Antiplatelet therapy before or after 16 weeks’ gestation for preventing preeclampsia

Roberge, Stéphanie; Demers, Suzanne; Bujold, Emmanuel

doi:10.1016/j.ajog.2017.01.034

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…In particular, certain stress-related biopsychosocial variables were related to preeclampsia, including change in corticotropin releasing hormone and hair cortisol levels measured at 12–21 weeks of pregnancy. Detecting preeclampsia risk early in pregnancy may allow for early intervention using low-dose aspirin prophylaxis [22–24]. Additionally, some notable pathways related to race/ethnicity, such as Hispanic ethnicity being linked to greater levels of pre-gestational diabetes, which in turn is linked to fewer gestational weeks (i.e.…”

Section: Discussionmentioning

confidence: 99%

Using graph learning to understand adverse pregnancy outcomes and stress pathways

et al. 2019

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To identify pathways between stress indicators and adverse pregnancy outcomes, we applied a nonparametric graph-learning algorithm, PC-KCI, to data from an observational prospective cohort study. The Measurement of Maternal Stress study (MOMS) followed 744 women with a singleton intrauterine pregnancy recruited between June 2013 and May 2015. Infant adverse pregnancy outcomes were prematurity (<37 weeks' gestation), infant days spent in hospital after birth, and being small for gestational age (percentile gestational weight at birth). Maternal adverse pregnancy outcomes were pre-eclampsia, gestational diabetes, and gestational hypertension. PC-KCI replicated well-established pathways, such as the relationship between gestational weeks and preterm premature rupture of membranes. PC-KCI also identified previously unobserved pathways to adverse pregnancy outcomes, including 1) a link between hair cortisol levels (at 12–21 weeks of pregnancy) and pre-eclampsia; 2) two pathways to preterm birth depending on race, with one linking Hispanic race, pre-gestational diabetes and gestational weeks, and a second pathway linking black race, hair cortisol, preeclampsia, and gestational weeks; and 3) a relationship between maternal childhood trauma, perceived social stress in adulthood, and low weight for gestational age. Our approach confirmed previous findings and identified previously unobserved pathways to adverse pregnancy outcomes. It presents a method for a global assessment of a clinical problem for further study of possible causal pathways.

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Section: Discussionmentioning

confidence: 99%

Using graph learning to understand adverse pregnancy outcomes and stress pathways

et al. 2019

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“…Increasing evidence suggests that LDA treatment during pregnancy reduces the risk of developing pre-eclampsia [27,28]. However, there is still ongoing debate over the timing and dose of LDA treatment [29].…”

Section: Conclusion and Discussionmentioning

confidence: 99%

The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort

Murtoniemi

Vahlberg

Hämäläinen

et al. 2018

Pregnancy Hypertension

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First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume

Sonek

Krantz

Carmichael

et al. 2018

American Journal of Obstetrics and Gynecology

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Antiplatelet therapy before or after 16 weeks’ gestation for preventing preeclampsia

Cited by 7 publications

References 6 publications

Using graph learning to understand adverse pregnancy outcomes and stress pathways

Using graph learning to understand adverse pregnancy outcomes and stress pathways

The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort

First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume

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