Antiproliferative effect of quercetin in the human U138MG glioma cell line

Abstract

Recent epidemiological and dietary intervention studies in animals and humans have suggested that diet-derived flavonoids, in particular quercetin, may play a beneficial role by preventing or inhibiting tumorigenesis. The aim of this study was to evaluate whether quercetin may act differently on cancer and normal neuronal tissue. In order to investigate this, the U138MG human glioma cell line and hippocampal organotypic cultures were used. The study showed that quercetin induced in glioma cell cultures results in (a) a decrease in cell proliferation and viability, (b) necrotic and apoptotic cell death, (c) arrest in the G2 checkpoint of the cell cycle, and (d) a decrease of the mitotic index. Furthermore, we demonstrated that while quercetin promotes cancer regression it was able to protect the hippocampal organotypic cultures from ischemic damage. To sum up, our results suggest that quercetin induced growth inhibition and cell death in the U138MG human glioma cell line, while exerting a cytoprotective effect in normal cell cultures.

Novel Therapeutic Venues for Glioblastoma: Novel Rising Preclinical Treatment Opportunities

“…Quercetin led to a G2 cell-cyle arrest accompanied by a reduction of mitotic rate (Braganhol, Zamin et al, 2006). In addition, this group was able to show that ischemic damage to hippocampal slice cultures was attenuated by quercetin (Braganhol, Zamin et al, 2006). These results are in so far exciting as quercetin obviously exerts anti-cancer effects on one of the most highly therapeutic resistant tumor, glioblastoma, while at the same concentrations it exhibits neuro-protection to oxygen-sensitive hippocampal neuronal cells.…”

“…Quercetin led to a G2 cell-cyle arrest accompanied by a reduction of mitotic rate (Braganhol, Zamin et al, 2006). In addition, this group was able to show that ischemic damage to hippocampal slice cultures was attenuated by quercetin (Braganhol, Zamin et al, 2006).…”

“…showed that quercetin has anti-proliferative effects on U138 glioma cells (Braganhol, Zamin et al, 2006). Quercetin led to a G2 cell-cyle arrest accompanied by a reduction of mitotic rate (Braganhol, Zamin et al, 2006).…”

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

“…It has been reported that quercetin in low concentration promoted cell proliferation of A-549 cells, whereas in higher concentration it inhibited cell proliferation and survival [43]. Further quercetin exerted antiproliferative effect against glioma and breast cancer cells [44][45][46]. Acacetin, another important flavanoid inhibited the proliferation of A549 cells, induced apoptosis and blocked the cell cycle progression at G1 phase.…”

Effect of Rosehip (<i>Rosa Canina</i>) Extracts on Human Brain Tumor Cell Proliferation and Apoptosis

“…Recent studies have investigated the anti-oncogenic properties of natural products and several of these studies have shown that natural product extracts exhibit anti-oncogenic properties against various types of cancer [3][4][5][6][7]. Specifically, there has been a renewed effort to examine the anti-oncogenic properties of natural products for the treatment of GBM cells [8][9][10][11][12][13]. However, the anti-oncogenic properties of rosehip extracts on GBM cells have not been widely investigated.…”