2008
DOI: 10.1016/j.bmcl.2007.11.082
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Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells

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Cited by 85 publications
(58 citation statements)
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“…Schizandrin B and C are components of SC extract (Xu et al, 2011). Schizandrin B has been used to treat vascular injury (Chiu et al, 2004;Kim et al, 2011;Park et al, 2012) and schizandrin C has been reported to induce leukemia cell death (Park et al, 2009), and the deaths of human cancer cell lines (Min et al, 2008;Yasukawa et al, 1992). However, the underlying pharmacological mechanisms of SC extract are not clearly understood.…”
Section: Introductionmentioning
confidence: 99%
“…Schizandrin B and C are components of SC extract (Xu et al, 2011). Schizandrin B has been used to treat vascular injury (Chiu et al, 2004;Kim et al, 2011;Park et al, 2012) and schizandrin C has been reported to induce leukemia cell death (Park et al, 2009), and the deaths of human cancer cell lines (Min et al, 2008;Yasukawa et al, 1992). However, the underlying pharmacological mechanisms of SC extract are not clearly understood.…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have demonstrated the diverse pharmacological activities of S. chinensis, which include anti-oxidant, anti-tumor, anti-obesity, anti-inflammatory, and cardioprotective effects. [11][12][13][14][15] In addition, hepatoprotective activities of S. chinensis have also been reported. [16][17][18][19] A recent study of ours showed that S. chinensis has a protective effect against ER stress-induced hepatic steatosis (unpublished data).…”
mentioning
confidence: 99%
“…More than 40 pharmacologically active lignans have been isolated from the fruit of S. chinensis (15)(16)(17)(18)(19)(20). The major lignans in S. chinensis are schisandrin, schisandrin B, schisandrin C, isoschizandrin, deoxyschisandrin, gomisin A, gomisin N and wuweizisu C, and there have been shown to exert a wide array of pharmacological and biological activities including anti-cancer effects (18,(22)(23)(24)(25)(26)31). However, the precise mechanism of schisandrin C-mediated cell growth inhibition is unclear.…”
Section: Discussionmentioning
confidence: 99%
“…The seeds and fruits of S. chinensis are enriched in lignans, and more than 40 lignans have been isolated from this plant (15)(16)(17)(18)(19)(20)(21). Some lignans have previously been reported to induce cell cycle arrest and apoptosis in human cancer cell lines including leukemia cells (22)(23)(24)(25)(26). However, the underlying molecular mechanisms for their putative therapeutic effects are not clear.…”
Section: Introductionmentioning
confidence: 99%