Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety

Synthesis and Structure-Activity Relationship Studies of Hydrazide-Hydrazones as Inhibitors of Laccase from Trametes versicolor

“…The hydrazide-hydrazones which had phenyl or alkyl group near the salicylic hydroxy group caused a weak bathochromic effect. The spectroscopic data were consistent with the data published in the literature [46][47][48][50][51][52][53]. The geometry of the imine CH=N double bond of the aroyl hydrazones has an E configuration, which was proved by crystallographic studies of the imine derivatives of 4-hydroxybenzhydrazide with aldehydes such as 2,3-dimethoxybenzaldehyde [50], 5-bromosalicylaldehyde (2d) [53] and vanillic aldehyde (2g) [52].…”

“…Purity and homogeneity of known compounds were confirmed by measuring their m.p. for 1a [44], 1c [46], 1e [47], 1f [48], 1g [49], 1h-j [50], 2d [49], 2g [51], 4b [89], 4c [90], 6a [60], 6d [91], 6e [57], 6f [92], 7a [93], 7b [56], 7d [61], 7f [62], 8b [94], and 8c [95], or boiling points for 6b [96], 7e [97], FT-IR spectra for 1a [51], 1g [52], 1h-i [50], 2g [51], 1 H-and 13 C-NMR spectra for 1c [46], 1e [47], 1f [48], 1g [46], 1h-j [50], 2c [48], 2d [53] and/or HRMS for 2c [48], and comparing them with literature data. All new hydrazide-hydrazones 1b, 1d, 2a-b, 2e-f, 2h, 3a-g, were fully characterized.…”

Antiproliferative, Cytotoxic, and Apoptotic Effects of New Benzimidazole Derivatives Bearing Hydrazone Moiety

“…The bioactivity of hydrazone moiety was hypothesized that hydrazone was prone to form hydrogen bond with molecular target, and N═C bond was also easy to process addition reaction with the nucleophile groups (such as NH 2 and SH) in the target molecules to enhance its anticancer activity [20][21][22][23]. Because of our interest on potential bioactive benzimidazole derivatives, herein, we synthesized novel benzimidazole-hydrazones with the goal of identifying new compounds as anticancer agents.…”

“…They have an imine group (─C═N─), which plays a significant role in the mechanism of transformation and racemization reaction in biological system. The bioactivity of hydrazone moiety was hypothesized that hydrazone was prone to form hydrogen bond with molecular target, and N═C bond was also easy to process addition reaction with the nucleophile groups (such as NH 2 and SH) in the target molecules to enhance its anticancer activity .…”

Physico-Chemical Optimization and Structure-Activity Relationship Studies of Aldehyde-Derived N-Acylhydrazones: Towards the Improvement of Moderate Metal Chelators as a Strategy Against Metal-Enhanced Aggregopathies

“…) shows the presence of at least two sets of signals, demonstrating that an equilibrium occurs in DMSO-d6. All 10 hydrogens that compose the main set of signals were assigned based on the literature(Angelova et al, 2016) and confirmed using bidimensional spectra (not shown). Characteristic hydrazonic N-H and H-C=N singlets resonate in the expected region, similarly to all N-acylhydrazones described in this project, in 12.34 and 8.66 ppm, respectively.…”