Antiproliferative effects of sea buckthorn (Hippophae rhamnoides L.) extracts on human colon and liver cancer cell lines

Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.)

“…Among the extracts, the ethyl-acetate soluble extract showed the strongest antiproliferative effects on Caco-2 cells. Phytochemical analysis showed that ursolic acid was much higher in this extract than the others (Grey et al, 2010). Induction of apoptotic activity and apoptotic morphological changes of the nucleus, including chromatin condensation were also observed in the HL-60 cells treated with some of the flavonols isolated from SBT such as quercetin, kaempherol and myricetin (Hibasami et al, 2005).…”

Botanical Antioxidants for Skin Health in the World of Cosmeceuticals

“…More than 200 bioactive components have been found in SBT plant, containing several chemical compounds including carotenoids, tocopherols, sterols, flavonoids, phenolics, lipids, and ascorbic acid. These compounds are of interest due to their biological and therapeutic activities including antioxidant and antiproliferative effects, hepatoprotective effects, antimicrobial effects and immunomodulation effects (Cheng et al, 2003;Christaki et al, 2012;Geetha et al, 2008;Grey et al, 2010;Nemtanu et al, 2009). …”

Ursolic Acid and Other Pentacyclic Triterpenoids: Anticancer Activities and Occurrence in Berries

“…A recent study examined the comparative activities of sea buckthorn berry extracts having varying compositions against cell proliferation in the Caco-2 (colon) and Hep G2 (liver) cancer cell lines (Grey et al, 2010). Among the extracts, the ethyl-acetate soluble extract showed the strongest antiproliferative effects on Caco-2 cells.…”

“…The antiproliferative activity of the ursolic-acid containing fraction was somewhat weaker in the HepG2 cell line, with polyphenolics-rich ethanol-soluble extract showing greater activity. The authors suggest that synergistic effects between the constituents are possible (Grey et al, 2010).…”