Antiprotozoal Activity of Flavonoid Glycosides Isolated from<i>Clidemia sericea</i>. and<i>Mosquitoxylon jamaicense</i>.

Montenegro, Héctor; González, José; Ortega-Barrı́a, Eduardo; Cubilla‐Rios, Luis

doi:10.1080/13880200701214821

Cited by 14 publications

(9 citation statements)

References 17 publications

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“…Various tannins [2] [3], flavonoids [4 -6], and triterpenoids [7] [8] are widely distributed in plants of the family Melastomataceae. Many of these compounds exhibit antioxidant [2] [4], anti-inflammatory [3], cytotoxic [4] [7], antifungal [5], antiprotozoal [6], and antimicrobial [8] activities.…”

mentioning

confidence: 99%

A New Ferulic Acid Ester, a New Ellagic Acid Derivative, and Other Constituents from Pachycentria formosana: Effects on Neutrophil Pro‐Inflammatory Responses

Cho

Lee

Hwang

et al. 2011

Chemistry & Biodiversity

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A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4 : 3',4'-bis(O,O-methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3-epibetulinic acid (9) exhibited potent inhibition (IC(50) values ≤ 21.8 μM) of O₂(-) generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3-O-[(E)-feruloyl]ursolic acid (8), 3-epibetulinic acid (9), and lawsonic acid (10) also inhibited fMLP/CB-induced elastase release with IC(50) values ≤ 18.6 μM.

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confidence: 99%

A New Ferulic Acid Ester, a New Ellagic Acid Derivative, and Other Constituents from Pachycentria formosana: Effects on Neutrophil Pro‐Inflammatory Responses

Cho

Lee

Hwang

et al. 2011

Chemistry & Biodiversity

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“…A variety of glycosides have been investigated for potential antimalarial activities (Traore et al, 2000;Schmieg et al, 2003;Liu et al, 2007;Montenegro et al, 2007;AbdelSattar et al, 2008;Lee et al, 2008;Park et al, 2008;Tasdemir et al, 2008), and mechanistic studies have focused predominantly on the nature of cell membrane disruption by glycosides. The resin glycosides cryptophilic acids 1 and 3 interfered with and disrupted glycolipid biosynthesis on the cell surface of the parasite, and exhibited antimalarial activity (Tasdemir et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Glycosides, such as triterpenoid saponins, flavonol glycosides, pregnane glycosides, stilbene glycosides, and resin glycosides (Traore et al, 2000;Schmieg et al, 2003;Liu et al, 2007;Montenegro et al, 2007;Abdel-Sattar et al, 2008;Park et al, 2008;Tasdemir et al, 2008), have been reported to possess antimalarial activities.…”

Section: Introductionmentioning

confidence: 99%

In vivoantimalarial activities of glycoalkaloids isolated from Solanaceae plants

Chen¹,

Li²,

Sun³

et al. 2010

Pharmaceutical Biology

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“…A compound (lonchocarpol A; 72 ) from Erythrina fusca bark showed antiplasmodial activity against P. falciparum K1 (IC 50 : 9.18 μg/ml; SI: 1.43, NCI‐H187 cells; Innock, Rukachaisirikul, & Suksamrarn, ). Montenegro et al () evaluated the antimalarial activity of three isolates from Mosquitoxylon jamaicense ( 73 ; 2″,6″‐ O ‐digalloylvitexin) and Clidemia sericea ( 74 [2″‐ O ‐galloylvitexin] and 75 [phloridzin]) against P . falciparum W2.…”

Section: Natural Flavonoids As Potential Leads For the Treatment Of Mmentioning

confidence: 99%

Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue

Boniface

Ferreira

2019

Phytotherapy Research

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Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually with over 500,000 deaths. Among the NTDs, some of the most severe consist of leishmaniasis, Chagas disease, and dengue. The impact of the combined NTDs closely rivals that of malaria. According to the World Health Organization, 216 million cases of malaria were reported in 2016 with 445,000 deaths. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures. Flavonoids are a class of compounds that has been the subject of considerable scientific interest. New developments of flavonoids have made promising advances for the potential treatment of malaria, leishmaniasis, Chagas disease, and dengue, with less toxicity, high efficacy, and improved bioavailability. This review summarizes the current standings of the use of flavonoids to treat malaria and neglected diseases such as leishmaniasis, Chagas disease, and dengue. Natural and synthetic flavonoids are leading compounds that can be used for developing antiprotozoal and antiviral agents. However, detailed studies on toxicity, pharmacokinetics, and mechanisms of action of these compounds are required to confirm the in vitro pharmacological claims of flavonoids for pharmaceutical applications. Highlights In the current review, we have tried to compile recent discoveries on natural and synthetic flavonoids as well as their implication in the treatment of malaria, leishmaniasis, Chagas disease, and dengue. A total of 373 (220 natural and 153 synthetic) flavonoids have been evaluated for antimalarial, antileishmanial, antichagasic, and antidengue activities. Most of these flavonoids showed promising results against the above diseases. Reports on molecular modeling of flavonoid compounds to the disease target indicated encouraging results. Flavonoids can be prospected as potential leads for drug development; however, more rigorously designed studies on toxicity and pharmacokinetics, as well as the quantitative structure–activity relationship studies of these compounds, need to be addressed.

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Antiprotozoal Activity of Flavonoid Glycosides Isolated fromClidemia sericea. andMosquitoxylon jamaicense.

Cited by 14 publications

References 17 publications

A New Ferulic Acid Ester, a New Ellagic Acid Derivative, and Other Constituents from Pachycentria formosana: Effects on Neutrophil Pro‐Inflammatory Responses

A New Ferulic Acid Ester, a New Ellagic Acid Derivative, and Other Constituents from Pachycentria formosana: Effects on Neutrophil Pro‐Inflammatory Responses

In vivoantimalarial activities of glycoalkaloids isolated from Solanaceae plants

Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue

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