Antiproliferative effect of saffron and its constituents on different cancerous cell lines

Bukhari, Syed Imran; Din, Inshah; Grewal, Simmi; Dhar, Manoj K.

doi:10.4103/pr.pr_124_17

Cited by 8 publications

(3 citation statements)

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“…Saffron is attractive as a functional food due to its potential beneficial effects on different human cancers and its chemopreventive properties [ 17 ]. Saffron is currently recognized for its antitumor properties, and its cytotoxic effect has been studied in different cancer cell lines [ 18 ] including the A549 lung cancer cell line [ 19 ]. The A549 cell line consists of hypotriploid alveolar basal epithelial cells and is the most used human lung cancer cell line for both basic research and drug discovery [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

et al. 2021

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Despite the beneficial health properties shown by Lebanese saffron, its qualitative and quantitative composition has never been investigated before. In the present study, NMR spectroscopy, together with antioxidant activity assays, were applied to evaluate the chemical composition of saffron samples of different geographical origins (Lebanon, Italy, Iran, and India) and to categorize the Lebanese saffron for the first time. The distinction between Lebanese saffron and that produced in other countries was attributed to its higher linolenic and linoleic fatty acids, glucose and picrocrocin contents. Moreover, spices produced in three different regions of the Lebanese territory have been clearly differentiated. Saffron cultivated in the Qaa region displayed a high glucose, fatty acids and polyphenols content, whereas Hermel saffron exhibited the largest rate of picrocrocin and glycosylated carotenoids. Finally, samples from Baalbeck showed lower rates for the majority of metabolites. Moreover, Lebanese saffron showed a high antioxidant activity in ABTS and DPPH assays. A low dose of saffron extract (10 µg/mL) inhibited the growth of human lung adenocarcinoma cells, probably due to the high polyphenolic content. This study highlights the quality and peculiarity of Lebanese saffron cultivated in Northern Beqaa district and allows for a good discrimination between spices produced in relatively close territory.

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Section: Introductionmentioning

confidence: 99%

1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

et al. 2021

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“…Saffron crocin and safranal have been studied for their ability to reduce cellular proliferation in different models including lung (A549), colon (HCT-116), breast (T47d), and prostate (PC-3) cancer cell lines [63]. For this reason, to test whether the saffron extract obtained from our cell suspension can reproduce this biological action in vitro, we determined the effects on a breast cancer human cell line.…”

Section: Discussionmentioning

confidence: 99%

Salycilic Acid Induces Exudation of Crocin and Phenolics in Saffron Suspension-Cultured Cells

Moradi

Zarinkamar

Domenico

et al. 2020

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The production of crocin, an uncommon and valuable apocarotenoid with strong biological activity, was obtained in a cell suspension culture of saffron (Crocus sativus L.) established from style-derived calli to obtain an in-vitro system for metabolite production. Salycilic acid (SA) was used at different concentrations to elicit metabolite production, and its effect was analyzed after a 4 days of treatment. HPLC-DAD analysis was used for total crocin quantification while the Folin-Ciocâlteu method was applied for phenolic compounds (PC) content. Interestingly, despite cell growth inhibition, a considerable exudation was observed when the highest SA concentration was applied, leading to a 7-fold enhanced production of crocin and a 4-fold increase of phenolics compared to mock cells. The maximum antioxidant activity of cell extracts was evidenced after SA 0.1 mM elicitation. Water-soluble extracts of saffron cells at concentrations of 1, 0.5, and 0.1 µg mL−1 showed significant inhibitory effects on MDA-MB-231 cancer cell viability. The heterologous vacuolar markers RFP-SYP51, GFPgl133Chi, and AleuRFP, were transiently expressed in protoplasts derived from the saffron cell suspensions, revealing that SA application caused a rapid stress effect, leading to cell death. Cell suspension elicitation with SA on the 7th day of the cell growth cycle and 24 h harvest time was optimized to exploit these cells for the highest increase of metabolite production in saffron cells.

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“…In a concentration-dependent manner, both safranal and crocin reduced cell proliferation in all malignant cell lines. IC50 values ranged from 0.32 to 0.42 mM for safranal, 0.31 to 0.92 mM for crocin, and 0.58 to 0.98 mg/mL for Crocus sativus L. extract (Bukhari et al, 2018). Based on the findings of this study, although the cell lines we used in our experimental study are different, saffron has an effect on cell lines, suggesting that saffron can be used as a promising chemotherapeutic agent in the treatment of cancer in the future.…”

Section: Figure 2 Percent % Viability Values Of Mcf-7 and Mcf-12a Cel...mentioning

confidence: 99%

Determination of the saffron on MCF-7 and MCF-12a cell lines

KESKİNER

Kocaman

2023

Sabuncuoglu Serefeddin Health Sciences

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Cancer is recognized as a major threat to health in the world, where response to treatment varies. Recently, there has been a great interest in the inhibitory role of herbs and spices in tumor growth inhibition and cancer progression. Saffron, also called 'red gold', is an aromatic medicinal herb. Saffron's medicinal virtues, ease of use in the kitchen, and its phytochemical profile have led to further investigation of its biological and therapeutic properties. Saffron is rich in carotenoids. Many studies have investigated the effect of saffron and its active ingredients in the prevention and treatment of cancer. Today, the mechanism of action of saffron has not yet been clarified. The aim of this study was to determine the anticancer and antitoxic effects of saffron as a chemo-inhibitory herb in MCF-7 and MCF-12a cell lines, respectively.

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Antiproliferative effect of saffron and its constituents on different cancerous cell lines

Cited by 8 publications

References 0 publications

1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

Salycilic Acid Induces Exudation of Crocin and Phenolics in Saffron Suspension-Cultured Cells

Determination of the saffron on MCF-7 and MCF-12a cell lines

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