Antiproliferative potential of Artemisia capillaris polysaccharide against human nasopharyngeal carcinoma cells

Feng, Guo-fang; Wang, Xiaoqing; You, Changxuan; Cheng, Xiaohua; Han, Zeli; Zong, Liang; Zhou, Changjiang; Zhang, Meikui

doi:10.1016/j.carbpol.2012.10.024

Cited by 25 publications

(12 citation statements)

References 20 publications

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“…Similar to the in vitro results, ACE-63 increased the expression of cleaved caspase-3 and TUNEL-positive cells in organotropic ex vivo models. These findings are consistent with previous reports that AC extract induced apoptotic cell death in different cancer types including oral and breast cancers, although sources of AC were different (Cha et al, 2009;Choi and Kim, 2013;Feng et al, 2013;Kim et al, 2008).…”

Section: Discussionsupporting

confidence: 93%

“…Artemisia capillaris (AC) is widely used as a traditional medicine to treat hepatitis, liver cholestasis, jaundice, gallbladder dysfunction, and digestive system diseases (Aniya, Shimabukuro, Shimoji, et al, 2000;Bora and Sharma, 2011;Cha, Jeong, et al, 2005;Jang, Kim, Lee, Inn, & Lee, 2015;Mase et al, 2010). Recently, AC extract was shown to be an effective anticancer drug against breast cancer, oral squamous cell carcinoma, multiple myeloma, nasopharyngeal carcinoma, and skin cancer (Cha, Moon, Kim, Cha, & Lee, 2009;Choi and Kim, 2013;Feng et al, 2013;Kim, Bahn, Hah, Gang, & Ha, 2008;Lee et al, 2014).…”

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confidence: 99%

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An ethyl acetate fraction of Artemisia capillaris (ACE‐63) induced apoptosis and anti‐angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma

Jung

Rumman

Yan

et al. 2018

Phytotherapy Research

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In cancer treatment, herbal medicines may be a good choice because of the reduced risk of adverse side effects. Artemisia capillaris has been recognized as a promising candidate due to its hepatoprotective effects. Herein, we investigated whether A. capillaris-derived fraction (ACE-63) could inhibit the progression of hepatocellular carcinoma (HCC) and its underlying mechanism. In this study, ACE-63 effectively inhibited the growth and proliferation of HCC cells. ACE-63 induced apoptosis, as observed using Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, which was accompanied with increases in cleaved Poly (ADP-ribose) polymerase (PARP) and caspase-3 in HCC cells. Additionally, the pro-apoptotic effect of ACE-63 was demonstrated by a decrease in the expression of the X-linked inhibitor of apoptosis protein (XIAP) and survivin via a loss of mitochondrial membrane potential. In an ex vivo model, ACE-63 significantly inhibited tumor cell growth and induced apoptosis by increasing the expression of cleaved caspase-3 and DNA fragmentation. In addition, ACE-63 decreased the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor and inhibited tube formation of human umbilical vein endothelial cells. A mechanistic study revealed that ACE-63 effectively suppressed the PI3K/AKT/mTOR signaling pathways, which were observed as a target signaling by phosphokinase array. Taken together, our findings demonstrate that ACE-63 could not only efficiently induce apoptosis but also inhibit the growth/angiogenesis of human HCC cells by blocking the PI3K/AKT/mTOR signaling pathway, suggesting that ACE-63 may be a new chemotherapeutic candidate against HCC.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

An ethyl acetate fraction of Artemisia capillaris (ACE‐63) induced apoptosis and anti‐angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma

Jung

Rumman

Yan

et al. 2018

Phytotherapy Research

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“…Extracts were prepared and analyzed by Western blotting with antibody to Bax and cytochrome c. β-actin was monitored as loading control DOI:http://dx.doi.org/10.7314/APJCP.2015.16.3.863 Anti-cancer Properties of a Sesquiterpene Lactone-bearing Fraction from Artemisia khorassanica c in SLAK-induced apoptosis in the melanoma cells. This outcome would be in line with other reports that suggested an anti-tumor activity of sesquiterpene lactone from several Artemisia species was mediated through upregulation of Bax and cytochrome c proteins Feng et al, 2013). To date, the precise mechanism(s) underlying the pro-apoptotic effect of Artemisia in melanoma/other transformed cell lines remains unclear.…”

Section: Discussionsupporting

confidence: 90%

“…The Artemisia genus has been used in folk medicine for many years; numerous reports have indicated a vast range of biological effects associated with different Artemisia species (Abad Martinez et al, 2012;Choi et al, 2013). Among the various chemical agents found in these plants, sesquiterpene lactones have been proven to impart anticancer effects (Tan et al, 1998;Firestone et al, 2009;Firestone 2009;Lu 2009;Zhai 2010;Feng 2013).…”

Section: Discussionmentioning

confidence: 99%

Anti-cancer Properties of a Sesquiterpene Lactone-bearing Fraction from Artemisia khorassanica

Rabe

Emami²,

Iranshahi³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…It also has been reported to have various functions against inflammation (6), cancer (8), Helicobacter pylori infection (9) and hepatotoxicity (10). Recently, it was reported that 70% ethanol extract of Ac exerted inhibitory effects on atopic dermatitis-like skin lesions via the downregulation of serum histamine content and IgE expression (11).…”

Section: Introductionmentioning

confidence: 99%

The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis

Son¹,

Lee²,

Heo

et al. 2017

International Journal of Molecular Medicine

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Artemisia capillaris, which belongs to the Asteraceae family and the genus Artemisia, has been reported to exert inhibitory effects on diabetes, cancer and inflammation. In this study, in order to enhance the bioactivity potential of the leaves of Artemisia by Ganoderma lucidum mycelium, we prepared aqueous samples of Artemisia capillaris (Ac) leaves, Ganoderma lucidum (Gl) and aqueous fractions produced by the solid fermentation of Ganoderma lucidum on Artemisia capillaris leaves (afAc/Gl). Thereafter, we evaluated whether these samples have potential to attenuate inflammation-related symptoms in an amimal model of 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis. We found that afAc/Gl exhibited enhanced anti-inflamamatory activity following the solid fermentation process when compared with Ac or Gl on ear thickness, ear epidermal thickness and eosinophil infiltration in the skin tissues. The expression of nitric oxide (NO) synthases (NOSs) was measured by immunohistochemical staining. The results revealed that afAc/Gl decreased endothelial NOS and inducible NOS expression compared with the DNFB group, while neuronal NOS expression was not altered. By comparing NO production, we found that as opposed to Ac, afAc/Gl has potential to inhibit atopic dermatitis-related symptoms during the inflammatory event. As regards matrix metalloproteinase (MMP) expression patterns, afAc/Gl exerted potent inhibitory activity on the mRNA expression of MMP-2, -7, -9, -12, -14 and -19. Taken together, these results suggest that the solid state fermentation of Ac by Gl is an effective strategy to obtaining useful ingredients which are converted into valuable compounds during an atopic inflammatory insult.

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Antiproliferative potential of Artemisia capillaris polysaccharide against human nasopharyngeal carcinoma cells

Cited by 25 publications

References 20 publications

An ethyl acetate fraction of Artemisia capillaris (ACE‐63) induced apoptosis and anti‐angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma

An ethyl acetate fraction of Artemisia capillaris (ACE‐63) induced apoptosis and anti‐angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma

Anti-cancer Properties of a Sesquiterpene Lactone-bearing Fraction from Artemisia khorassanica

The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis

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