Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro

Cytotoxic Evaluation and DNA Binding Ability of Catalytically Synthesized New Steroidal Lactones

“…During cytotoxicity experiments (MTT assay) the compound 5 has been identified showing potential anticancer behaviour of IC 50 =19.27 against MCF-7 cell line. This study also supports the reported studies about specialty of steroid as anticancer against leukaemia and breast cancer [25]. The molecular docking studies undertaken in the present work are in total agreement with the non-covalent mode of binding (minor groove binding).…”

“…Anticancer study showed that the compound 5 was most active towards MCF-7 cell among the four cancer cell lines with IC 50 =19.41 ± 0.7 while the compound 5 was more active against HeLa with IC 50 =19.27 ± 0.8. These results support the previous studies that steroids can regulate a variety of biological processes and specific potential drug candidates for the treatment of leukaemia and breast cancers [25]. The results indicate that the presence of electron withdrawing groups chlorine and acetoxy at position 3β has an impact on the bioactivity of the compounds [26,27].…”

Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitro

“…Apoptosis was revealed by nuclear changes such as chromatin condensation and nuclear fragmentation. The necrotic and the late-apoptotic cells were identified as cells with PI uptake, which indicates the loss of membrane integrity, the cell nuclei being stained red 15 .…”

Antiproliferative and antimetastatic properties of D-ring modified estrogen analogs on cervical cancer cell lines

“…Natural and natural-related compounds are the most commonly used drugs worldwide; hence, the first anticancer agents with a steroid structure were of herbal origin [49][50][51][52][53][54][55]. Besides natural plant steroids, some endogenous steroid metabolites are also reported to be potent antiproliferative agents [10][11][12][13][14][15][16]56].…”