Antiproliferative pharmacophore azo-hydrazone analogue BT-1F exerts death signalling pathway targeting STAT3 in solid tumour

Banumathi,; Sherapura, Ankith; Malojirao, Vikas H.; Zabiulla,; Sharath, B S; Thirusangu, Prabhu; Mahmood, Riaz; Kumari, N. Suchetha; Baliga, Shrinath M; Khanum, Shaukath Ara; Prabhakar, B.T.

doi:10.1007/s43440-021-00345-w

Cited by 4 publications

(3 citation statements)

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“…Furthermore, compound 10 attenuated solid tumor growth without inducing significant toxicological side effects. Recently, Banumathi et al showed that the azo-hydrazone analog 10 (Figure 9) exerted chemosensitivity specifically against EAC and A549 cells without altering their normal counterpart [113]. It was found that the antiproliferative activity of 10 was due to the induction of apoptosis by inhibiting the STAT3 signal.…”

Section: Antitumor Actionmentioning

confidence: 99%

“…According to the evaluation of Lis et al, acylhydrazone 9 (Figure 8) induced apoptosis in erlotinib-resistant neoplasms as a result of selective STAT3 inhibition [40]. Recently, Banumathi et al showed that the azo-hydrazone analog 10 (Figure 9) exerted chemosensitivity specifically against EAC and A549 cells without altering their normal counterpart [113]. It was found that the antiproliferative activity of 10 was due to the induction of apoptosis by inhibiting the STAT3 signal.…”

Section: Antitumor Actionmentioning

confidence: 99%

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Acylhydrazones and Their Biological Activity: A Review

et al. 2022

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Due to the structure of acylhydrazones both by the pharmacophore –CO–NH–N= group and by the different substituents present in the molecules of compounds of this class, various pharmacological activities were reported, including antitumor, antimicrobial, antiviral, antiparasitic, anti-inflammatory, immunomodulatory, antiedematous, antiglaucomatous, antidiabetic, antioxidant, and actions on the central nervous system and on the cardiovascular system. This fragment is found in the structure of several drugs used in the therapy of some diseases that are at the top of public health problems, like microbial infections and cardiovascular diseases. Moreover, the acylhydrazone moiety is present in the structure of some compounds with possible applications in the treatment of other different pathologies, such as schizophrenia, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. Considering these aspects, we consider that a study of the literature data regarding the structural and biological properties of these compounds is useful.

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Section: Antitumor Actionmentioning

confidence: 99%

Section: Antitumor Actionmentioning

confidence: 99%

Acylhydrazones and Their Biological Activity: A Review

et al. 2022

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“…1 Introduction 4-Hydrazonyl quinazolines are compounds that hybridize two pharmacophore cores: a quinazoline 1,2 and a hydrazone. 3,4 Quinazolines constitute a class of heterocycles that contain two fused aromatic benzene and pyrimidine rings and exhibit a plethora of biological activities. [5][6][7][8][9][10] Hydrazones contain a characteristic R 1 R 2 CvN-NHR 3 functional group which due to its isomerization and nucleophilic, electrophilic and acidic sites gives rise to versatile uses of their carrier compounds.…”

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confidence: 99%