Antiproliferative and cytotoxic activities of C-Geranylated flavonoids from Paulownia tomentosa Steud. Fruit

Molčanová, Lenka; Kauerova, Tereza; Dall’Acqua, Stefano; Maršík, Petr; Kollár, Péter; Šmejkal, Karel

doi:10.1016/j.bioorg.2021.104797

Cited by 7 publications

(9 citation statements)

References 34 publications

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“…It also shows a protective effect on H 2 O 2 -induced injury of HUVECs [ 259 ]. Due to its multiple activities, diplacone seems to be a suitable candidate for wound healing; however, its potential cytotoxic effect on normal cell lines remains to be verified, as it shows activity on cancer cells at low concentrations [ 169 , 172 ].…”

Section: Discussionmentioning

confidence: 99%

Prenylated Flavonoids in Topical Infections and Wound Healing

et al. 2022

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The review presents prenylated flavonoids as potential therapeutic agents for the treatment of topical skin infections and wounds, as they can restore the balance in the wound microenvironment. A thorough two-stage search of scientific papers published between 2000 and 2022 was conducted, with independent assessment of results by two reviewers. The main criteria were an MIC (minimum inhibitory concentration) of up to 32 µg/mL, a microdilution/macrodilution broth method according to CLSI (Clinical and Laboratory Standards Institute) or EUCAST (European Committee on Antimicrobial Susceptibility Testing), pathogens responsible for skin infections, and additional antioxidant, anti-inflammatory, and low cytotoxic effects. A total of 127 structurally diverse flavonoids showed promising antimicrobial activity against pathogens affecting wound healing, predominantly Staphylococcus aureus strains, but only artocarpin, diplacone, isobavachalcone, licochalcone A, sophoraflavanone G, and xanthohumol showed multiple activity, including antimicrobial, antioxidant, and anti-inflammatory along with low cytotoxicity important for wound healing. Although prenylated flavonoids appear to be promising in wound therapy of humans, and also animals, their activity was measured only in vitro and in vivo. Future studies are, therefore, needed to establish rational dosing according to MIC and MBC (minimum bactericidal concentration) values, test potential toxicity to human cells, measure healing kinetics, and consider formulation in smart drug release systems and/or delivery technologies to increase their bioavailability.

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Section: Discussionmentioning

confidence: 99%

Prenylated Flavonoids in Topical Infections and Wound Healing

et al. 2022

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“…In traditional Chinese medicine, extracts from the wood, fruit, and bark were used to treat bronchitis, asthma, and bacterial infections [ 30 ]. P. tomentosa was shown to contain flavonoids, lignans, phenolic glycosides, quinones, terpenoids, phytosterols, and glycerides, as well as phenolic acids (p-hydroxybenzoic, gallic, vanillic, cinnamic, caffeic, and p-coumaric acids) [ 14 , 15 , 16 , 17 , 18 ] [ Table 2 ].…”

Section: The Active Substances Of P Tomentosa —The...mentioning

confidence: 99%

“…C-geranylated flavonoids abundant in P. tomentosa are particularly interesting, as they can be found in a relatively small number of plant families. Examples include mimulone and diplacone [ 13 , 14 ]. Apart from C-geranylated flavonoids, Paulownia trees contain phenolic acids, phenolic glycosides, lignans, quinones, terpenoids, phytosterols, and glycerides [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Examples include mimulone and diplacone [ 13 , 14 ]. Apart from C-geranylated flavonoids, Paulownia trees contain phenolic acids, phenolic glycosides, lignans, quinones, terpenoids, phytosterols, and glycerides [ 14 , 15 , 16 , 17 , 18 ]. They exhibit a wide range of biological activities, including antioxidant, anti-inflammatory, antibacterial, antiviral, neuroprotective, antiproliferative, anti-cancer, cytotoxic, and anti-hyperlipidemic activities ( Figure 1 ) [ 14 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Apart from C-geranylated flavonoids, Paulownia trees contain phenolic acids, phenolic glycosides, lignans, quinones, terpenoids, phytosterols, and glycerides [ 14 , 15 , 16 , 17 , 18 ]. They exhibit a wide range of biological activities, including antioxidant, anti-inflammatory, antibacterial, antiviral, neuroprotective, antiproliferative, anti-cancer, cytotoxic, and anti-hyperlipidemic activities ( Figure 1 ) [ 14 , 19 , 20 , 21 , 22 ]. In China, Paulownia has been used as a traditional herbal medicine in the treatment of inflammatory bronchitis, tonsillitis, gonorrhea, traumatic bleeding, asthma, and hypertension [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Paulownia Organs as Interesting New Sources of Bioactive Compounds

Sławińska

Zając

Olas

2023

IJMS

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Paulownia spp. is a genus of trees in the Paulowniaceae family. It is native to southeastern Asia (especially China), where it has been cultivated for decorative, cultural, and medicinal purposes for over 2000 years. Depending on taxonomic classification, there are 6 to 17 species of Paulownia; P. tomentosa, P. elongata, P. fortunei, and P. catalpifolia are considered the most popular. Nowadays, Paulownia trees are planted in Asia, Europe, North America, and Australia for commercial, medical, and decorative purposes. Lately, growing interest in Paulownia has led to the development of various hybrids, the best-known being Clone in vitro 112, Shan Tong, Sundsu 11, and Cotevisa 2. Paulownia Clone in vitro 112 is an artificially created hybrid of two species of Paulownia: P. elongata and P. fortunei. The present review of selected papers from electronic databases including PubMed, ScienceDirect, and SCOPUS before 15 November 2022 describes the phytochemical characteristics, biological properties, and economic significance of various organs from different Paulownia species and hybrids, including P. tomentosa, P. elongata, P. fortunei, and Paulownia Clone in vitro 112. Many compounds from Paulownia demonstrate various biological activities and are promising candidates for natural preparations; for example, the leaves of Clone in vitro 112 have anti-radical and anticoagulant potential. However, further in vivo studies are needed to clarify the exact mechanism of action of the active substances and their long-term effects.

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Phytochemistry and pharmacology of natural prenylated flavonoids

Wang

Luo

et al. 2023

Arch. Pharm. Res.

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Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoids show a wide range of biological activities, such as anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic, anti-obesity, cardioprotective effects, and anti-osteoclastogenic activities. In recent years, many compounds with significant activity have been discovered with the continuous excavation of the medicinal value of prenylated flavonoids, and have attracted the extensive attention of pharmacologists. This review summarizes recent progress on research into natural active prenylated flavonoids to promote new discoveries of their medicinal value. Supplementary Information The online version contains supplementary material available at 10.1007/s12272-023-01443-4.

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Antiproliferative and cytotoxic activities of C-Geranylated flavonoids from Paulownia tomentosa Steud. Fruit

Cited by 7 publications

References 34 publications

Prenylated Flavonoids in Topical Infections and Wound Healing

Prenylated Flavonoids in Topical Infections and Wound Healing

Paulownia Organs as Interesting New Sources of Bioactive Compounds

Phytochemistry and pharmacology of natural prenylated flavonoids

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