Antiproliferative activity, antioxidant capacity and chemical composition of extracts from the leaves and stem of Chresta sphaerocephala

Costa, Larissa Saito da; Andreazza, Nathalia Luiza; Corrêa, Wallace Ribeiro; Cunha, Inara Pereira da; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de; Schinor, Elisandra Cristina; Dias, Diones Aparecida; Salvador, Marcos José

doi:10.1016/j.bjp.2015.04.005

Cited by 13 publications

(5 citation statements)

References 27 publications

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“…The previously known isolated secondary metabolites were identified as piptocarphol ( 1 ), piptocarphin D ( 2 ), 1,4-dihydroxy-5,8,10,13-tetraacetoxycadin-7 (11)-en-6,12-elide ( 4 ), 13-deacylglaucolide B ( 5 ), hirsutolide ( 7 ), glaucolide B ( 8 ), luteolin ( 9 ), quercetin 3-methyl ether ( 10 ), 8- O -deacetyl-8- O -propanoyl glaucolide B ( 11 ), chrysoeriol ( 12 ), quercetin 3,3′-dimethyl ether ( 13 ), and luteolin 3′,4′-dimethyl ether ( 14 ) . To the best of our knowledge, with the exception of compounds 9 , 12 , and 14 , the other substances are described herein for the first time in the genus Chresta . − Besides the known compounds isolated, the separation afforded two new sesquiterpene lactones ( 3 and 6 ), as described below.…”

Section: Resultsmentioning

confidence: 99%

NF-κB and Angiogenesis Inhibitors from the Aerial Parts of Chresta martii

et al. 2018

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The ethyl acetate extract of the aerial parts of Chresta martii showed significant in vitro NF-κB inhibition. Bioactivity-guided isolation was undertaken using HPLC microfractionation to localize the active compounds. Different zones of the HPLC chromatogram were linked to NF-κB inhibition. In parallel to this HPLC-based activity profiling, HPLC-PDA-ESI-MS and UHPLC-TOF-HRMS were used for the early identification of some of the compounds present in the extract and to get a complete phytochemical overview. The isolation of the compounds was performed by high-speed counter-current chromatography and further semipreparative HPLC. Using this approach, 14 compounds were isolated, two of them being new sesquiterpene lactones. The structures of the isolated compounds were elucidated by spectroscopic methods including UV, ECD, NMR, and HRMS. All isolated compounds were evaluated for their inhibitory activity of NF-κB and angiogenesis, and compound 2 showed promising NF-κB inhibition activity with an IC of 0.7 μM. The isolated compounds 1, 2, 5, 7, and 8 caused a significant reduction in angiogenesis when evaluated by an original 3D in vitro angiogenesis assay.

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Section: Resultsmentioning

confidence: 99%

NF-κB and Angiogenesis Inhibitors from the Aerial Parts of Chresta martii

et al. 2018

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“…For the health-promoting compounds in the leaves, there were also differences among the three tested vegetables. Previous studies have shown that chlorophyll, carotenoids, ascorbic acid, flavonoids and other health-promoting compounds have strong antioxidant capacity in vegetable crops [ 23 , 34 , 35 , 36 , 37 , 38 ], and phenolic compounds are also important antioxidants [ 39 , 40 , 41 ]. Our results suggested that for the content of chlorophyll and carotenoids, the trend was sweet potato > amaranth > malabar spinach.…”

Section: Discussionmentioning

confidence: 99%

Variation in the Main Health-Promoting Compounds and Antioxidant Capacity of Three Leafy Vegetables in Southwest China

et al. 2023

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Malabar spinach (Basella alba), amaranth (Amaranthus tricolor), and sweet potato (Ipomoea batatas) are leafy vegetables found in Southwest China. The variation of chlorophyll, carotenoids, ascorbic acid, total flavonoids, phenolic compounds, and antioxidant capacity was studied in the leaves and stems of the three vegetables. The content of main health-promoting compounds and the antioxidant capacity in the leaves were higher than that in the stems, indicating that the leaves of the three vegetables possess greater nutritional value. The trend of total flavonoids in all three vegetables was similar to the trend of antioxidant capacity, suggesting that the total flavonoids may be the major antioxidants wihin these vegetables. Eight individual phenolic compounds were detected in three different vegetables. The most abundant levels of individual phenolic compounds in the leaves and stems of malabar spinach, amaranth, and sweet potato were 6′-O-feruloyl-d-sucrose (9.04 and 2.03 mg g−1 DW), hydroxyferulic acid (10.14 and 0.73 mg g−1 DW), and isorhamnetin-7-O-glucoside (34.93 and 6.76 mg g−1 DW), respectively. Sweet potato exhibited a higher total and individual phenolic compound content compared to malabar spinach and amaranth. Overall, the results demonstrate that the three leafy vegetables possess high nutritional value, and could be used not only for consumption but also in various other fields, including medicine and chemistry.

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“…11 The beneficial action of its plants has already been proven in inflammatory processes against microorganisms and cancer, among other diseases. 12 The search for new drugs that exhibit action against various types of tumors is one of the most interesting topics in the field of natural product research. 13 In this area, plants are considered very promising, since their derivatives are widely used for cancer control.…”

Section: Introductionmentioning

confidence: 99%

Activity of Brazilian Cerrado Plants in Tumor Cell Lines: A Systematic Review

de Oliveira,

Senger,

de Oliveira

2024

Future Integr Med

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Background and objectives: Medicinal plants have been recognized as a promising alternative treatment against some types of cancer, being rich sources of effective biochemical agents. The aim of this study, therefore, was to gather, through a systematic literature review, articles related to plants from the Brazilian Cerrado biome that have an action on different tumor cells.Methods: Different keywords were used in the search mechanisms of Pubmed, Scielo, Science Direct, Scopus, and Lilacs databases. Of the studies found, titles that did not reflect the purpose of this review, those that did not provide access to the full text, and those that were published before 2005 were excluded. Articles referring to the activity of Cerrado plants in tumor cells published in the last sixteen years were selected, totaling thirty-nine articles. Registration number of this review: #CRD42020205579. Results:The extracts from the studied plants demonstrated significant antiproliferative effects against several tumor cell lines. 39 species of plants were identified belonging to the families:

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Antiproliferative activity, antioxidant capacity and chemical composition of extracts from the leaves and stem of Chresta sphaerocephala

Cited by 13 publications

References 27 publications

NF-κB and Angiogenesis Inhibitors from the Aerial Parts of Chresta martii

NF-κB and Angiogenesis Inhibitors from the Aerial Parts of Chresta martii

Variation in the Main Health-Promoting Compounds and Antioxidant Capacity of Three Leafy Vegetables in Southwest China

Activity of Brazilian Cerrado Plants in Tumor Cell Lines: A Systematic Review

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