Antiproliferative effects of the major tea polyphenol, (−)-epigallocatechin gallate and retinoic acid in cervical adenocarcinoma

Yokoyama, Msatoshi; Noguchi, Mitsuyo; Nakao, Yasuo; Ysunaga, Makio; Yamasaki, Fumio; Iwasaka, Tsuyoshi

doi:10.1016/j.ygyno.2007.10.013

Cited by 29 publications

(19 citation statements)

References 37 publications

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“…On the other hand, cervical adenocarcinoma cell line TMCC-1 seems to be less sensitive to EGCG exposure compared to the another adenocarcinoma line HeLa (Yokoyama et al, 2008) possibly indicating the differences in copies of integrated HPV18 genome per cells.…”

Section: Flavanolsmentioning

confidence: 93%

“…As a characteristic feature, the generally lower cytotoxic activity of EGCG in cervical adenocarcinoma cell lines compared to their squamous cell counterparts is reported (Noguchi et al, 2006;Yokoyama et al, 2008). In this way, EGCG can express more effective growth inhibitory activity in squamous cell carcinoma cell lines SiHa and ME180 than in adenocarcinoma lines TMCC-1 and HeLa (Yokoyama et al, 2004;Zou et al, 2010) and CaSki cells reveal higher sensitivity to EGCG than HeLa cells (Qiao et al, 2009).…”

Section: Flavanolsmentioning

confidence: 95%

“…Moreover, cervical adenocarcinomas are relatively more aggressive, tend to metastasize earlier and are less sensitive to chemoand radiotherapy than their squamous cell counterparts. Also, their prognosis is less favorable exerting somewhat lower five-year survival rate than that of squamous cell carcinomas (Noguchi et al, 2006;Zhang B et al, 2006;Yokoyama et al, 2008;Al-Hazzani and Alshatwi, 2011). Therefore, the development of new anticancer drugs for the treatment of adenocarcinomas is an especially important task.…”

Section: Human Cervical Cancer Cell Lines Used For Studies Of Flavonomentioning

confidence: 99%

“…The potency of anticancer action of EGCG in human cervical cells is dependent also on the grade of malignancy as this dietary flavanol is in general more effective in premalignant cells and the sensitivity to EGCG decreases with the progression of carcinogenic process (Yokoyama et al, 2004;Noguchi et al, 2006;Yokoyama et al, 2008). At the same time the cytotoxic activity of EGCG on normal cervical cells is much lower than on the respective cancerous cells (Yang et al, 2003;Yokoyama et al, 2004).…”

Section: Flavanolsmentioning

confidence: 99%

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Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeutic strategies and anticancer agents is an urgent priority. Plants have remained an important source in the search for novel cytotoxic compounds and several polyphenolic flavonoids possess antitumor properties. In this review article, data about potential anticarcinogenic activity of common natural flavonoids on various human cervical cancer cell lines are compiled and analyzed showing perspectives for the use of these secondary metabolites in the treatment of cervical carcinoma as well as in the development of novel chemotherapeutic drugs. Such anticancer effects of flavonoids seem to differentially depend on the cellular type and origin of cervical carcinoma creating possibilities for specific targeting in the future. Besides the cytotoxic activity per se, several flavonoids can also contribute to the increase in efficacy of conventional therapies rendering tumor cells more sensitive to standard chemotherapeutics and irradiation. Although the current knowledge is still rather scarce and further studies are certainly needed, it is clear that natural flavonoids may have a great potential to benefit cervical cancer patients.

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Section: Flavanolsmentioning

confidence: 93%

Section: Flavanolsmentioning

confidence: 95%

Section: Human Cervical Cancer Cell Lines Used For Studies Of Flavonomentioning

confidence: 99%

Section: Flavanolsmentioning

confidence: 99%

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Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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“…Recent studies have recognized that tea has health-protecting benefits that include antioxidative [6–8], antimicrobial [9, 10], antiviral [11, 12], and antitumor [13–16] activities and abilities to prevent diabetes [17], obesity [18], leukemia [19], Parkinson's disease [20], and cardiovascular disease [21]. …”

Section: Introductionmentioning

confidence: 99%

The Galloyl Catechins Contributing to Main Antioxidant Capacity of Tea Made fromCamellia sinensisin China

Zhao

Liu

et al. 2014

The Scientific World Journal

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Total polyphenol content, catechins content, and antioxidant capacities of green, dark, oolong, and black teas made from Camellia sinensis in China were evaluated. The total polyphenol content of 20 samples of tea was in the range of 7.82–32.36%. Total catechins content was in the range of 4.34–24.27%. The antioxidant capacity of tea extract was determined by the oxygen radical absorbance capacity (ORAC) test and the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging test. Total polyphenol content, catechins content, and antioxidant capacity decreased in the following order: green > oolong > black > dark tea. A positive correlation existed between the antioxidant capacity and total polyphenol content or catechins content (R 2 = 0.67–0.87). The antioxidant capacities of five major catechins (epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epicatechin, epigallocatechin, and catechin) were determined by online HPLC DPPH radical-scavenging; the antioxidant activity of tea was mainly attributed to the esterified catechins (EGCG or ECG).

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Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds

Fujiki

Sueoka

Watanabe

et al. 2014

J Cancer Res Clin Oncol

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Antiproliferative effects of the major tea polyphenol, (−)-epigallocatechin gallate and retinoic acid in cervical adenocarcinoma

Cited by 29 publications

References 37 publications

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

The Galloyl Catechins Contributing to Main Antioxidant Capacity of Tea Made fromCamellia sinensisin China

Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds

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