Antiprotozoal, antimycobacterial, and anti-inflammatory evaluation of Cnidoscolus chayamansa (Mc Vaugh) extract and the isolated compounds

Pérez-González, Mariana Z.; Gutiérrez-Rebolledo, Gabriel Alfonso; Yépez‐Mulia, Lilián; Rojas-Tomé, Irma Susana; Luna-Herrera, Julieta; Jiménez-Arellanes, María Adelina

doi:10.1016/j.biopha.2017.02.021

Cited by 42 publications

(42 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…in rats: aqueous extract of Pouteria sapota seeds [ 122 ], methanol extract of Martynia annua leaves [ 123 ], ethanol extract of Flourensia cernua leaves [ 124 ], aqueous extract of Enterolobium cyclocarpum bark [ 82 ], ethanol and aqueous extract C. pulcherrima aerial parts [ 125 ], aqueous extract of Passiflora edulis leaves [ 126 ], hydroalcoholic extract of Magnolia grandiflora seeds [ 127 ], and ethanol extract of Crescentia cujete fruits [ 128 ]. The same pattern was also shown in methanol extracts of leaves of Amaranthus spinosus [ 129 ], and Rauvolfia tetraphylla [ 130 ], chloroform-methanol extract of Cnidoscolus chayamansa leaves [ 131 ], aqueous extract of R. humilis fruits [ 132 ], a chloroform fraction from an ethanol extract of Tagetes erecta flowers [ 133 ], aqueous extract of Karwinskia humboldtiana seeds [ 134 ], and hydroalcoholic extract of Senna occidentalis aerial parts [ 135 ], as well as lutein and lutein ester, obtained from Tagetes erecta [ 136 ], and ethanol extract of Jatropha gossypiifolia aerial parts [ 137 ], and aqueous extract of Caladium bicolor [ 138 ].…”

Section: Toxicologysupporting

confidence: 61%

See 1 more Smart Citation

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The consumption of medicinal plants has notably increased over the past two decades. People consider herbal products as safe because of their natural origin, without taking into consideration whether these plants contain a toxic principle. This represents a serious health problem. A bibliographic search was carried out using published scientific material on native plants from Mexico, Central America, and the Caribbean, which describe the ethnobotanical and toxicological information of medicinal plants empirically considered to be toxic. A total of 216 medicinal plants belonging to 77 families have been reported as toxic. Of these plants, 76 had been studied, and 140 plants lacked studies regarding their toxicological effects. The toxicity of 16 plants species has been reported in clinical cases, particularly in children. From these plants, deaths have been reported with the consumption of Chenopodium ambrosioides, Argemone mexicana, and Thevetia peruviana. In most of the cases, the principle of the plant responsible for the toxicity is unknown. There is limited information about the toxicity of medicinal plants used in Mexico, Central America, and the Caribbean. More toxicological studies are necessary to contribute information about the safe use of the medicinal plants cited in this review.

show abstract

Section: Toxicologysupporting

confidence: 61%

“…A chloroform-methanol extract of Cnidoscolus chayamansa leaves (1000 mg/kg p.o.) [ 131 ] and an ethanol extract of Moussonia deppeana aerial parts (1000 mg/kg p.o.) [ 107 ] did not affect biochemical or hematological parameters in mice after 28 days of daily administration.…”

Section: Toxicologymentioning

confidence: 99%

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“… Pictures of plants assayed in this study and derived compounds previously reported in the literature [ 18 , 20 , 21 , 22 , 23 ]. …”

Section: Figurementioning

confidence: 99%

“…However, it is known to display anti-mutagenic activity in the bacterial cell lines TA100 and TA98 [ 16 ]. In addition, ischemia-reperfusion tests performed in mice showed its anti-inflammatory and anti-oxidant activity in the ethanolic extract [ 16 , 17 , 18 ]. These data suggests its potential prophylactic and therapeutic use in cancer treatment [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Structural Characterization of Bioactive Molecules on Prostate Cancer from Mayan Traditional Medicinal Plants

et al. 2018

View full text Add to dashboard Cite

Prostate cancer is the most common cancer in men around the world. It is a complex and heterogeneous disease in which androgens and their receptors play a crucial role in the progression and development. The current treatment for prostate cancer is a combination of surgery, hormone therapy, radiation and chemotherapy. Therapeutic agents commonly used in the clinic include steroidal and non-steroidal anti-androgens, such as cyproterone acetate, bicalutamide and enzalutamide. These few agents have multiple adverse effects and are not 100% effective. Several plant compounds and mixtures, including grape seed polyphenol extracts, lycopene and tomato preparations, soy isoflavones, and green tea extracts, have been shown to be effective against prostate cancer cell growth. In vivo activity of some isolated compounds like capsaicin and curcumin was reported in prostate cancer murine models. We prepared a library of plant extracts from traditional Mayan medicine. These plants were selected for their use in the contemporaneous Mayan communities for the treatment of different diseases. The extracts were assessed in a phenotypic screening using LNCaP prostate cancer androgen sensitive cell line, with a fixed dose of 25 μg/mL. MTT assay identified seven out of ten plants with interesting anti-neoplastic activity. Extracts from these plants were subjected to a bioguided fractionation to study their major components. We identified three compounds with anti-neoplastic effects against LNCaP cells, one of which shows selectivity for neoplastic compared to benign cells.

show abstract

“…C. chayamansa, for example, has been widely studied, there are reports about different biologics activities as antimutagenic, antioxidant, hypoglycemic, antiinflammatory, antiprotozoal and antibacterial. [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Nutraceutical Potential of Cnidoscolus aconitifolius

Sánchez-Hernández¹,

Barragán-Álvarez²,

Torres-González³

et al. 2017

ARC Journal of Nutrition and Growth

View full text Add to dashboard Cite

Antiprotozoal, antimycobacterial, and anti-inflammatory evaluation of Cnidoscolus chayamansa (Mc Vaugh) extract and the isolated compounds

Cited by 42 publications

References 31 publications

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Isolation and Structural Characterization of Bioactive Molecules on Prostate Cancer from Mayan Traditional Medicinal Plants

Nutraceutical Potential of Cnidoscolus aconitifolius

Contact Info

Product

Resources

About