Antiprotozoal, Schistosomicidal, and Antimicrobial Activities of the Essential Oil from the Leaves of <i>Baccharis dracunculifolia</i>

Parreira, Natállia A.; Magalhães, Lizandra G.; Morais, Denis R.; Caixeta, Soraya C.; Sousa, João Paulo Barreto de; Bastos, Jairo Kenupp; Cunha, Wilson Roberto; Silva, Márcio Luís Andrade e; Nanayakkara, N. P. Dhammika; Rodrigues, Vanderlei; Filho, Ademar A. Da Silva

doi:10.1002/cbdv.200900292

Cited by 105 publications

(74 citation statements)

References 29 publications

(25 reference statements)

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“…For example, plants of the genus Artemisia (Ferreira et al, 2011), extract from Zanthoxylum naranjillo (Braguine et al, 2009), crude aqueous extract of Zingiber officinale (Mostafa et al, 2011), several essential oils (Melo et al 2011;Parreira et al 2010;Caixeta et al 2011), among others, have been effective against S. mansoni. In addition, some medicinal plants have been described for clinical used against schistosomiasis, such as Myrrh (Mirazid®), an aromatic oleo-gum resin obtained from Commiphora molmol (also called Commiphora myrrha) that has been used in Egypt against schistosome infection (Abdul-Ghani et al 2009).…”

Section: Resultsmentioning

confidence: 99%

In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni

et al. 2011

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In this paper, cercariae, schistosomula, and adult Schistosoma mansoni worms were incubated in vitro with the essential oil of Piper cubeba (PC-EO) at concentrations from 12.5 to 200 μg/mL, and the viability was evaluated using an inverted microscopy. The effects of PC-EO at 100 and 200 μg/mL on the stages of S. mansoni were similar to those of the positive control (PZQ at 12.5 μg/mL), with total absence of mobility after 120 h. However, at concentrations from 12.5 to 50 μg/mL, PC-EO caused a reduction in the viability of cercariae and schistosomula when compared with the negative control groups (RPMI 1640 or dechlorinated water) or (RPMI 1640 + 0.1% DMSO or dechlorinated water + 0.1% DMSO). On the other hand, adult S. mansoni worms remained normally active when incubated with PC-EO at concentrations of 12.5 and 25 μg/mL, and their viabilities were similar to those of the negative control groups. In addition, at concentrations ranging from 50 to 200 μg/mL, separation of all the coupled adult worms was observed after 24 h of incubation, which is related to the fact of the reduction in egg production at this concentration. The main chemical constituents of PC-EO were identified by gas chromatography-mass spectrometry as being sabinene (19.99%), eucalyptol (11.87%), 4-terpineol (6.36%), β-pinene (5.81%), camphor (5.61%), and δ-3-carene (5.34%). The cytotoxicity of the PC-EO was determined, and a significant cytotoxicity was only obtained in the concentration of 200 μg/mL after 24 h treatment. The results suggest that PC-EO possesses an effect against cercariae, schistosomula, and adult worms of the S. mansoni.

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Section: Resultsmentioning

confidence: 99%

In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni

et al. 2011

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“…In this scenario, some essential oils have been recently pointed out as a promising alternative against Schistosoma mansoni Caixeta et al, 2011;Parreira et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

In vitro schistosomicidal effects of the essential oil of Tagetes erecta

Tonuci¹,

Melo²,

Dias³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The in vitro schistosomicidal effects of the essential oil obtained from Tagetes erecta L. Asteraceae, leaves (TE-EO) collected in Brazil against Schistosoma mansoni worms are reported in this paper. The oil caused a significant decrease in the motor activity at 50 μg/mL as minimal concentration after 24 h. This oil also caused death of all the parasites and the separation of coupled pairs into individual male and female at 100 μg/mL after 24 h. The viability of adult worm groups treated with the TE-EO at 100 μg/mL was similar to that of groups treated with praziquantel (positive control). In addition, the oil promoted the inhibition of eggs development at all the tested concentrations. These data indicate that the TE-EO could be considered as a promising source for the development of new schistosomicidal agents.

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“…The curcuminloaded PLGA nanoparticles caused a separation between 50% and 100% of S. mansoni couples at a concentration of 30 μM at 24 h. Separation also was noted at 20 μM during others periods evaluated. Not only curcumin, but also other plant constituents, have shown effects on separation of adult worms couples (Parreira et al 2010;Moraes et al 2011). No separation was observed in the negative control groups.…”

Section: Resultsmentioning

confidence: 99%

Curcumin-loaded into PLGA nanoparticles

et al. 2011

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The incorporation of the curcumin into poly(lactic-co-glycolic)acid (PLGA) nanospheres by the nanoprecipitation technique, the characterization of the nanoparticles and the schistosomicidal activity of the curcumin-loaded into PLGA nanospheres were reported. The incorporation process occurred with high efficiency and the images of field-emission scanning electron microscopy (FESEM) revealed the production of spherically shaped particles. According to the dynamic light scattering measurements, the particles are nanometric and monodisperse. The curcumin-loaded PLGA nanoparticles (50 and 100 μM) caused the death of all worms and a separation between 50% and 100% of Schistosoma mansoni couples at concentrations from 30 μM. Moreover, the curcumin-loaded PLGA nanoparticles also decreased the motor activity and caused partial alterations in the tegument of adult worms. This study marks the first time that schistosomicidal activity has been reported for curcumin-loaded PLGA nanoparticles.

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Antiprotozoal, Schistosomicidal, and Antimicrobial Activities of the Essential Oil from the Leaves of Baccharis dracunculifolia

Cited by 105 publications

References 29 publications

In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni

In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni

In vitro schistosomicidal effects of the essential oil of Tagetes erecta

Curcumin-loaded into PLGA nanoparticles

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