Antipseudomonal property of honey and aminoglycosides

Abstract

Abstract:Pseudomonas aeruginosa has an ability to rapidly develop resistance to most antimicrobial compounds, and to check this ability. The isolates were collected from different pathological human sources and tested for their sensitivity to aminoglycoside antibiotic and to honey, a natural product that is generating renewed interest for its therapeutic application using Kirby Bauer disc diffusion technique. Aminoglycoside antibiotic which is normally active against gram-negative bacteria was used alongside honey. The 29 isolates of P. aeruginosa showed 100% sensitivity to honey tested in their undiluted form. This was not the case with gentamicin (10µg) and amikacin (30 µg), both of which varied in their antipseudomonal activity, like even 1:2 aqueous dilution of honey appreciably inhibited pseudomonal isolates than either of the two aminoglycoside antibiotic. Honey is therefore suggested as an effective natural product in overcoming the widespread antibiotic resistance of P. aeruginosa.