Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines

Kandile, Nadia G.; Mohamed, Mohamed Bakr; Ismaeel, Hind M.

doi:10.3109/14756366.2011.588950

Cited by 11 publications

(9 citation statements)

References 12 publications

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“…Isatin was Erst synthetically obtained as an oxidation product of indigo in the early 19th century by Erdman and Laurent 8 . The synthetic interest in the chemistry of isatin and its derivatives stemmed from its easy synthetic accessibility and exhibition of broad spectrum biological effects, including antibacterial, antifungal, anticonvulsant, antiviral, anticancer, antioxidant, anti-inflammatory and antiproliferative activities [9][10][11][12][13][14][15][16] . Isatin derivatives, such as hydrazones, Schiff's and Mannich bases are of great medicinal value owing to their numerous chemotherapeutic properties [17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids

Sharma

Balwani

Mathur

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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New isatin-triazole based hybrids have been synthesized and evaluated for their inhibitory activity of TNF-a induced expression of Intercellular Adhesion Molecule-1 (ICAM-1) on the surface of human endothelial cells. Structure-activity relationship (SAR) studies revealed that the presence of the electron-attracting bromo substituent at position-5 of the isatin moiety played an important role in enhancing the anti-inflammatory potential of the synthesized compounds. Z-1-[3-(1H-1,2,4-Triazol-1-yl)propyl]-5-bromo-3-[2-(4-methoxyphenyl)-hydrazono]indolin-2-one (19) with an IC 50 ¼ 20 mM and 89% ICAM-1 inhibition with MTD at 200 mM was found to be the most potent of all the synthesized derivatives. Introduction of 1,2,4-triazole ring and electron-donating methoxy group on the phenylhydrazone moiety resulted in four-fold increase of the anti-inflammatory activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids

Sharma

Balwani

Mathur

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…By evaluating the complexes using the brine shrimp bioassay, the Cu(II) complex 52d displayed the highest cytotoxicity with LD 50 value of 156 nM[78].Compounds 53a and 53b were examples of 3-hydrazinoindolin-2-one derivatives in which the terminal N is directly attached to heterocyclic ring (Figure 34). They possessed potent cytotoxic effect against HCT-116 cell line (53a; IC 50 = 0.94 µg/mL and 53b; IC 50 = 0.69 µg/mL) and MCF-7 cell line (53a; IC 50 = 0.54 µg/mL and 53b; IC 50 = 0.74 µg/mL)[79].…”

mentioning

confidence: 99%

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

Ibrahim

Abou‐Seri

Abdel‐Aziz

2016

European Journal of Medicinal Chemistry

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“…Microwave technology is particularly suitable for the rapid and automated production of heterocyclic libraries [24][25][26][27][28][29][30] . In this study, we have synthesized hydrazine derivatives and three different classes of bis-Schiff bases.…”

Section: Chemistrymentioning

confidence: 99%

“…Hence it was considered that combinations of indole and 1,2,4-triazole structures might provide more potent pesticides 23 . In continuation of our studies on the synthesis and evaluation of biological activity of new heterocycles [24][25][26][27][28][29][30] , we report herein the efficient synthesis of new hydrazones, and Schiff bases based on the indole moiety and the evaluation of their biological activity as antimicrobial and anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis andin vitrobiological evaluation of new heterocycles based on the indole moiety

Kandile

Mohamed

Ismaeel

2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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New compounds based on the indole moiety were synthesized via the reaction of indole-3-carbinal 1 with different nucleophiles such as 6-aryl-[4-(2-methoxybenzyl)pyridazin-3-yl] hydrazones 2a-c, benzidine, 3,3 0 -dimethoxybenzidine 4a,b and 2,6-diaminopyridine 6 to afford hydrazine derivatives 3a-c and three different classes of bis-Schiff bases. The structures of the new compounds were elucidated on the basis of their FTIR, 1 H NMR, 13C NMR spectral data, GC/MS and elemental analysis. The antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four pathogenic bacteria and two pathogenic fungi strains. Compound 14b showed excellent activity against Escherichia coli and Klebsiella pneumoniae. Some of the prepared compounds were tested for anti-cancer activity against human cell lines HCT116 (colon), MCF7 (breast) and HELA (cervix). From the results of the in vitro assays, compounds 3a,b, and 18a,c presented promising anti-cancer activity.

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Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines

Cited by 11 publications

References 12 publications

Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids

Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

Synthesis andin vitrobiological evaluation of new heterocycles based on the indole moiety

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