2001
DOI: 10.1248/bpb.24.1443
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Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis.

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Cited by 24 publications
(29 citation statements)
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“…As noted previously, compound 8 was reported to moderately inhibit the proliferation of B16F10 [8], HeLa [8], and MK-1 [8] cells and to be a moderately cytotoxic compound to HepG2 [9] and MRC-5 cells [11]. Compounds 6−10 exhibited significantly lower activity compared to 3,5-digalloyl-(-)-epicatechin (4 (-)-epigallocatechin (10), in which the number of hydroxyl groups on the B-ring was greater than that in 4, did not efficiently inhibit cell proliferation.…”
Section: Inhibitory Activity Against Cervical Epithelioid Carcinoma Csupporting
confidence: 63%
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“…As noted previously, compound 8 was reported to moderately inhibit the proliferation of B16F10 [8], HeLa [8], and MK-1 [8] cells and to be a moderately cytotoxic compound to HepG2 [9] and MRC-5 cells [11]. Compounds 6−10 exhibited significantly lower activity compared to 3,5-digalloyl-(-)-epicatechin (4 (-)-epigallocatechin (10), in which the number of hydroxyl groups on the B-ring was greater than that in 4, did not efficiently inhibit cell proliferation.…”
Section: Inhibitory Activity Against Cervical Epithelioid Carcinoma Csupporting
confidence: 63%
“…Since its first isolation from Sanguisorba officinals [4], there have been several reports regarding the isolation and biological activities of compound 8 as a minor constituent of Paeoniae obovate [7]; a moderate antiproliferation constituent against B16F10 [8], HeLa [8], and MK-1 [8]; a cytotoxic constituent against HepG2 [9] isolated from the seeds of Rhynchosia volubilis; and an antioxidant isolated from Acacia nilotica [10]. In addition, synthesis of 8 from a catechol-protected-(+)-catechin derivative, moderate antiplasmodial activity against FcB1, and cytotoxicity against MRC-5 cells were reported [11].…”
Section: Synthesismentioning
confidence: 99%
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“…For example, gallic acid and its analogs were reported from species such as R. volubilis and R. minima, isovitexin (flavonoid), and 8-C-prenylquercetin 7,4′-dimethyl ether (flavanol) were reported from the leaves of R. cyanosperma along with gallic acid derivatives. [15][16][17] These compounds are biologically important and proven to be active in a considerable number of pharmacological studies. [16][17][18][19] For example, antibacterial biphenyl constituents 4-(3-methyl-but-2-enyl)-5-methoxy-[1,1′ -biphenyl]-3-ol and 2-carboxy-4-(3-methyl-but-2-enyl)-5-methoxy-[1,1′-biphenyl]-3-ol were reported from R. suaveolens.…”
Section: Resultsmentioning
confidence: 99%
“…[15][16][17] These compounds are biologically important and proven to be active in a considerable number of pharmacological studies. [16][17][18][19] For example, antibacterial biphenyl constituents 4-(3-methyl-but-2-enyl)-5-methoxy-[1,1′ -biphenyl]-3-ol and 2-carboxy-4-(3-methyl-but-2-enyl)-5-methoxy-[1,1′-biphenyl]-3-ol were reported from R. suaveolens. 11 Therefore, it would be worth while carrying out a phytochemical investigation of R. scarabaeoides in order to isolate the active constituents responsible for the antibacterial activity found in the present study.…”
Section: Resultsmentioning
confidence: 99%