Antiproliferative, antimicrobial, and antioxidant activity of Lavandula angustifolia Mill. essential oil

Nikšić, Haris; Kovac-Besovic, E; Omeragić, Elma; Šamija, Mirko; Kusturica, Jasna; Durić, Kemal

doi:10.17532/jhsci.2017.412

Cited by 16 publications

(16 citation statements)

References 18 publications

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“…The earliest therapeutic use of L. angustifolia can be traced back to Roman and Greek times [4]. Several experimental studies on L. angustifolia testified its Soporific [5], antispasmodic [6], anticonvulsive (Yamada et al ., 1994), anesthetic (Ghelardini et al, 1999), diuretic [7], antidepressant and anxiolytic [8], dyslipidemia [9], cardioprotective [10], analgesic and anti-inflammatory [11], wound healing [12], insecticidal [13], antiproliferative, antimicrobial, and antioxidant [14] activities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Skin Irritation and Acute and Subacute Oral Toxicity of Lavandula angustifolia Essential Oils in Rabbit and Mice

Mekonnen

Tesfaye

Christos

et al. 2019

Journal of Toxicology

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Lavandula angustifolia is used in traditional and folk medicines of Ankober District, North Central Ethiopia, for the treatment of several livestock and human disorders. This toxicity study aimed to investigate L. angustifolia essential oil oral toxicity in mice and skin irritation in rabbit. L. angustifolia essential oil was analyzed using gas chromatography-mass spectrometry methods and showed predominance of Eucalyptol (52.36%), Camphor (11.91%), gamma-terpinene (8.775%) and endoborneol (7.585%). Limit test at 2000 mg/kg dose was used for L. angustifolia essential oil acute toxicity test and revealed LD50 value was higher than 2000 mg/kg. For subacute toxicity study 2000mg/kg was given orally to each mouse for 21 days. The result demonstrated no significant changes (p > 0.05) in the body weights, and biochemical parameters, gross abnormalities, water, and food intake were observed. No macroscopic changes were seen in the histopathology analysis of kidneys and livers. For skin irritation test shaved rabbit skin was treated with 10% ointment formulation. Ointment of L. angustifolia oil did not affect mice skin. Generally, this toxicity study demonstrated that L. angustifolia essential oil is nontoxic.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Skin Irritation and Acute and Subacute Oral Toxicity of Lavandula angustifolia Essential Oils in Rabbit and Mice

Mekonnen

Tesfaye

Christos

et al. 2019

Journal of Toxicology

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“…This review detailed the main studies on the different essential oils of lavender and obtained a valuable collection on all their pharmacological potential. In this context, the current Research, Society and Development, v. 10, n. 5, e23310514933, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i5.14933 body of literature suggests the lavender essential oil as a very promising substance that has several pharmacological activities such as anti-inflammatory (Cardia et al, 2018), hepatoprotective (Cardia et al, 2021), antidepressant and anxiolytic (Woelk & Schläfke, 2010), cardioprotective (Ziaee et al, 2015), analgesic , wound healing (Mori et al, 2016), antimicrobial and antioxidant (Cardia et al, 2021;Niksic et al, 2017). Thus, with all these properties found in lavender essential oils, new research is important to expand knowledge and use in clinical conditions to determine the therapeutic efficacy of lavender oils.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological, medicinal and toxicological properties of lavender essential oil: A review

Cardia

Silva-Comar

Rocha

et al. 2021

RSD

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The natural products extracted from plants are part of traditional medicine and are also therapeutic possibilities for treating many diseases. Recently, its use in the development of new drugs has shown much visibility for its efficiency and few adverse effects. Essential oils extracted from medicinal plants are indicated to treat numerous diseases due to their antimicrobial, antiviral, antimutagenic, anticancer, antioxidant, anti-inflammatory, immunomodulatory, and antiprotozoal properties. Among essential oils, lavender essential oil stands out for having several important pharmacological properties. This review detailed the main studies on essential oils from different species of lavender and obtained a valuable collection on all their pharmacological, medicinal and toxicological potential. In this context, we evaluated lavender essential oil as a promising substance that can help treat several diseases. We provide some evidence and an overview of the potential therapeutic effect of lavender essential oil to guide new research.

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“…essential oil it is noticed that the M. officinalis L. essential oil has a significantly more potent effect than L. angustifolia essential oil on antiproliferation of tumor cells. L. angustifolia essential oil showed antiproliferative activity to MOLT-4, MCF-7 and NCI-H460 cancer cell lines with GI50 values that are significantly higher than M. officinalis L. essential oil GI50 values (Nikšić et al, 2017. ).…”

Section: Discussionmentioning

confidence: 99%

In vitro antiproliferative activity of Melissa officinalis L (Lamiaceae) leaves essential oil

Nikšić¹,

Durić²,

Sijamic³

et al. 2019

Bol Latinoam Caribe Plant Med Aromat

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In the present study, we investigated the antiproliferative activity of essential oil from leaves of Melissa officinalis L. grown in Southern Bosnia and Herzegovina. In vitro evaluation of antiproliferative activity of the M. officinalis essential oil was carried out on three human tumor cell lines: MCF-7, NCI-H460 and MOLT-4 by MTT assay. M. officinalis essential oil was characterized by high percentage of monoterpenes (77,5%), followed by the sesquiterpene fraction (14,5%) and aliphatic compounds (2,2%). The main constituents of the essential oil of M. officinalis are citral (47,2%), caryophyllene oxide (10,2%), citronellal (5,4%), geraniol (6,6%), geranyl acetate (4,1%) and βcaryophyllene (3,8%). The essential oil showed significant antiproliferative activity against three cancer cell lines, MOLT-4, MCF-7, and NCI-H460 cells, with GI50 values of <5, 6±2 and 31±17 µg/mL, respectively. The results revealed that M. officinalis L. essential oil has a potential as anticancer therapeutic agent.Resumen: En el presente estudio, investigamos la actividad antiproliferativa del aceite esencial de las hojas de Melissa officinalis L. cultivadas en el sur de Bosnia y Herzegovina. La evaluación in vitro de la actividad antiproliferativa del aceite esencial de M. officinalis se llevó a cabo en tres líneas celulares de tumores humanos: MCF-7, NCI-H460 y MOLT-4 utilizando el ensayo de MTT. El aceite esencial de M. officinalis se caracterizó por un alto porcentaje de monoterpenos (77,5%), seguido de la fracción sesquiterpénica (14,5%) y compuestos alifáticos (2,2%). Los principales constituyentes del aceite esencial de M. officinalis fueron citral (47,2%), óxido de cariofileno (10,2%), citronelal (5,4%), geraniol (6,6%), acetato de geranilo (4, 1%), y β-cariofileno (3,8%). El aceite esencial mostró una actividad antiproliferativa significativa contra las líneas celulares de cáncer MOLT-4, MCF-7 y NCI-H460, con valores GI50 de <5, 6±2 y 31±17 µg/mL, respectivamente. Los resultados revelaron que el aceite esencial de M. officinalis L. tiene potencial como agente terapéutico contra el cáncer.Palabras clave: Melissa officinalis L.; Aceite esencial; Agentes antiproliferativos; MOLT-4; MCF-7; NCI-H460 Recibido |

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Antiproliferative, antimicrobial, and antioxidant activity of Lavandula angustifolia Mill. essential oil

Abstract: Introduction:We studied the chemical composition and antimicrobial, antioxidant, and antiproliferative activities of essential oils from flowers of Lavandula angustifolia grown in Southern Bosnia and Herzegovina.

Cited by 16 publications

References 18 publications

Evaluation of Skin Irritation and Acute and Subacute Oral Toxicity of Lavandula angustifolia Essential Oils in Rabbit and Mice

Evaluation of Skin Irritation and Acute and Subacute Oral Toxicity of Lavandula angustifolia Essential Oils in Rabbit and Mice

Pharmacological, medicinal and toxicological properties of lavender essential oil: A review

In vitro antiproliferative activity of Melissa officinalis L (Lamiaceae) leaves essential oil

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