Antiproliferative effects of pinostrobin and 5,6-dehydrokavain isolated from leaves of Alpinia zerumbet

Junior, Walter Antônio Roman; Gomes, Denise B.; Zanchet, Barbara; Schönell, Amanda P.; Diel, Kriptsan Abdon Poletto; Banzato, Thais Petrochelli; Ruiz, Ana Lúcia T. G.; Carvalho, João Ernesto de; Neppel, Angelita; Barison, Andersson; Santos, Cid Aimbiré de Moraes

doi:10.1016/j.bjp.2017.05.007

Cited by 34 publications

(42 citation statements)

References 43 publications

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“…Stock cultures were grown according to Roman Junior et al [56] and the attenuated ZIKV (1.18 × 10 9 OMV mL −1 ) was prepared directly diluted in the complete medium, affording the final concentrations of 0.59, 5.9, 59 and 590 × 10 6 OMV mL −1 . Doxorubicin (final concentrations of 0.025, 0.25, 2.5 and 25 μg mL −1 in complete medium) was used as positive control.…”

Section: In Vitro Antiproliferative Assaymentioning

confidence: 99%

Metabolic alterations induced by attenuated Zika virus in glioblastoma cells

et al. 2018

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Background: Zika virus (ZIKV) has recently become a major matter of concern since its association with microcephaly cases in newborns was determined. From then on, ZIKV has been untiringly studied, and several scientific data have shown the virus' tropism to neural cells. Previous studies have proposed that ZIKV induced glioblastoma cells death, suggesting that ZIKV and ZIKV-associated molecules might induce intracellular biochemical alterations, and thereby be alternatives for neural cancer management. In this sense, the present contribution presents a prospective approach for glioblastomas management: producing a ZIKV-based therapy that stimulates glioblastoma control. We developed an attenuated ZIKV prototype based on bacterial outer membrane vesicles (OMV). The attenuated ZIKV was applied on glioblastoma cells, where cytopathic and cytostatic effects were evaluated. Glioblastoma cells, with and without treatment, were submitted to mass spectrometry analysis. Results: Microscopic analysis showed cytopathic effects induced by ZIKV prototype on glioblastoma cells after 24 and 48 h post-treatment. DNA fragmentation assay and TNF-alpha expression were indicative that ZVp induced cell damage and death. The metabolomics investigation elected 5 different biomarkers that might be associated with cell cytopathic effects, highlighting intracellular biochemical modifications induced by the attenuated ZIKV. The remarkable evidence of cell death in glioblastoma stimulated further studies that rendered a preliminary screening with other tumor cell lineages, though anti-proliferative activity test. Among the 11 tumors evaluated, prostate and ovarian tumors were the most affected by ZIKV prototype, and other 6 cell lines also presented cytostatic effects. Conclusions: Results ultimately demonstrated that this prototype not only emerges as a potential alternative for glioblastoma management, but may also be an important tool against other important tumors.

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Section: In Vitro Antiproliferative Assaymentioning

confidence: 99%

Metabolic alterations induced by attenuated Zika virus in glioblastoma cells

et al. 2018

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“…Within the included publications, a total of 26 different cancers were assessed across the 32 studies solely on epithelial malignancies, 6 on mesenchymal malignancies and one study including both. 44 A single publication analysed the effect of the Kava constituent FKB in ectodermal-epithelial cancers, particularly oral squamous cell carcinoma and melanoma. 25 In contrast, the study of mesodermal-epithelial cancers and Kava constituents has been moderately established, particularly in colorectal and breast cancers.…”

Section: Discussionmentioning

confidence: 99%

“…25 In contrast, the study of mesodermal-epithelial cancers and Kava constituents has been moderately established, particularly in colorectal and breast cancers. [17][18][19]21,26,29,40,41,44,48 Malignant epithelial lines studied may have potential mechanistic correlations in OSCC.…”

Section: Discussionmentioning

confidence: 99%

“…Mesenchymal cancer studies were the least investigated with primary focus on leukaemia. 24,44,49 Consideration can be given, however, to their potential application in the context of epithelial-…”

Section: Discussionmentioning

confidence: 99%

“…DMY demonstrated a highly selective antiproliferative effect in ovarian cancer and lung cancer. 44 In contrast, one study found that DMY concentrations of 5-20 μg/mL did not have any effect on human squamous cell carcinoma of the cervix. 32 Finally, a study reported that DMY showed 100-300 times less NF-κB inhibitory activity than methysticin.…”

Section: Desmethoxyyangonin (Dmy) (Also Known As 56-dihydrokavain)mentioning

confidence: 92%

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The protective effects of Kava (Piper Methysticum) constituents in cancers: A systematic review

Celentano

Tran

Testa

et al. 2019

J Oral Pathology Medicine

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Background Kava is a beverage made from the ground roots of the plant Piper Methysticum and has long‐held a significant place within Pacific island communities. Active compounds were extracted from kava, and secondary metabolites include kavalactones, chalcones, cinnamic acid derivatives and flavanones. It is thought that components of kava may exert an antiproliferative effect through cell cycle arrest and promotion of apoptosis. Methods We conducted a systematic review to summarize available evidence of the anticancer effects of kava components and investigate their potential use for oral squamous cell carcinoma (OSCC) treatment. Eligible studies were identified through a comprehensive search of OVID EMBASE, OVID MEDLINE and Web of Science, as at April 2018. Results Of 39 papers that met the inclusion criteria, 32 included in vitro models and 13 included animal studies. A total of 26 different cancers were assessed with 32 studies solely assessing epithelial cancers, 6 mesenchymal cancers and 1 study including both. There was only one report assessing an OSCC cell line. Antiproliferative properties were demonstrated in 32 out of 39 papers. The most researched constituent of kava was flavokavain B followed by flavokavain A. Both were associated with increased expression of pro‐apoptotic proteins and decreased expression of anti‐apoptotic proteins. Further, they were associated with a dose‐dependent reduction of angiogenesis. Conclusion There was heterogeneity of study models and methods of investigation across the studies identified. Components of kava appear to present an area of interest with chemotherapeutic potential in cancer prevention and treatment, particularly for epithelial neoplasms. To date, there is a paucity of literature of the utility of kava components in the prevention and treatment of oral squamous cell carcinoma.

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A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges

Pasdaran,

Grice,

Hamedi

2024

Drug Development Research

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In 2021, the World Health Organization released the fifth edition of the central nervous system (CNS) tumor classification. This classification uses histopathology and molecular pathogenesis to group tumors into more biologically and molecularly defined entities. The prognosis of brain cancer, particularly malignant tumors, has remained poor worldwide, approximately 308,102 new cases of brain and other CNS tumors were diagnosed in the year 2020, with an estimated 251,329 deaths. The cost and time‐consuming nature of studies to find new anticancer agents makes it necessary to have well‐designed studies. In the present study, the pathways that can be targeted for drug development are discussed in detail. Some of the important cellular origins, signaling, and pathways involved in the efficacy of bioactive molecules against CNS tumorigenesis or progression, as well as prognosis and common approaches for treatment of different types of brain tumors, are reviewed. Moreover, different study tools, including cell lines, in vitro, in vivo, and clinical trial challenges, are discussed. In addition, in this article, natural products as one of the most important sources for finding new chemotherapeutics were reviewed and over 700 reported molecules with efficacy against CNS cancer cells are gathered and classified according to their structure. Based on the clinical trials that have been registered, very few of these natural or semi‐synthetic derivatives have been studied in humans. The review can help researchers understand the involved mechanisms and design new goal‐oriented studies for drug development against CNS malignancies.

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Antiproliferative effects of pinostrobin and 5,6-dehydrokavain isolated from leaves of Alpinia zerumbet

Cited by 34 publications

References 43 publications

Metabolic alterations induced by attenuated Zika virus in glioblastoma cells

Metabolic alterations induced by attenuated Zika virus in glioblastoma cells

The protective effects of Kava (Piper Methysticum) constituents in cancers: A systematic review

A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges

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