Antiprotozoal Agents from Plant Sources

Phillipson, J. David; Cw, Wright

doi:10.1055/s-2006-960230

Cited by 140 publications

(82 citation statements)

References 9 publications

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“…Information on the general phytochemical constituents of Prosopis africana in the internationally accessible literature are rare, but scattered information on the presence of the two alkaloids, prosopine and prosopinine 28,29 and tannins which constitutes about 18% of the stem bark extract Earlier workers have demonstrated that, alkaloids, tannins and anthraquinones, which were also detected in most of the extracts (Table1) may possess antitrypanosomal and antitryprotozoal effects 4,30,31 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-trypanosomal Properties of Four Extracts of Leaves, Stem and Root Barks of <i>Prosopis africana</i> in Laboratory Animals

Atawodi¹,

Ogunbusola²

2010

Biokemistri

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Qualitative phytochemical and anti-trypanosomal properties of the petroleum ether, chloroform, methanol and aqueous extracts, obtained by cold extraction from the leaves, stem bark and roots of Prosopis africana were evaluated. The methanolic and aqueous extracts of the stem bark and leaves of the plant contained alkaloids, saponins, tannins and flavonoids. Anthraquinone was present in the stem bark methanolic extract and in the methanolic and aqueous extracts of the root as well as the aqueous extract of the leaves. Resins was present in the petroleum ether and chloroform extracts of the stem bark and leaves, while tannins was detected in the methanol and aqueous extracts of the stem bark and leaves of the plant in addition to the petroleum ether and chloroform extracts of the root bark. All the solvent extracts showed strong in vitro anti-trypanosomal activity and 2 and 4 mg/ml, but in vivo only the methanolic extract of the leaves displayed the most promising anti-trypanosomal effect at 200 mg/kg dose. Hence, Prosopis africana extracts possess significant anti-trypanosomal activity to warrant bioassay-guided evaluation and identification of the active principle.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-trypanosomal Properties of Four Extracts of Leaves, Stem and Root Barks of <i>Prosopis africana</i> in Laboratory Animals

Atawodi¹,

Ogunbusola²

2010

Biokemistri

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“…The antimalarial activity has been linked to a range of compounds including anthroquinones, berberine, flavonoids, limonoids, naphthquinones, sesquiterpenes, quassinoids, indol and quinoline alkaloids and many of the genera represented by the plants collected in this work have been shown to contain these compounds 21 .…”

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confidence: 92%

Preliminary assessment of medicinal plants used as antimalarials in the southeastern Venezuelan Amazon

Caraballo

Rodrı́guez-Acosta

2004

Rev. Soc. Bras. Med. Trop.

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“…All the parasites tested cause inflammatory conditions and xylopic acid has been shown to possess anti-inflammatory properties (Obiri et al, 2014). Terpenes are well known to be active against protozoan parasites (Phillipson and Wright, 1991). This could be the reason for the activity exhibited by xylopic acid.…”

Section: Resultsmentioning

confidence: 99%

In vitro activity of selected Ghanaian medicinal plants against parasites: Giardia lamblia, Entamoeba histolytica and Naegleria fowleri

Kyere-Davies¹,

Agyare²,

Boakye³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Entamoeba histolytica and Giardia lamblia are parasitic protozoa that cause gastrointestinal disorders such as diarrhea and dysentery. Naegleria fowleri is a free living amoeba that causes primary amoebic meningoencephalitis. However, there are limited treatments for these parasitic diseases. Extracts, fractions from extracts and some isolated compounds from selected Ghanaian medicinal plants were screened against Naegleria fowleri, Giardia lamblia and Entamoeba histolytica in the search for newer and safer agents for the treatment of infections caused by these parasites. Of all the extracts and compounds tested for the activity against E. histolytica, only xylopic acid and geraniin were active with

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Antiprotozoal Agents from Plant Sources

Abstract: Protozoa are responsible for a number of serious tropical diseases including amoebiasis, leishmaniasis, malaria, and trypanosomiasis. New drugs are required for the treatment of these diseases and the potential of plants to produce new clinical agents is discussed.

Cited by 140 publications

References 9 publications

Evaluation of Anti-trypanosomal Properties of Four Extracts of Leaves, Stem and Root Barks of <i>Prosopis africana</i> in Laboratory Animals

Evaluation of Anti-trypanosomal Properties of Four Extracts of Leaves, Stem and Root Barks of <i>Prosopis africana</i> in Laboratory Animals

Preliminary assessment of medicinal plants used as antimalarials in the southeastern Venezuelan Amazon

In vitro activity of selected Ghanaian medicinal plants against parasites: Giardia lamblia, Entamoeba histolytica and Naegleria fowleri

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