Antipsoriatic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers in a novel in vivo screening model

Immune response of a human body to the uncertain factors leads to the accelerated inflammatory proliferation of the ailing cells of the skin known as Psoriasis. Although the condition found described many decades ago, the etiology and treatment look under-researched. In Ayurveda, many herbs have proven efficacy in psoriasis, but the multifaceted etiology of the disease needs a multimodal treatment approach. We report about Ayurveda treatment in a 68-year-old female patient with plaque psoriasis presented with erythematous plaques on the anterior surface of the legs, right forehand, and neck region. The Auspitz sign and Koebner phenomenon were positive. The treatment protocol was adopted as per Ayurvedic samprapti (pathophysiology) and the patient cured completely without reporting any adverse events after the one year of treatment. No recurrence observed even after one year of the halted treatment. The importance of a wholesome diet as a health promoter is also revalidated. Photographic documentation was recorded with the proper consent of the patient during successive treatment and regular follow-ups. Altogether, multimodal Ayurveda treatment led to speedy and substantial recovery from a chronic case of psoriasis.

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“…Dhataki pushpa (flowers of Woodfordia fruticosa Kurz.) is useful in inflammation and skin diseases [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Potential implications of Ayurveda in Psoriasis: A clinical case study

Nille

Chaudhary

2021

Journal of Ayurveda and Integrative Medicine

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“…Redness, erythema, and scales were scored independently on a scale from 0 to 4: 0, none; 1, slight; 2, moderate; 3, marked; and 4, very marked. The cumulative score (sum of redness, erythema, and scaling) served as a measure of the psoriasis severity index (PSI) (scale 0-12) 24 . After induced psoriasis from the 8 th day onwards extract treatment were started once daily, 5 times in a week, for 21 days.…”

Section: Grouping Of Animals and Experimental Methodsmentioning

confidence: 99%

Phytochemical screening, metallic ion content and from its impact on Anti psoriasis activity of Calendula officinalis and Phlebodium decumanum aqueous leaf extracts in animal experiment model

Das¹,

Deb²,

Karanth³

2018

tjps

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ObjectiveThe aim of this study is to evaluate the influence of metal ions present in soil as well as in the leaves samples of Calendula officinalis and Phlebodium decumanum for the treatment of psoriasis. MethodsLooking at the objective, soils and leaves samples were estimated for metal ions by atomic absorption spectrophotometer to determine the influence in anti-psoriatic activity. Thereafter Imiquimod-induced dermatitis lesions were created in grouped mouse. Two plant extracts (aqueous) separately as well as in combinations and standard Retino-A (0.05%) were used.Psoriasis severity index (PSI) was evaluated by phenotypic (redness, erythema, and scales) and histological features (epidermal thickness). Further content of phytochemicals in terms of extract was correlated with the effect of psoriasis activity. Results:We observed redness, erythema and scales and the histological features and found a progressive reduction (P < 0.05) in the severity of psoriatic lesions (redness, erythema, and scales) from day 7 to 21 st day and decreased epidermal thickness in animals treated with combined extracts at the dose of 200 mg/kg b.w. Furthermore plant samples procured from Nandi Hill's, Bangalore, showed better uptake of metals with respect to Fe (2.05 mg/kg), Cu (0.78 mg/kg) and Zn (1.12 mg/kg) which showed positive impact on procurement of maximum amount of extracts that further correlated with the activity, indicated significant reduction of psoriatic lesions. ConclusionResults revealed that significant dose dependent antipsoriasis activity of combined aqueous extracts of Calendula officinalis and Phlebodium decumanum as well as metal ions are also had impact on the procurement of extracts and said activity.

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“…Psoriasis was induced in animals as mentioned above. After induction, animals were divided into four groups comprising of 6 animals (n = 6) in each group as follows: Severity Index (SI) [13] Animals were evaluated by the severity index of psoriatic lesions every fourth day. A visual scoring system was developed based on severity.…”

Section: Induction Of Psoriasismentioning

confidence: 99%

SettingsTOPICAL APPLICATION OF TERMINALIA CHEBULA CREAM INHIBITS ULTRAVIOLET-B-INDUCED PSORIASIS IN RATS

Pai¹,

Rao²,

Rajendra

et al. 2020

J App Pharm Sci Res

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Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream inultraviolet –B-induced psoriasis in rats.Materials and Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol,methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content wasdetermined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of theoptimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm withUV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined.Results: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and Total triterpenoid (mg ursolic acid/ g) contentwas found to be significant for water extract.The reducing ability of water extract was always higher than methanol extract at all theconcentrations.Conclusion: We concluded that cream containing 0.1% water extract of Terminalia chebula seeds possess antioxidant activity along withpotent antipsoriatic activity. Further, the application of Terminalia chebula cream resulted in decrease in relative epidermal thickness of animalskin as well as other histopathological features. The present investigation aims at the development of potent phytomedicine for treatment ofpsoriasis from the Terminalia chebula plant.

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Antipsoriatic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers in a novel in vivo screening model

Cited by 13 publications

References 22 publications

Potential implications of Ayurveda in Psoriasis: A clinical case study

Potential implications of Ayurveda in Psoriasis: A clinical case study

Phytochemical screening, metallic ion content and from its impact on Anti psoriasis activity of Calendula officinalis and Phlebodium decumanum aqueous leaf extracts in animal experiment model

SettingsTOPICAL APPLICATION OF TERMINALIA CHEBULA CREAM INHIBITS ULTRAVIOLET-B-INDUCED PSORIASIS IN RATS

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