Antiproliferative and apoptotic effects of probiotic whey dairy beverages in human prostate cell lines

Rosa, Lana S.; Santos, Mariana L.; Abreu, Joel Pimentel de; Balthazar, Celso F.; Rocha, Ramon S.; Silva, Hugo L.A.; Esmerino, Erick A.; Duarte, Maria Carmela K.H.; Pimentel, Tatiana Colombo; Freitas, Mônica Q.; Silva, Márcia C.; Cruz, Adriano G.; Teodoro, Anderson Junger

doi:10.1016/j.foodres.2020.109450

Cited by 37 publications

(12 citation statements)

References 27 publications

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“…The effects of probiotics on the prostate have been rarely examined, with only a few studies in recent years. Several in vitro experiments have shown that treatment of human prostate cancer cells with certain probiotic strains ( L. rhamnosus GG, L. acidophilus La-05, L. casei- 01, and Bifidobacterium animalis Bb-12) strongly induced apoptosis [42] , [43] , indicating the potential of probiotics to suppress prostate cancer. Furthermore, probiotics have been demonstrated to improve prevention of episodes and alleviate symptoms in chronic bacterial prostatitis caused by Enterobacteriaceae [44] .…”

Section: Male Reproductive Microbiomementioning

confidence: 99%

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

Feng

Liu

2022

Computational and Structural Biotechnology Journal

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Section: Male Reproductive Microbiomementioning

confidence: 99%

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

Feng

Liu

2022

Computational and Structural Biotechnology Journal

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“…Importantly, probiotic whey dairy beverages have been demonstrated to induce extensive apoptosis in human prostate cancer cell lines in vitro, regardless of the probiotic strain. However, further animal and human studies are required for precise evaluation of the potential of probiotic whey beverages in the therapy of prostate cancer [119]. Additionally, the impact of dietary preferences and obesity on prostate health is highlighted by Frugé et al who describe the overweight and obese cancer patients to be dysbiotic and manifesting unique microbiome profiles [120].…”

Section: Microbiome Profiling and A Protective Role Of Probiotics In Pca Preventionmentioning

confidence: 99%

Systemic Effects Reflected in Specific Biomarker Patterns Are Instrumental for the Paradigm Change in Prostate Cancer Management: A Strategic Paper

Golubnitschaja

Kubatka

Mazuráková

et al. 2022

Cancers

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Prostate cancer (PCa) is reported as the most common malignancy and second leading cause of death in America. In Europe, PCa is considered the leading type of tumour in 28 European countries. The costs of treating PCa are currently increasing more rapidly than those of any other cancer. Corresponding economic burden is enormous, due to an overtreatment of slowly developing disease on one hand and underestimation/therapy resistance of particularly aggressive PCa subtypes on the other hand. The incidence of metastatic PCa is rapidly increasing that is particularly characteristic for young adults. PCa is a systemic multi-factorial disease resulting from an imbalanced interplay between risks and protective factors. Sub-optimal behavioural patterns, abnormal stress reactions, imbalanced antioxidant defence, systemic ischemia and inflammation, mitochondriopathies, aberrant metabolic pathways, gene methylation and damage to DNA, amongst others, are synergistically involved in pathomechanisms of PCa development and progression. To this end, PCa-relevant systemic effects are reflected in liquid biopsies such as blood patterns which are instrumental for predictive diagnostics, targeted prevention and personalisation of medical services (PPPM / 3P medicine) as a new paradigm in the overall PCa management. This strategic review article highlights systemic effects in prostate cancer development and progression, demonstrates evident challenges in PCa management and provides expert recommendations in the framework of 3P medicine.

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“…The presence of essential amino acids, bioactive peptides, and immunostimulants has given “gutter to gold” status to whey (Smithers, 2008). The fortification of whey with fruit juices, probiotics, prebiotics, and plant‐based bioactive agents has been carried out successfully (Panghal et al, 2009; Rosa et al., 2020; Souza et al., 2019; Seyhan et al., 2016).…”

Section: Functional Beverages: An Insightmentioning

confidence: 99%

Functional beverages: Special focus on anti‐diabetic potential

Gayathry

John

2021

Food Processing Preservation

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In recent years, the concept of functional foods and beverages is fast capturing the world's attention. The market growth of functional foods and beverages has been tremendous over the last decade. The reason can be the increased demand for healthy options of food over medicines. Factors such as convenience to incorporate suitable bioactive substances, comparatively easier processing and handling, along with wide acceptance by the population, make functional beverages the most popular category in the functional foods segment. Diabetes is a chronic metabolic disease which is approaching to be the biggest global epidemic of the twenty‐first century. Due to the increased cost of treatment and probable side effects of the synthetic drugs, the possibility of using natural anti‐diabetic agents have been explored extensively nowadays. Numerous studies are being conducted, and the present review tries to cover novel herbal and fruit/vegetable‐based anti‐diabetic functional beverages, current researches, and limitations. Practical applications The concept of “food itself as medicine” is increasing and hence, the demand for functional foods. Functional beverages are a segment in the functional food industry which is comparatively easier to process, handle, and incorporate bioactive compounds. Beverages are a “go and grab product” and attract consumers’ demand. Diabetes is a chronic metabolic disorder and the huge cost of treatment and management of diabetes is a drive for researchers to find alternatives using natural anti‐diabetic agents like phytochemicals. Extensive studies are underway, and the present review attempts to cover various in vitro studies, in vivo models and clinical trials conducted to prove the hypoglycemic properties of novel herbal and fruit/vegetable‐based functional beverages.

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Antiproliferative and apoptotic effects of probiotic whey dairy beverages in human prostate cell lines

Cited by 37 publications

References 27 publications

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

Systemic Effects Reflected in Specific Biomarker Patterns Are Instrumental for the Paradigm Change in Prostate Cancer Management: A Strategic Paper

Functional beverages: Special focus on anti‐diabetic potential

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