Antiprotozoal activity of dehydroabietic acid derivatives against <i>Leishmania donovani</i> and <i>Trypanosoma cruzi</i>

Vahermo, Mikko; Krogerus, Sara; Nasereddin, Abedelmajeed; Kaiser, Marcel; Brun, Reto; Jaffe, Charles L.; Yli‐Kauhaluoma, Jari; Moreira, Vânia M.

doi:10.1039/c5md00498e

Cited by 17 publications

(19 citation statements)

References 33 publications

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“…ex Endl. (African juniper) berries have shown promising trypanocidal activity together with a quinone derivative of dehydroabietic acid, 12-methoxycarnosic acid, and a few others [3]. A complete survey of abietane type terpenois and their biological activities is reviewed by Gonzalez [22], covering literature from 1980 up to 2014.…”

Section: Terpenoidsmentioning

confidence: 99%

“…However, on the treatment of patients in the chronic phase, drug efficacy decreases dramatically curing only 5-20% of the cases. In addition to this limited therapeutic potential, both compounds feature high toxicity [3].…”

Section: Natural Remedies In the Fight Against Parasitesmentioning

confidence: 99%

“…However, this disease is expanding worldwide due to migration phenomena. The parasites that have a kinetoplast and a single flagellum are characterized as Trypanosomatids [3].…”

Section: Natural Remedies In the Fight Against Parasites 94mentioning

confidence: 99%

“…In other hand, protozoan diseases represent an important health threat in countries of tropical and subtropical regions, causing mortality to their populations [3]. Many neglected tropical diseases (NTDs) transmitted by parasites are reported to have life cycles including man as a secondary host, in which they cause disease.…”

Section: Introductionmentioning

confidence: 99%

“…Many neglected tropical diseases (NTDs) transmitted by parasites are reported to have life cycles including man as a secondary host, in which they cause disease. About 37 million individuals are presently (2), and taxol (3).…”

Section: Introductionmentioning

confidence: 99%

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Can the Cure for Chagas’ Disease be Found in Nature?

Vaz¹

2017

Natural Remedies in the Fight Against Parasites

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Nature is a skilled factory that produces a wide variety of secondary metabolites known as natural products. Those compounds synthesized by living organisms are usually related to their vital processes. Many drugs used nowadays, had its origins in medicinal plants and other organisms such as herbs, fungi and sponges. Hence, those sources constitute a viable alternative to conventional medicine in many developing countries. In other hand, protozoan diseases like Chagas, represent a health threat causing mortality to populations around the world. The classic treatment for Chagas' disease is chemotherapic and includes benznidazole and nifurtimox, although, the search for new drugs still remains. Triatomines that may spread Chagas can also be controlled making use of the insecticide property of certain plants. After literature survey it was found, classes of natural products, plant extracts, essential oils, and other natural sources that have shown activity against T. cruzi. In this context, many substances were tested in vitro and in vivo assays to verify trypanocidal efficacy. Promising results were published regarding to compounds arising from plants and sponges that showed high toxicity on different forms of the parasite with low toxicity on mammalian cells, although few were clinically tested on Chagas' disease.

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Section: Terpenoidsmentioning

confidence: 99%

Section: Natural Remedies In the Fight Against Parasitesmentioning

confidence: 99%

“…However, this disease is expanding worldwide due to migration phenomena. The parasites that have a kinetoplast and a single flagellum are characterized as Trypanosomatids [3].…”

Section: Natural Remedies In the Fight Against Parasites 94mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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