Antiproteinuria Effect of Calcitriol in Patients With Chronic Kidney Disease and Vitamin D Deficiency: A Randomized Controlled Study

Wu, Chia‐Chao; Liao, Min; Hsiao, Po-Jen; Lu, Cheng Wei; Hsu, Yu‐Juei; Lu, Kuo‐Cheng; Chu, Pauling

doi:10.1053/j.jrn.2019.09.001

Cited by 16 publications

(18 citation statements)

References 54 publications

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“…The majority of patients from nephrology at RMH were treated for chronic kidney disease (CKD). Vitamin D levels are generally low in these patients, as CKD is associated with low levels of vitamin D, especially in patients with end-stage renal disease and kidney transplant recipient 55–59. Our findings are consistent with results from previous studies that demonstrated the association between low vitamin D levels and CKD.…”

Section: Discussionsupporting

confidence: 91%

Vitamin D status in an Australian patient population: a large retrospective case series focusing on factors associated with variations in serum 25(OH)D

et al. 2020

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ObjectivesTo investigate whether sex, age, medical specialty and seasonal variations in serum concentration of 25-hydroxy vitamin D (25(OH)D) are evident among an Australian patient population.DesignRetrospective study analysing the results of serum 25(OH)D lab tests and vitamin D supplementation from Royal Melbourne Hospital (RMH) between 2014 and 2017.SettingTertiary healthcare centre in Victoria, Australia.Participants30 023 patients (inpatient and outpatient) who had their serum 25(OH)D levels measured at RMH between 2014 and 2017.Main outcome measuresSerum 25(OH)D levels stratified according to patients’ sex, age and medical specialty admitted to, as well as the season and year (2014 to 2017) 25(OH)D level was measured.ResultsMean serum 25(OH)D level of study population was 69.9 nmol/L (95% CI 69.5 to 70.2). Only 40.2% patients in this cohort were sufficient in vitamin D (>75 nmol/L). On average, 25(OH)D levels in male patients were 6.1 units (95% CI 5.4 to 6.9) lower than in females. Linear regression analysis found that 25(OH)D levels increased by 0.16 unit (95% CI 0.14 to 0.18) for every year increase in age. One-way analysis of variance showed patients from neurology had the highest average 25(OH)D level, 76.8 nmol/L (95% CI 74.2 to 79.3) compared with other medical specialties. Mean 25(OH)D level during winter, 64.9 nmol/L (95% CI 64.2 to 65.6) was significantly lower compared with other seasons despite supplementation. Average 25(OH)D level measured in 2014, 71.5 nmol/L (95 CI% 70.8 to 72.2) was significantly higher than levels measured in 2016–2017.ConclusionsThere is a sex, age, medical specialty, seasonal and yearly variation in vitamin D status in an Australian patient population. The association between low vitamin D status and winter despite supplementation suggests other interventions are required to boost serum 25(OH)D levels.

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Section: Discussionsupporting

confidence: 91%

Vitamin D status in an Australian patient population: a large retrospective case series focusing on factors associated with variations in serum 25(OH)D

et al. 2020

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“…The main function of the kidneys is to remove wastes and excess water from the body. It is reported that patients with kidney disease often have low levels of vitamin D in their blood [ 105 , 106 ]. Furthermore, people with reduced kidney function develop alterations levels of phosphorus and calcium in the blood.…”

Section: Nutrients and Bioactive Compoundsmentioning

confidence: 99%

Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives

Askari

Sanadgol

Azarnezhad

et al. 2021

Heliyon

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Recently, the novel coronavirus disease 2019 , has attracted the attention of scientists where it has a high mortality rate among older adults and individuals suffering from chronic diseases, such as chronic kidney diseases (CKD). It is important to elucidate molecular mechanisms by which COVID-19 affects the kidneys and accordingly develop proper nutritional and pharmacological strategies. Although numerous studies have recently recommended several approaches for the management of COVID-19 in CKD, its impact on patients with renal diseases remains the biggest challenge worldwide. In this paper, we review the most recent evidence regarding causality, potential nutritional supplements, therapeutic options, and management of COVID-19 infection in vulnerable individuals and patients with CKD. To date, there is no effective treatment for COVID-19-induced kidney dysfunction, and current treatments are yet limited to anti-inflammatory (e.g. ibuprofen) and anti-viral medications (e.g. Remdesivir, and Chloroquine/Hydroxychloroquine) that may increase the chance of treatment. In conclusion, the knowledge about kidney damage in COVID-19 is very limited, and this review improves our ability to introduce novel approaches for future clinical trials for this contiguous disease.

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“…Studies have shown that people who are exposed to sun or ultraviolet light-irradiated olive oil and linseed oil can resist rickets, and further research has found that the active anti-chondrosis component in humans is vitamin D [14]. Vitamin D (referred to as VD) is a fat-soluble vitamin consisting of a group of sterol derivatives with anti-caries effects and a similar structure [15].…”

Section: Discussionmentioning

confidence: 99%

The correlation between vitamin D and maternal/infant outcomes, inflammatory response in pregnant women

Wei¹,

Jiang²,

Qiu³

et al. 2020

Preprint

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Purposes To analyze the effects of vitamin D deficiency in pregnant women on common adverse pregnancy outcomes and small for gestational age (SGA) and to detect the expression of inflammatory factors in pregnant women to provide a theoretical basis for the treatment of vitamin D deficiency in pregnant women. Methods Serum samples from pregnant women from January 2015 to December 2015 were collected to measure the 25-(OH)D level. The effects of maternal age, pregnancy, season, parity and temperature on vitamin D levels in pregnant women were recorded. Then, the relationship between vitamin D levels and gestational diabetes mellitus, gestational hypertension, premature rupture of membranes, cesarean section, premature delivery and spontaneous abortion, and neonatal gestational age were analyzed. The expression of IL-6 and TNF-α in serum was detected by RT-PCR and western blot. Results The incidence of vitamin D deficiency, insufficiency and sufficiency in pregnant women in this region was 83.28%, 15.36% and 1.36%, respectively. Age, pregnancy, sampling season and parity were the influencing factors on vitamin D level, and multivariate logistic regression analysis showed that summer, autumn and temperature were protective factors for adequate vitamin D in pregnant women (P <0.05). Vitamin D levels in pregnant women were associated with preterm birth, spontaneous abortion and SGA. The incidences of preterm birth, spontaneous abortion and SGA were higher in the vitamin D deficiency group (P<0.05). ConclusionThe serum vitamin D level of pregnant women in this area is low and is affected by multiple factors such as age, pregnancy, season, parity and temperature. Low vitamin D levels can increase the risk of premature birth, spontaneous abortion and SGA in pregnant women, and its low expression is common. As it also leads to inflammation, increasing the level of vitamin D in the serum of pregnant women can effectively reduce the occurrence of related diseases.

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Antiproteinuria Effect of Calcitriol in Patients With Chronic Kidney Disease and Vitamin D Deficiency: A Randomized Controlled Study

Cited by 16 publications

References 54 publications

Vitamin D status in an Australian patient population: a large retrospective case series focusing on factors associated with variations in serum 25(OH)D

Vitamin D status in an Australian patient population: a large retrospective case series focusing on factors associated with variations in serum 25(OH)D

Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives

The correlation between vitamin D and maternal/infant outcomes, inflammatory response in pregnant women

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