Antiproliferative and Chemopreventive Effects of Adlay Seed on Lung Cancer in Vitro and in Vivo

Abstract

This study examined the effects of different extracts of adlay seed on the growth of human lung cancer cells in vitro and in vivo. The data showed that a methanolic extract, but not a water extract, of adlay seed exerted an antiproliferative effect on A549 lung cancer cells by inducing cell cycle arrest and apoptosis. It was also found that tumor growth in vivo was inhibited by the methanolic extract in a dose-dependent manner. The chemopreventive effect of adlay seed on the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice was also investigated. Groups of mice were pre-fed with different diets, followed by feeding with NNK-containing drinking water for 8 months. The results indicated that feeding with diet containing 30% of powdered adlay seed reduced the number of surface lung tumors by approximately 50%. Taken together, these results indicate that the components of adlay seed exert an anticancer effect in vitro and in vivo and may be useful for the prevention of lung tumorigenesis.

Effects of adlay hull extracts on uterine contraction and Ca2+mobilization in the rat

“…Furthermore, different parts of adlay and different extraction fractions of adlay gave various effects (5, 6, 14 -16, 23, 24, 27). The adlay hull extracts have more biological functions in different study models (5,6,15,16,23,24).…”

Jali (Coix lacryma-jobi L.): Biji, perkecambahan, dan potensinya

“…Secara fitokimia, jali mengandung 4-ketopinoresinol; alpha-coixin; alpha-sitosterol; betasitosterol; coicin; coixan A; coixan B; coixan C; coixenolide; coixlactam; coixol; coixspirolactam A; coixspirolactam B; coixspirolactam C; palmitic acid; stearic acid; oleic acid; linoleic acid; alkohol coniferyl alcohol; ferulic acid; gamma-sitosterol; glukosa; metil dioksindol-3-asetat; myuenolide; palmatate; phytin; kalium klorida, stearat, stigmasterol; syringic acid; syringaresinol; vitamin B1; dan peracetylated yang terbentuk dari glukosa, maltosa, maltotriosa, maltotetraose, dan maltopentaose (Bao et al 2005;Chang et al 2003;Chang et al 2006;Check dan K'Ombut 1995;Chung et al 2010;Dalimartha 2008;Hsia et al 2007;Hsia et al 2006;Kim et al 2004;Koh et al 2009;Kuo et al 2002;Lee et al 2008;Otsuka et al 1988;Shih et al 2004;Sugimoto et al 2001;Yang et al 2008).…”

Natural products and their role in cancer therapy

“…The effect of berberine, a major component with antifungal properties contained in C. Rhizoma, on the lymph node [22][23][24] Interaction with other drugs…”