“…In comparison to amyloid reduction, the effect of BZDs on hippocampal volume has been less studied. One clinical study found an independent positive association of BZD use and hippocampal volume in a population of middle-aged psychiatric patients 35 . Preclinical studies show inconsistent findings on the effect of BZDs on BDNF in the hippocampus of mice, such that acute but not repeated BZD treatment decrease BDNF concentration 36 .…”