Antiproliferative effects of Evernic acid on A549 and healthy human cells: An in vitro study

Lichen Depsides and Tridepsides: Progress in Pharmacological Approaches

“…Contrary to these data, evernic acid demonstrated strong cytotoxic activity at 25 and 50 µg/mL concentrations in a HeLa cell line and a reduction in A549 cancer cell proliferation (at 12.5, 25, 50, and 100 µg/mL). These depside concentrations were studied in healthy HUVEC cells with no toxic results, making this a good candidate for cancer treatment [ 90 , 91 ]. Evernic acid was also investigated against glioblastoma multiforme (GBM) cancer using A-172 and T98G cells, with moderate activity in A-172 cultures (IC 50 33.2 µg/mL).…”

Antigenotoxic and Antioxidant Activity of Lichens Anaptychia ciliaris, Bryoria fuscescens, Parmotrema chinensa and Xanthoria candelaria: An in vitro Study

“…A number of factors such as specific and extreme habitat, slow growth and long life are the basis for the production of diverse bioactive compounds having protective functions against several physical and biological influences [6][7][8]. They have been attracting the attention of many researchers because of their diverse pharmaceutical potentials as shown in their antioxidant [9,10], antiviral [11], anti-proliferative [12,13], anti-inflammatory, anti-tumor [14][15][16], and insecticidal [17] activities. Also, lichens are considered to be a source of natural antioxidants [18,19].…”