Antiproliferative effect of peptide fractions isolated from a quality protein maize, a white hybrid maize, and their derived peptides on hepatocarcinoma human HepG2 cells

Ortiz‐Martínez, Margarita; Mejía, Elvira González de; García‐Lara, Silverio; Aguilar, Oscar; López-Castillo, Laura Margarita; Otero-Pappatheodorou, José T.

doi:10.1016/j.jff.2017.04.015

Cited by 45 publications

(38 citation statements)

References 72 publications

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“…For example, CPs was subsequently purified by gel filtration chromatography pretreated by alkaline protease and Flavorzyme to yield CPs (Zhuang et al., ). Antiproliferative CPs can be isolated and purified by anion exchange chromatography with FPLC equipment (Ortiz‐Martinez et al., ). A novel antihypertensive dipeptide (Ala‐Tyr) was isolated from CGM using Bio‐Rad P‐2 gel filtration and RP‐HPLC (Yang, Tao, Liu, & Liu, ).…”

Section: Production Isolation Purification and Characterization Ofmentioning

confidence: 99%

“…Ortiz‐Martinez et al. () revealed the anti‐proliferative ability of CPs in HepG2 cells based on decreasing the expressions of anti‐apoptotic factors such as livin, survivin, cellular inhibitor of apoptosis protein (cIAP), X‐linked inhibitor of apoptosis protein (XIAP), and hypoxia‐inducible factor 1α (HIF‐1α). Díaz‐Gómez, Ortíz‐Martínez, Aguilar, García‐Lara, and Castorena‐Torres () have also demonstrated that CPs induced apoptosis of HepG2 cells via increasing the expression of caspase‐3.…”

Section: Biological Activities and Corresponding Mechanisms Of Bioactmentioning

confidence: 99%

“…CPs, increasingly isolated from CGM and characterized as small in size, safe for consumption, and easily absorbable, have been reported to have many potential bioactive properties such as antioxidant (Zhou et al., ), antihypertensive (Huang, Sun, He, Dong, & Li, ), hepatoprotective (Wu et al., ), alcohol‐metabolism‐facilitating (Yu, Li, He, Huang, & Zhang, ), anti‐inflammatory (Mochizuki, Shigemura, & Hasegawa, ), anticancer (Ortiz‐Martinez et al., ), antimicrobial (Liang, Chalamaiah, Ren, Ma, & Wu, ), and DPP‐IV (EC 3.4.14.5) inhibitory activities (Hira, Mochida, Miyashita, & Hara, ).…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

Zhu

Hou

2018

Comp Rev Food Sci Food Safe

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Bioactive peptides are specific peptide fragments that positively exert various functional and biological activities and ultimately influence health. Corn protein are potential precursor proteins for bioactive peptides. This review encompasses the studies reported to date on the production, isolation, purification, and characterization technologies of bioactive corn peptides (CPs), with particular attention being devoted to these peptides’ different health effects, including antioxidant, antihypertensive, hepatoprotective, alcohol‐metabolism‐facilitating, anti‐inflammatory, anticancer, antimicrobial, and dipeptidyl peptidase IV (DPP‐IV) inhibitory activities. The review also describes studies examining the potential mechanisms believed to be involved in these bioactivities, and the possible absorption and transport pathways of CPs are summarized.

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Section: Production Isolation Purification and Characterization Ofmentioning

confidence: 99%

Section: Biological Activities and Corresponding Mechanisms Of Bioactmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

Zhu

Hou

2018

Comp Rev Food Sci Food Safe

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“…The potential therapeutic use of peptides derived from food has been discussed previously (Malaguti et al, 2014; Ortiz-Martinez et al, 2014), and these peptides have displayed a broad range of effects in different models (McDermott, 2009). The main objective of this review was to report the current status and advances in knowledge regarding the bioactive properties of maize peptides, and to review the evidence relating to the identification, characterization, and relevance of the biological activities through which these peptides exert an anti-cancer effect.…”

Section: Introductionmentioning

confidence: 97%

Anti-Cancer Activity of Maize Bioactive Peptides

et al. 2017

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Cancer is one of the main chronic degenerative diseases worldwide. In recent years, consumption of whole-grain cereals and their derivative food products has been associated with a reduced risk of various types of cancer. The main biomolecules in cereals include proteins, peptides, and amino acids, all of which are present in different quantities within the grain. Some of these peptides possess nutraceutical properties and exert biological effects that promote health and prevent cancer. In this review, we report the current status and advances in knowledge regarding the bioactive properties of maize peptides, such as antioxidant, antihypertensive, hepatoprotective, and anti-tumor activities. We also highlight the potential biological mechanisms through which maize bioactive peptides exert anti-cancer activity. Finally, we analyze and emphasize the potential applications of maize peptides.

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“…Peptides have recently gained significant attention as potential therapeutic agents for treating a plethora of ailments . Over 7000 naturally‐occurring peptides have essential roles in modifying human pathophysiology, falling under groups such as growth factors, anti‐infective agents, hormones, ion channel ligands, and neurotransmitters .…”

Section: Introductionmentioning

confidence: 99%

Bioactive peptides and proteins as alternative antiplatelet drugs

Rengasamy

Khan

Ahmad

et al. 2019

Medicinal Research Reviews

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Antiplatelet drugs reduce the risks associated with atherothrombotic events and show various applications in diverse cardiovascular diseases including myocardial infarctions. Efficacy of the current antiplatelet medicines including aspirin, clopidogrel, prasugrel and ticagrelor, and the glycoprotein IIb/IIIa antagonists, are limited due to their increased risks of bleeding, and antiplatelet drug resistance. Hence, it is important to develop new effective antiplatelet drugs, with fewer side‐effects. The vast repertoire of natural peptides can be explored towards this goal. Proteins and peptides derived from snake venoms and plants represent exciting candidates for the development of novel and potent antiplatelet agents. Consequently, this review discusses multiple peptides that have displayed antiplatelet aggregation activity in preclinical drug development stages. This review also describes the antiplatelet mechanisms of the peptides, emphasizing the signaling pathways intervened by them. Also, the hurdles encountered during the development of peptides into antiplatelet drugs have been listed. Finally, hitherto unexplored peptides with the potential to prevent platelet aggregation are explored.

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Antiproliferative effect of peptide fractions isolated from a quality protein maize, a white hybrid maize, and their derived peptides on hepatocarcinoma human HepG2 cells

Cited by 45 publications

References 72 publications

A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

Anti-Cancer Activity of Maize Bioactive Peptides

Bioactive peptides and proteins as alternative antiplatelet drugs

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