Antipsoriatic effect of fumaric acid derivatives

Altmeyer, Peter; Mattlies, Ulrich; Pawlak, F; Hoffmann, Klaus; Frosch, Peter J.; Ruppert, Peter; Wassilew, S. W.; Horn, Thomas; Kreysel, H. W.; Lutz, G.; Barth, J; Rietzschel, I; Joshi, Rajendra K.

doi:10.1016/s0190-9622(94)70121-0

Cited by 272 publications

(68 citation statements)

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“…Together with former studies our results indicate that fumarates possess a high antipsoriatic clinical efficacy [1, 3, 4, 6, 10, 11, 12]. The group of patients examined for this study also reported positive subjective effects of FAE therapy.…”

Section: Discussionsupporting

confidence: 85%

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Fumaric Acid Esters Suppress Peripheral CD4- and CD8-Positive Lymphocytes in Psoriasis

Höxtermann

Nüchel

Altmeyer³

1998

Dermatology

102

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Background: For severe forms of psoriasis vulgaris, the antipsoriatic fumaric acid esters (FAE) therapy has recently gained increasing acceptance and importance. Until today, there is little knowledge about the mode of action of FAE. However, some evidence exists indicating immunosuppressive effects. Objective: The aim of this study was to examine the systemic, particularly the immunological changes in patients suffering from psoriasis treated with FAE over a long period of time, since we expect to see pharmacological effects of FAE at this point. Methods: This study is based on continuously recorded clinical data and laboratory parameters of 10 patients, who were treated over a period of 12 months with FAE. A quantitative analysis of lymphocytes and their subtypes was carried out by means of flowcytometric methods. Results: 3 months after starting treatment with FAE, a clinical effect with a remission index >95% was achieved in all 10 patients examined. This remained constant until the end of this study. Focusing on leukopenia, and particulary on lymphopenia as important parameters, these effects were found in all patients. The lymphocyte subpopulations data demonstrated extensive proportionate reductions. Within the T cell fraction a stronger suppression of CD8⁺ lymphocytes was observed. Conclusion: Our investigations of systemic effects of fumaric acid esters demonstrate the suppressive character of this medication. Effects of cell count reduction in leukocyte and lymphocyte numbers over the entire period of 12 months could be observed. The lymphocytic cell count number is obviously linked to the clinical effect.

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Section: Discussionsupporting

confidence: 85%

“…Evidence of the high efficacy of FAE treatment has already been reported by several, partly placebo-controlled double-blind studies [1, 2, 3, 4, 5, 6]. Until today, only hypotheses exist on the mode of operation of this medication.…”

Section: Introductionmentioning

confidence: 99%

Fumaric Acid Esters Suppress Peripheral CD4- and CD8-Positive Lymphocytes in Psoriasis

Höxtermann

Nüchel

Altmeyer³

1998

Dermatology

102

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“…As the enteral absorption of fumaric acid itself is very low, esters of fumaric acid are used for therapy. FAE have immunomodulatory properties with positive therapeutic effects in patients with psoriasis vulgaris [4,5,6,7]. As mode of action, among others, an inhibition of lymphocyte proliferation and cytokine secretion is discussed.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Granuloma Annulare – Treatment with Fumaric Acid Esters

Eberlein-König¹,

Mempel²,

Stahlecker

et al. 2005

Dermatology

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Background:The therapy of disseminated granuloma annulare has often limited success. Treatment of granuloma annulare with fumaric acid esters (FAE) has recently been reported to be effective in 2 patients. Objectives: To assess the efficacy of a systemic therapy with FAE in consecutive patients with disseminated granuloma annulare. Methods:Eight patients with disseminated granuloma annulare were treated with FAE in tablet form according to the standard therapy regimen used in psoriasis. The colour and the elevation of the skin lesions were assessed by a visual analogue scale before and after therapy. Results:Systemic therapy with FAE induced a significant clinical improvement in elevation and colour of skin lesions, with remission in 3 and partial remission in 4 patients. One patient remained unchanged. Side-effects associated with the therapy were seen in 6 patients. Conclusions: Systemic therapy with FAE can be effective in patients suffering from disseminated forms of granuloma annulare, but side-effects of FAE have to be taken into consideration.

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“…29 Citric acid (known for its antioxidant activity) is also a crystal thickener in bones 30 while fumaric acid is effective against psoriasis and inflammation, and can be used potentially as a neuro and chemoprotector. 31,32 Due to its properties, oxalic acid constitutes part of pharmaceutical preparations and is used for desloughing wounds and ulcers, 33 while quinic acid is a stronger antioxidant. 34 Analysing the results obtained for the phenolic acids detected in the studied samples (Table 2), we can conclude that the Portuguese sample showed a higher content of these compounds (0.59 mg/100 g dw) compared with the Serbian samples (0.13 mg/100 g dw).…”

Section: Chemical Compositionmentioning

confidence: 99%

Can Suillus granulatus (L.) Roussel be classified as a functional food?

et al. 2014

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The present work outlines a detailed chemical characterization of Suillus granulatus species, besides the antioxidant and antimicrobial properties of their methanolic extracts. The study was carried out with samples drawn from Portugal and Serbia in order to prove that though mushrooms are strongly influenced by the environment in which they develop, they have a specific chemical profile that can be typical of their genus/species. The studied species proved to be healthy foods, low in fat and rich in protein and carbohydrates, with mannitol and trehalose being the main free sugars detected. They also proved to be a source of organic and phenolic acids, as well as mono-and polyunsaturated fatty acids and tocopherols. The Serbian samples revealed higher antioxidant and antimicrobial potential. Accordingly, we find that the S. granulatus species is likely to be considered a functional food, since it is a source of nutraceutical and biologically active compounds.

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Antipsoriatic effect of fumaric acid derivatives

Cited by 272 publications

References 5 publications

Fumaric Acid Esters Suppress Peripheral CD4- and CD8-Positive Lymphocytes in Psoriasis

Fumaric Acid Esters Suppress Peripheral CD4- and CD8-Positive Lymphocytes in Psoriasis

Disseminated Granuloma Annulare – Treatment with Fumaric Acid Esters

Can Suillus granulatus (L.) Roussel be classified as a functional food?

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