Casado, Alfonso; Sacristán, J A; Jc, Gómez; Gregor, KJ

doi:10.1016/s0920-9964(00)91061-2

Cited by 5 publications

(4 citation statements)

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“…The QoL score was lower in the group with possible PTSD (mean score 39.6 mm), than what has been reported for many other diseases. One group of patients with small cell lung cancer scored on average 58 mm (20), patients with rheumatoid arthritis scored 56 mm (21), multiple sclerosis 49 mm (22), and patients with schizophrenia scored on average 49 mm (23). Only patients with late stage amyotrophic lateral sclerosis (mean score 37 mm) (24) scored lower on self-rated QoL than respondents did in our study.…”

Section: Discussioncontrasting

confidence: 50%

Post-traumatic stress associated with low self-rated well-being in primary care attenders

Thulesius

Alveblom

Håkansson

2004

Nordic Journal of Psychiatry

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In this study, we assessed the prevalence of self-rated post-traumatic stress in relation to reported trauma in an unselected primary care population. A total of 1,113 out of 1,378 consecutive attenders (response rate 81%) to 10 health centres completed the self-report instruments Impact of Event Scale (IES), and Post Traumatic Symptom Scale (PTSS-10). A horizontal visual analogue scale (VAS; 0-100 mm) resembling the EuroQoL (quality of life) health barometer was used for evaluating well-being. Trauma was reported by 325 attenders (29.2%) when applying DSM-IV trauma criteria. Prevalence of possible post-traumatic stress disorder (PTSD) was 6.5% (n=72) using cut-off scores of >35 for IES and >5 for PTSS-10. The two most common traumas in the PTSD group were accidents (2.0%, n=22), followed by cancer (1.3%, n=15). When excluding diseases and unspecified death as trauma, the rate of possible PTSD was 3.5% (n=39). Mean VAS-QoL score was 39.6 mm in the PTSD group (n=72), and 64.7 mm in the non-PTSD group with a reported trauma (n=253). In a multiple logistic regression analysis low self-rated well-being showed the strongest association with possible PTSD, followed by sexual assault, female gender, immigrant status and less than 2 years since trauma.

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Section: Discussioncontrasting

confidence: 50%

Post-traumatic stress associated with low self-rated well-being in primary care attenders

Thulesius

Alveblom

Håkansson

2004

Nordic Journal of Psychiatry

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“…This notion is supported by the fact that a simple non-weighted sum-score of dimensions, more adequately signifies the apparent changes. Also in a study of Badia et al [29] on antipsychotic treatment and changes in QoL in schizophrenic patients, these notions are more or less supported. In their study the domains 'daily activities' and 'anxiety/depression' improved in a rather similar way (from an average of 82 and 78% of patients with problems in both domains to 55 and 46% respectively).…”

Section: Discussionmentioning

confidence: 97%

Changes in quality of life in chronic psychiatric patients: A comparison between EuroQol (EQ-5D) and WHOQoL

et al. 2005

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It has often been postulated that simple, short questionnaires are unable to reflect complex changes in well-being of individuals with chronic psychiatric disorders. To investigate these assumptions we included two recently developed instruments to measure quality of life (the WHOQoL-Bref and the EuroQoL EQ-5D) in a randomised control trial (RCT) in which two treatment conditions were compared. Aims of the study were to assess the sensitivity and validity of these quality of life (QoL)-instruments, to establish their relationship and to examine the predictors of changes in QoL. Subjective changes in QoL were measured on three assessments waves in a period of 18 months and compared to objective changes in psychopathology and social functioning in a sample of 76 chronic schizophrenic patients who participated in the RCT. Results indicated that both WHOQoL-Bref and EuroQoL EQ-5D are capable of detecting changes in QoL over time in physical and psychological well-being. The instruments partly measure the same aspects of QoL, indicated by 50% common variance on total scores. Reduction of positive psychotic symptoms appeared to be the most important factor in improving QoL. The weighted TTO-score of EuroQoL-5D, which is often used as an index in economic evaluations of health care, did however not correspond with these changes, which indicates that it is less sensitive to changes in social and psychological well-being. It's use as the core measure in (economic) health evaluation in the field of psychiatry therefore seems less appropriate.

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“…Previous published results from the EFESO study have shown that olanzapine-treated patients have achieved superior outcomes compared to patients treated with risperidone or haloperidol [31,33,34]. Statistically significant findings favouring olanzapine-treated patients compared to risperidone- and/or haloperidol-treated patients have included the proportion of patients who experienced at least one adverse event, the percentage of patients who developed EPS, and the proportion of responders at month six (olanzapine compared to risperidone).…”

Section: Discussionmentioning

confidence: 99%

Subjective response to antipsychotic treatment and compliance in schizophrenia. A naturalistic study comparing olanzapine, risperidone and haloperidol (EFESO Study)

et al. 2001

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Antipsychotic treatment and changes in health related quality of life in patients with schizophrenia using EQ-5D

Cited by 5 publications

References 0 publications

Post-traumatic stress associated with low self-rated well-being in primary care attenders

Post-traumatic stress associated with low self-rated well-being in primary care attenders

Changes in quality of life in chronic psychiatric patients: A comparison between EuroQol (EQ-5D) and WHOQoL

Subjective response to antipsychotic treatment and compliance in schizophrenia. A naturalistic study comparing olanzapine, risperidone and haloperidol (EFESO Study)

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