Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives

Cunha, Anna C.; Figueiredo, Juliana M.; Tributino, Jorge Luiz Mendonça; Miranda, Ana Luísa P.; Castro, Helena C.; Zingali, Russolina B.; Fraga, Carlos A.M.; Souza, Maria Cecília B. V. de; Ferreira, Vı́tor F.; Barreiro, Eliezer J.

doi:10.1016/s0968-0896(03)00055-5

Cited by 164 publications

(34 citation statements)

References 21 publications

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“…This versatility has made hydrazones good polydentate chelating agents that can form a variety of complexes with various transition metals. In recent years, a number of hydrazone compounds have been prepared and investigated for their biological properties such as antibacterial, antifungal, 5 anticonvulsant, 6 anti-inflammatory, 7 antimalarial, 8 analgesic, 9 antiplatelets, 10 antituberculosis, 11 and anticancer activities. 12 Hydrazones also act as herbicides, insecticides, nematocides, rodenticides, and plant growth regulators, and are used as plasticizers and stabilizers for polymers, polymerization initiators, antioxidants, etc.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structures, and Antibacterial Activity of a Series of Hydrazone Compounds Derived From 4-Methylbenzohydrazide

Yan¹,

Li²,

Fu³

et al. 2015

J. Chil. Chem. Soc.

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A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with different benzaldehydes, were synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction. Crystals of the compounds are stabilized by intermolecular hydrogen bonds, as well as π···π stacking interactions. Antibacterial activity of the compounds against Staphylococcus aureus, Escherichia coli, and Klebsielle pneumoniae strains was studied. Compounds 1 and 2 have moderate minimum inhibition concentration values on the tested bacteria strains. Compound 3, with the Br-substituent groups, showed the highest activity on the bacterial strains.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structures, and Antibacterial Activity of a Series of Hydrazone Compounds Derived From 4-Methylbenzohydrazide

Yan¹,

Li²,

Fu³

et al. 2015

J. Chil. Chem. Soc.

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“…A range of bioactivities are reported for hydrazide-hydrazone compounds, such as antibacterial, anticonvulsant, antimalarial, analgesic, antiinflammatory, antiplatelets, antifungal, antituberculosis, and anticancer activities [1][2][3][4][5][6]. A variety of semicarbazones, thiosemicarbazones and guanyl hydrazones are found to be key compounds for drug design [7], for metal complexes [8], organocatalysis [9], and are used for the preparation of heterocyclic rings [10].…”

Section: Introductionmentioning

confidence: 99%

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors

et al. 2014

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Phenoxyacetohydrazide Schiff base analogs 1-28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC 50 = 9.20 ± 0.32 µM), 5 (IC 50 = 9.47 ± 0.16 µM), 7 (IC 50 = 14.7 ± 0.19 µM), 8 (IC 50 = 15.4 ± 1.56 µM), 11 (IC 50 = 19.6 ± 0.62 µM), 12 (IC 50 = 30.7 ± 1.49 µM), 15 (IC 50 = 12.0 ± 0.16 µM), 21 (IC 50 = 13.7 ± 0.40 µM) and 22 (IC 50 = 22.0 ± 0.14 µM) showed promising β-glucuronidase inhibition activity, better than the standard (D-saccharic acid-1,4-lactone, IC 50 = 48.4 ± 1.25 µM).

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“…Recently, several compounds of this family have been reported as having anti-inflammatory, antiplatelet, antimicrobial, trypanocidal, antimycobacterial, antitumoral and antiviral properties and also activity against several neglected diseases. Therefore, many recent studies have focused on triazoles compounds as target structures and evaluated them in several new biological targets [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…Working with the Information Sciences whatever application area includes a highly structured network since the processes involved in R,D and I drugs are increasingly complex due Big data, it is necessary multidisciplinary teams to establish a systemic vision. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

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confidence: 99%

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Research on Pharmaceuticals Patents in Times of Big Data: A Contribution of the Web 2.0 for Medicinal Chemistry

Magalhães¹,

Quoniam²,

Ferreira³

et al. 2013

Intel Prop Rights

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This work aims to demonstrate the use of tools of Information Science applied to pharmaceutical patents. Given that existence of big data in the new century providing a massive and growing wave of information, it becomes necessary for new ways to rescue data and analyze them consistently. In the public health area is no different, especially with regard to intellectual property for new potential molecules to treat diseases of the global population. The triazoles were used as a study case due the great interest these compounds arouse in the pharmaceutical industry due their biological activities. In this regards, the approach are by consulting databases indexed (PubMed, Web of Science, Medline, Scopus, SciFinder Scholar), beyond to use search engines for data mining and software's from collaborative intelligence to generate graphical analysis. The results demonstrate the potential of four series of triazoles derivatives and illustrate several correlations between patent and pharmaceutical industry extracted from the deep web.

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Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives

Cited by 164 publications

References 21 publications

Synthesis, Crystal Structures, and Antibacterial Activity of a Series of Hydrazone Compounds Derived From 4-Methylbenzohydrazide

Synthesis, Crystal Structures, and Antibacterial Activity of a Series of Hydrazone Compounds Derived From 4-Methylbenzohydrazide

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors

Research on Pharmaceuticals Patents in Times of Big Data: A Contribution of the Web 2.0 for Medicinal Chemistry

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