Abstract:A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), 1H NMR, and IR spectroscopy in order to seek their cytotoxic and proliferation effects on human small lung (A549) and cervical (HeLa) cancer cell lines with biochemical assays. All of the synthesized compounds showed antiproliferative effects to different extents.
“…Mass spectrometry has become increasingly popular in the characterization of coordination compounds due to the development of soft ionization methods over the last two decades. However, most of these studies have been carried out with atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), and especially electrospray ionization (ESI) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The studies performed by classical ionization methods are very limited [16,[21][22][23][24][25].…”
Mono-, di-and trinuclear complexes of Fe(III), Co(II), Ni(II), and Cu(II) ions with Bis-N,N'(salicylidene)-1,3-diaminopropane (LH2), Bis-N,N'(salicylidene)-2,2'-dimethyl-1,3diaminopropane (LDMH2), N(salicylidene)-2-hydroxyaniline (SAP), and Tris-N,N',N''(salicylidene)-2,2',2''-aminoethylamine (Trensal) were prepared and ionized with 30-110 eV electrons in direct inlet (DI). Compounds with metal-oxygen covalent bonds were observed to give molecular peaks, whereas polynuclear complexes containing coordinative bonds did not have such peaks. It was concluded that the coordinative bonds were dissociated by electron impact (EI). The thermogravimetric analysis reveals that the molecular peak observed for the mononuclear complexes which are stable up to 300 °C is also the base peak. The peaks obtained for the di-and trinuclear complexes that decomposed at these temperatures could not be observed as a molecular signal. The resulting fragments were evaluated and compared with the literature data.
“…Mass spectrometry has become increasingly popular in the characterization of coordination compounds due to the development of soft ionization methods over the last two decades. However, most of these studies have been carried out with atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), and especially electrospray ionization (ESI) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The studies performed by classical ionization methods are very limited [16,[21][22][23][24][25].…”
Mono-, di-and trinuclear complexes of Fe(III), Co(II), Ni(II), and Cu(II) ions with Bis-N,N'(salicylidene)-1,3-diaminopropane (LH2), Bis-N,N'(salicylidene)-2,2'-dimethyl-1,3diaminopropane (LDMH2), N(salicylidene)-2-hydroxyaniline (SAP), and Tris-N,N',N''(salicylidene)-2,2',2''-aminoethylamine (Trensal) were prepared and ionized with 30-110 eV electrons in direct inlet (DI). Compounds with metal-oxygen covalent bonds were observed to give molecular peaks, whereas polynuclear complexes containing coordinative bonds did not have such peaks. It was concluded that the coordinative bonds were dissociated by electron impact (EI). The thermogravimetric analysis reveals that the molecular peak observed for the mononuclear complexes which are stable up to 300 °C is also the base peak. The peaks obtained for the di-and trinuclear complexes that decomposed at these temperatures could not be observed as a molecular signal. The resulting fragments were evaluated and compared with the literature data.
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